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Crystallographic Studies of Proteins Involved in Recombinational Repair and Excision Repair

  • Chapter
DNA Repair

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 12))

Abstract

DNA repair is a very complicated phenomenon that is inseparable from replication and transcription. However, it may be roughly divided into recombinational repair relevant to SOS response and excision repair for the elimination of lesions produced by radiation exposure or by chemical modification. Both of these processes involve various protein factors and enzymes acting on the DNA. These proteins essentially interact with DNA through the recognition of unique conformations around damaged moieties or of four-way junctions at the points of strand exchange. In this respect, they are distinct from other well-characterized DNA binding proteins, such as transcriptional regulatory factors, the functions of which rely upon the specific recognition of base sequences. Thus, a major focus in cell biology and medical sciences is to fully understand the structural basis for the maintenance of genetic information.

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Authors and Affiliations

  1. Biomolecular Engineering Research Institute, 6-2-3 Furuedai, Suita, Osaka 565, Japan

    K. Morikawa

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  1. K. Morikawa
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Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1998 Springer-Verlag Berlin Heidelberg

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Morikawa, K. (1998). Crystallographic Studies of Proteins Involved in Recombinational Repair and Excision Repair. In: Eckstein, F., Lilley, D.M.J. (eds) DNA Repair. Nucleic Acids and Molecular Biology, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48770-5_12

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  • DOI: https://doi.org/10.1007/978-3-642-48770-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48772-9

  • Online ISBN: 978-3-642-48770-5

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