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Comorbidity of Smoking with Psychiatric Disorders

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Co-occurring Addictive and Psychiatric Disorders

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Abstract

Indications for comorbidity of smoking with psychiatric disorders have been derived from numerous epidemiological studies. This suggests either an involvement of smoking in the development of psychiatric diseases or the importance of smoking as a habit and the neurobiological effects of nicotine in the context of coping strategies for the psychiatric disorders. Neurobiological and genetic research focuses on the cerebral transmitter function including the serotonergic, dopaminergic, and noradrenergic system and cholinergic transmission. Moreover, effects of smoking on medication might motivate medicated psychiatric patients to practice smoking as a form of self-medication.

This chapter will also discuss the need for an intense psychotherapy and when necessary pharmacotherapeutic support in smokers with a psychiatric comorbidity.

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References

  • Ajdacic-Gross V, Landolt K, Angst J, Gamma A, Merikangas KR, Gutzwiller F, Rössler W (2009) Adult versus adolescent onset of smoking: how are mood disorders and other risk factors involved? Addiction 104:1411–1419

    Article  PubMed Central  PubMed  Google Scholar 

  • Allan LM, Williams JH, Wellman NA, Tonin J, Taylor E, Rawlins JNP (1995) Effects of tobacco smoking, schizotypy and number of pre-exposures on latent inhibition in healthy subjects. Pers Individual Dif 19:893–902

    Article  Google Scholar 

  • Almeida LEF, Pereira EFR, Alkondon M, Fawcett WP, Randall WR, Albuquerque EX (2000) The opioid antagonist naltrexone inhibits activity and alters expression of alpha7 and alpha4-beta2 nicotinic receptors in hippocampal neurons: implications for smoking cessation programs. Neuropharmacology 39:2740–2755

    Article  CAS  PubMed  Google Scholar 

  • Batra A (2000) Tobacco use and smoking cessation in the psychiatric patient. Fortschr Neurol Psychiatr 68:80–92

    Article  CAS  PubMed  Google Scholar 

  • Batra A (2005) Genetics of nicotine and tobacco dependency. J Men Health Gender 2(1):100–105

    Article  Google Scholar 

  • Batra A, Buchkremer G (2001) Beziehungen von Alkoholismus, Drogen- und Tabakkonsum. Dt Ärztebl 98:A2590–2593

    Google Scholar 

  • Batra A, Collins SE, Torchalla I, Schröter M, Buchkremer G (2008) Multidimensional smoker profiles and their prediction of smoking following a pharmacobehavioral intervention. J Subst Abuse Treat 35:41–52

    Article  PubMed  Google Scholar 

  • Batra A, Collins SE, Schröter M, Eck S, Torchalla I, Buchkremer G (2010) A cluster-randomised trial of smoking cessation tailored to multidimensional smoker profiles. JSAT 38:128–140

    Google Scholar 

  • Batra A, Niethammer S, Mänz C, Peukert P (2011) Tabakentwöhnung bei stationären Patienten mit einer Alkoholabhängigkeit—Motivationsfaktoren und Erfolgs–aussichten. SUCHT 57(5):337–346

    Article  Google Scholar 

  • Bauer P, Collins S, Batra A (2007) Genotypes in smokers: correlations with smoking behavior. Biochemica 2007(3):10–12

    Google Scholar 

  • Berlin I, Spreux-Varoquaux O, Said S, Launay JM (1997) Effects of past history of major depression on smoking characteristics, monoamine oxidase-A and -B activities and withdrawal symptoms in dependent smokers. Drug Alc Depend 45:31–37

    Article  CAS  Google Scholar 

  • Berlin I, Spreux-Varoquaux O, Launay JM (2000) Platelet monoamine oxidase VB activity is inversely associated with plasma cotinine concentration. Nicotine Tob Res 2:243–246

    Article  CAS  PubMed  Google Scholar 

  • Bobes J, Arango C, Garcia-Garcia M, Rejas J (2010) Healthy lifestyle habits and 10-year cardiovascular risk in schizophrenia spectrum disorders: an analysis of the impact of smoking tobacco in the CLAMORS schizophrenia cohort. Schizophr Res 119:101–109

    Article  PubMed  Google Scholar 

  • Boden JM, Fergusson DM, Horwood LJ (2010) Cigarette smoking and depression: tests of causal linkages using a longitudinal birth cohort. Br J Psychiatry 196:440–446

    Article  PubMed  Google Scholar 

  • Bonevski B, Regan T, Paul C, Baker AL, Bisquera A (2014) Associations between alcohol, smoking, socioeconomic status and comorbidities: evidence from the 45 and Up Study. Drug Alcohol Rev 33(2):169–76. doi:10.1111/dar.12104

    Article  PubMed  Google Scholar 

  • Breslau N, Kilbey MM, Andreski P (1993) Nicotine dependence and major depression. New evidence from a prospective investigation. Arch Gen Psychiatry 50:31–35

    Article  CAS  PubMed  Google Scholar 

  • Brody CL, Hamer DH, Haaga DA (2005) Depression vulnerability, cigarette smoking, and the serotonin transporter gene. Addict Behav 30:557–566

    Article  PubMed  Google Scholar 

  • Chen LS, Xian H, Grucza RA, Saccone NL, Wang JC, Johnson EO, Breslau N, Hatuskami D, Bierut LJ (2012) Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes. Drug Alcohol Depend 123(Suppl 1):S42–51

    Article  CAS  PubMed  Google Scholar 

  • Cole J, Stevenson E, Walker R, Logan TK (2012) Tobacco use and psychiatric comorbidity among adolescents in substance abuse treatment. J Subst Abuse Treat 43(1):20–9

    Article  PubMed  Google Scholar 

  • Colton CW, Manderscheid RW (2006) Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states. Prev Chronic Dis 3:A42

    PubMed Central  PubMed  Google Scholar 

  • Cooper J, Mancuso SG, Borland R, Slade T, Galletly C, Castle D (2012) Tobacco smoking among people living with a psychotic illness: the second Australian Survey of Psychosis. Aust N Z J Psychiatry 46(9):851–63

    Article  PubMed  Google Scholar 

  • Cormac I, Brown A, Creasey S, Ferriter M, Huckstep B (2010) A retrospective evaluation of the impact of total smoking cessation on psychiatric inpatients taking clozapine. Acta Psychiatr Scand 121:393–7

    Article  CAS  PubMed  Google Scholar 

  • deLeon J, Diaz FJ (2012) Genetics of schizophrenia and smoking: an approach to studying their comorbidity based on epidemiological findings. Hum Genet 131(6):877–901

    Article  Google Scholar 

  • Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, MacGregor RR, Alexoff D, Shea C, Wolf AP, Warner D, Zezulkova I, Cilento R (1996) Inhibition of monoamine oxidase in the brains of smokers. Nature 379:733–736

    Article  CAS  PubMed  Google Scholar 

  • Fowler JS, Wang GJ, Volkow ND, Franceschi D, Logan J, Pappas N, Shea C, MacGregor RR, Garza V (1999) Smoking a single cigarette does not produce a measurable reduction in brain MAO B in non smokers. Nicotine Tob Res 1:325–329

    Article  CAS  PubMed  Google Scholar 

  • Gould TJ, Collins AC, Wehner JM (2001) Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition. Nicotine Tob Res 3:17–24

    Article  CAS  PubMed  Google Scholar 

  • Hruska B, Bernier J, Kenner F, Kenne DR, Boros AP, Richardson CJ, Delahanty DL (2014) Examining the relationships between posttraumatic stress disorder symptoms, positive smoking outcome expectancies, and cigarette smoking in people with substance use disorders: a multiple mediator model. Addict Behav 39(1):273–281

    Article  PubMed  Google Scholar 

  • Hughes JR, Helzer JE, Lindberg S (2006) Prevalence of DSM/ICDdefi ned nicotine dependence. Drug Alcohol Depend 85:91–102

    Article  PubMed  Google Scholar 

  • Jähne A, Unbehaun T, Feige B, Lutz U, Batra A, Riemann D (2012) How smoking affects sleep—implications for cessation strategies. Sleep Med 13:1286–1292

    Article  Google Scholar 

  • Jorenby DE, Leischow SJ, Nides MA, Rennard SI, Johnston JA, Hughes AR, Smith SS, Muramoto ML, Daughton DM, Doan K, Fiore MC, Baker TB (1999) A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. N Engl J Med 340:685–689

    Article  CAS  PubMed  Google Scholar 

  • Kumari V, Toone B, Gray JA (1997) Habituation and prepulse inhibition of the acoustic startle reflex: Effects of smoking status and psychosis-proneness. Pers Individual Dif 23:183–191

    Article  Google Scholar 

  • Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH (2000) Smoking and mental illness: a population-based prevalence study. JAMA 284:2606–10

    Article  CAS  PubMed  Google Scholar 

  • Lê Cook B, Wayne GF, Kafali EN, Liu Z, Shu C, Flores M (2014) Trends in smoking among adults with mental illness and association between mental health treatment and smoking cessation. JAMA 311(2):172–182

    Article  Google Scholar 

  • Levin ED, Wilson W, Rose J, McEvoy J (1996) Nicotine-haloperidol interactions and cognitive performance in schizophrenics. Neuropsychopharmacology 15:429–436

    Article  CAS  PubMed  Google Scholar 

  • Lowe EJ, Ackman ML (2010) Impact of tobacco smoking cessation on stable clozapine or olanzapine treatment. Ann Pharmacother 44:727–32

    Article  CAS  PubMed  Google Scholar 

  • Matthies S, Holzner S, Feige B, Scheel C, Perlov E, Ebert D, Tebartz van Elst L, Philipsen A (2013) ADHD as a serious risk factor for early smoking and nicotine dependence in adulthood. J Atten Disord 17(3):176–86

    Article  PubMed  Google Scholar 

  • McEvoy JP, Freudenreich O, Levin ED, Rose JE (1995) Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology 119:124–126

    Article  CAS  PubMed  Google Scholar 

  • Morens DM, Grandinetti A, Reed D, White LR, Ross GW (1995) Cigarette smoking and protection from Parkinson’s disease: false association or etiologic clue? Neurology 45:1041–1051

    Article  CAS  PubMed  Google Scholar 

  • Plassman BL, Helms MJ, Welsh KA, Saunders AM, Breitner JCS (1995) Smoking, Alzheimer’s disease, and confounding with genes. Lancet 345:387

    Article  CAS  PubMed  Google Scholar 

  • Prasad C, Ikegami H, Shimizu I, Onairi ES (1994) Chronic nicotine intake decelerates aging of nigrostriatal dopaminergic neurons. Life Sci 54:1169–1184

    Article  CAS  PubMed  Google Scholar 

  • Romans SE, McNoe BM, Herbison GP, Walton VA, Mullen PE (1993) Cigarette smoking and psychiatric morbidity in women. Aust N Z J Psychiatry 27:399–404

    Article  CAS  PubMed  Google Scholar 

  • Rüther T, Bobes J, De Hert M, Svensson TH, Mann K, Batra A, Gorwood P, Möller HJ (2014) EPA guidance on tobacco dependence and strategies for smoking cessation in people with mental illness. Eur Psychiatry 29(2):65–82

    Article  PubMed  Google Scholar 

  • Sankaranarayanan A, Mancuso S, Castle D (2014) Smoking and suicidality in patients with a psychotic disorder. Psychiatry Res 215(3):634–640

    Article  PubMed  Google Scholar 

  • Smith PH, Homish GG, Giovino GA, Kozlowski LT (2014) Cigarette smoking and mental illness: a study of nicotine withdrawal. Am J Public Health 104(2):e127–e133

    Article  PubMed  Google Scholar 

  • Stage KB, Glassman AH, Covey LS (1996) Depression after smoking cessation: case reports. J Clin Psychiatry 57:467–469

    Article  CAS  PubMed  Google Scholar 

  • Stevens KE, Meltzer J, Rose GM (1995) Nicotinic cholinergic normalization of amphetamine-induced loss of auditory gating in freely moving rats. Psychopharmacology (Berl) 119:163–170

    Article  CAS  Google Scholar 

  • Taylor G, McNeill A, Girling A, Farley A, Lindson-Hawley N, Aveyard P (2014) Change in mental health after smoking scessation: systematic review and meta-analysis. BMJ 348:g1151

    Article  PubMed Central  PubMed  Google Scholar 

  • Thornton JC, Dawe S, Lee C, Capstick C, Corr PJ, Cotter P, Frangou S, Gray NS, Russell MAH, Gray JA (1996) Effects of nicotine and amphetamine on latent inhibition in human subjects. Psychopharmacology (Berl) 127:164–173

    Article  CAS  Google Scholar 

  • Thornton LK, Baker AL, Lewin TJ, Kay-Lambkin FJ, Kavanagh D, Richmond R, Kelly B, Johnson MP (2012) Reasons for substance use among people with mental disorders. Addict Behav 37(4):427–34

    Article  PubMed  Google Scholar 

  • Tsoi DT, Porwal M, Webster AC (2013) Interventions for smoking cessation and reduction in individuals with schizophrenia. Cochrane Database Syst Rev 2, CD007253

    PubMed  Google Scholar 

  • Tsuang MT, Francis T, Minor K, Thomas A, Stone WS (2012) Genetics of smoking and depression. Hum Genet 131(6):905–15

    Article  PubMed  Google Scholar 

  • van der Meer RM, Willemsen MC, Smit F, Cuijpers P (2013) Smoking cessation interventions for smokers with current or past depression. Cochrane Database Syst Rev 8, CD006102

    PubMed  Google Scholar 

  • Wing VC, Wass CE, Soh DW, George TP (2012) A review of neurobiological vulnerability factors and treatment implications for comorbid tobacco dependence in schizophrenia. Ann N Y Acad Sci 1248:89–106

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany

    Anil Batra

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  1. Anil Batra
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Correspondence to Anil Batra .

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Editors and Affiliations

  1. Collaborative Psychiatric Research Institute, Antwerp University PC Alexian Brothers Boechout, Boechout, Belgium

    Geert Dom

  2. Clinical Psychological Service and Department, University Hospital of Psychiatry & University of Bern, Bern, Switzerland

    Franz Moggi

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Batra, A. (2015). Comorbidity of Smoking with Psychiatric Disorders. In: Dom, G., Moggi, F. (eds) Co-occurring Addictive and Psychiatric Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45375-5_20

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  • DOI: https://doi.org/10.1007/978-3-642-45375-5_20

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