Abstract
Reactivity of lymphocytes in mixed leukocyte culture (MLC) [2, 8] for the most part reflects disparity for the major histocompatibility complex (MHC). The MHC contains loci which control the serologically defined antigens (H-2 of mouse or HL-A of man). However, evidence in the mouse points to the existence of other MHC differences which cannot be detected serologically, but which can lead to MLC activation, and in some cases to graft rejection. This evidence has been extensively reviewed in previous publications [4, 5] and will only be summarized here; the possible relationship of these findings to the detection and definition of tumor antigens will be discussed.
Supported by NIH grants AI 08439 and GM 15422, ONR grant N 00014–67-A-0128–0003, and National Foundation March of Dimes grant CRBS 246.
NIH trainee from NIGMS (Grant No. GM 00398).
MLB is a recipient of the Faculty Research Award of the American Cancer Society.
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References
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Widmer, M.B., Segall, M., Bach, F.H., Bach, M.L. (1974). Lymphocyte-Defined Histocompatibility Differences as a Model for Tumor Antigens. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_11
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DOI: https://doi.org/10.1007/978-3-642-49284-6_11
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