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Granulocyte Colony-Stimulating Factor

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

Granulocyte colony-stimulating factor (G-CSF) is one of the colony-stimulating factors (CSF) which stimulate colony formation from bone marrow cells. Of the four well-known CSFs, G-CSF is the one that specifically regulates proliferation, differentiation, survival, and activation of cells of the restricted neutrophilic granulocyte lineage (Metcalf 1985, 1986, 1987; Sachs 1987). Mouse G-CSF is also called MGI-1G (macrophage and granulocyte inducer type 1, granulocyte) while human G-CSF has been designated pluripotent CSF (pluripoetin) or granulocyte-macrophage colony-stimulating factor β (GM-CSFβ). Recombinant DNA technology has been used to elucidate the molecular and genetic nature of G-CSF (Clark and Kamen 1987) and in vitro and in vivo functions of G-CSF have been extensively studied using recombinant G-CSF. Recent clinical application of G-CSF has shown that this hormone is valuable in the treatment of patients suffering from neutropenia. In this article, current information on G-CSF gene structure and function will be reviewed.

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  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

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Nagata, S. (1990). Granulocyte Colony-Stimulating Factor. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-49295-2_16

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