Abstract
Intraneuronal uptake is responsible for the removal of 1-noradrenaline from the fluid perfusing isolated rabbit hearts (Lindmarand Muscxoll, 1964). In this species, the uptake mechanism is characterized by lacking stereospecificity and by being saturable; however, in spite of the lack of stereospecificity, the rate of uptake of d-noradrenaline is lower than that of the 1-isomer when the heart is perfused with a concentration of the amine (200 ng/ml) that causes partial saturation of uptake (DraskÓczy and Trendelenburg, 1968).
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References
Draskozy, P. R., Trendelenbiirg. U.: The uptake of 1- and d-norepinephrine by the isolated perfused rabbit heart in relation to the stereospecificity of the sensitizing action of cocaine. J. Pharmacol. exp. Ther. 159, 66–73 (1968)
Furchgott, R. F., Sanchez-Garcia, P.: Effects of inhibition of monoamine oxidase on the actions and interactions of norepinephrine, tyramine and other drugs on guinea-pig left atrium. J. Pharmacol. exp. Ther. 163, 98–122 (1968).
Giachetti, A., Shore, P. A.: Optical specificity of monoamine oxidase. Life Sci. 5, 1373–1378 (1966).
Langer, S. Z., TRENDELENBIIRG, U.: The effect of a saturable uptake mechanism on the slopes of dose-response curves for sympathomimetic amines and on the shifts of dose-response curves produced by a competitive antagonist. J. Pharmacol. exp. Ther. 167, 117–142 (1969).
Lindmar, R., MuscaoLL, E.: Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 247, 469–492 (1964).
StjÄrne, L., Euler, U. S. v.: Stereospecificity of amine uptake mechanism in nerve granules. J. Pharmacol. exp. Ther. 150, 335–340, 1965.
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Trendelenburg, U., Draskóczy, P.R., Graefe, KH., Hennemann, H. (1970). Saturation of the Uptake of Noradrenaline as a Determinant of Pharmacological Effects. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49747-6_15
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DOI: https://doi.org/10.1007/978-3-642-49747-6_15
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