Skip to main content
SpringerLink
Log in

Noradrenaline (Arterenol), adrenal medullary hormone and chemical transmitter of adrenergic nerves

  • Chapter
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie

  • 32 Accesses

Abstract

The first intimations of a connection between noradrenaline and the substances assumed to be liberated by sympathetic nerve activity date from the classical workof Barger and Dale, in 1910. On the basis of systematic examinations of the effects of various sympathomimetic amines, the said authors stated: —

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahlquist, R. P.: A study of the adrenotropic receptors. Amer. J. Physiol. 153, 586–600 (1948).

    Google Scholar 

  2. Annersten, Sv., A. GrÖnwall and E. KÖIW: Determination of adrenaline in blood plasma by the fluorescence method. Nature (Lond.) 163, 136–137 (1949).

    Google Scholar 

  3. ÅstrÖm, A.: Anti-sympathetic action of sympathomimetic amines. Acta physiol. scand. (Stockh.) 18, 295–307 (1949).

    Google Scholar 

  4. Auerbach, M. E., and E. Angell: The determination of arterenol in epinephrine. Science (Lancaster, Pa,) 109, 537–538 (1949).

    Google Scholar 

  5. Babsky, E. B.: Sur la formation de substance physiologiquement actives dans les fibres nerveux. Bull. biol. med. Exper. URSS. 5, 51–54 (1938).

    Google Scholar 

  6. Bacq, Z. M.: Recherehes sur la physiologie du systéme nerveux autonome. III. Les proprietés biologiques et physico-chimiques de la sympathine comparees a celles de l’adrénaline. Arch. internat. Physiol. 36, 167–246 (1933).

    Google Scholar 

  7. -La pharmacologie du systéme nerveux autonome, et particulierement du sympatique, d’apres la theorie neurohumorale. Ann. de Physiol.10, 467–553 (1934).

    Google Scholar 

  8. -Artérénol ou adrenaline dans les extraits de tissus. C. r. Soc. Biol. Paris 141, 963–964 (1947).

    Google Scholar 

  9. -Métabolisme et synthése de l’adrènaline. Bull. Acad. Suisse Sei. Med. 4, 127–140 (1948a).

    Google Scholar 

  10. -Facts and theories about sympathins. Science (Lancaster, Pa.) 108, 135 (1948b).

    Google Scholar 

  11. -and P. Fischer: Nature de la substance sympathicomimétique extraite des nerfs ou des tissus des mammifères. Arch. internat. Physiol. 55, 73 (1947).

    Google Scholar 

  12. -, and H. Frédéricq: Sur la nature de l’innervation de la rate. Actions de divers agents pharmacodynamiques. Arch. internat. Physiol. 41, 322–333 (1935).

    Google Scholar 

  13. BARCROFT, H., and H. KONZETT: Action of noradrenaline and adrenaline on human heart-rate. Lancet 1949, 147–148.

    Google Scholar 

  14. BARGER, G.: GEORG FIsHER BAKER Lecture 5. New York: McGrow Hill, Co. 1930.

    Google Scholar 

  15. -, and H. H. DALE: Chemical structure and sympathomimetic action of amines. J.ofPhysiol. 41,19–59(1910–1911).

    Google Scholar 

  16. BERGSTRÖM, S., and HANSSON: To be published 1950.

    Google Scholar 

  17. -U. S. V. EULER and U. HAMBERG: Isolation of nor-adrenaline from the adrenal gland. Acta ehern. scand. (Stockh.) 3, 305 (1949).

    Google Scholar 

  18. ---Isolation of noradrenaline from suprarenal medulla. Acta physiol. scand. (Stockh.) 20, 101–108 (1950).

    Google Scholar 

  19. Beyer, K. H., and S. H. SHAPIRO: The excretion of conjugated epinephrine related compounds. Arner. J. Physiol. 144, 321–330 (1945).

    Google Scholar 

  20. Biber Feld, J.: Pharmakologische Eigenschaften eines synthetisch dargestellten Suprarenins und einiger seiner Derivate. Med. Klin. 1906, 1177–1179.

    Google Scholar 

  21. Blaschko, H.: The activity of l(-)-dopa decarboxylase. J. of Physiol. 101,337 bis 349 (1942).

    Google Scholar 

  22. -Substrate specificity of amino-acid decarboxylases. Biochim. et Biophys. Acta 4, 130–137 (1950).

    Google Scholar 

  23. -P.Holton and G.H.S.Stanlev: The decarboxylation of ß 3: 4-dihydroxyphenylserine (Noradrenaline carboxylic acid). Brit. J. Pharmacol. 3, 315–319 (1948).

    Google Scholar 

  24. -D. Richter and H. Schlossmann: Oxidation of adrenaline and other amines. Biochemie. J. 31, 2187–2196 (1937).

    Google Scholar 

  25. Bloor, W. R., and S. S. Bullen: The determination of adrenaline in blood. J. of biol. Chern. 138, 727–739 (1941).

    Google Scholar 

  26. BÜlbring, E.: The methylation of noradrenaline by minced suprarenal tissue. Brit. J. Pharmacol 4, 234–244 (1949).

    Google Scholar 

  27. -, and J. H. Burn: Liberation of noradrenaline from the suprarenal gland. Brit. J. Pharmacol. 4, 202–208 (1949).

    Google Scholar 

  28. Burn, J. H., and D. E. Hutcheon: The action of noradrenaline. Brit. J. Pharmacol. 4, 373–380 (1949).

    Google Scholar 

  29. Calabro, Q.: Riv. Biol. 15, 299 (1933).

    Google Scholar 

  30. Cannon, W. B., and Z. M. Bacq: Studies on the conditions of activity in endocrine organs. XXVI. A hormone produced by sympathetic action on smooth muscle. Amer. J. Physiol. 96, 392–412 (1931).

    Google Scholar 

  31. -, and K. LissÁk: Evidence for adrenaline in adrenergic neurones. Amer. J. Physiol. 125, 765–777 (1939).

    Google Scholar 

  32. -, and A. Rosenblueth: Sympathin E and sympathin I. Amer. J. Physiol. 104, 557–574 (1933).

    Google Scholar 

  33. --Autonomie neuro-effector systems. New York: MacMillan 1937.

    Google Scholar 

  34. -, and J. E. Urldil: Studies on the conditions of activity in endocrine glands. VIII. Some effects on the denervated he art of stimulating the nerves of the liver. Amer. J. Physiol. 58, 353 (1921).

    Google Scholar 

  35. Cerletti, A., and A. Kallenbjo;RGER: Über die Beeinflussung der Hypoxieprobe an; Menschen durch pharmakodynamische Sympathicolyse. Helvet. physiol. Acta 6, 795–806 (1948).

    Google Scholar 

  36. Consden, R, A. H. Gordon and A. J. P. Martin: Qualitative analysis of proteins: a partition chromatographie method using paper. Biochemie. J. 38, 224–232 (1944).

    Google Scholar 

  37. Craig, L. C.: Identification of small amounts of organic compounds by distribution studies. J. biol. Chem. 155, 519–534 (1.944).

    Google Scholar 

  38. DALE, H. H.: Nomenclature of fibres in the autonomie system and their effects. J. of Physiol. 80, 10–11 (1934).

    Google Scholar 

  39. D’SILVA, J. L.: Action of adrenaline-like substances on the serum potassium. J. of Physiol. 108, 218–225 (1949).

    Google Scholar 

  40. Easson, L. H., and E. Stedman: Studies on the relationship between chemicalconstitution and physiological action. Biochemie. J. 27, 1257–1266 (1933).

    Google Scholar 

  41. Engel, A., and U. S. V. Euler: To be published.

    Google Scholar 

  42. Euler, U. S. v.: The presenee of a substanee with sympathin E properties in spleen extracts. Acta physiol. scand. (Stockh.) 11, 168–186 (1946a).

    Google Scholar 

  43. -The presence of a sympathomimetic substanee in extracts of mammalian heart. J. of Physiol. 105, 38–44 (1946b).

    Google Scholar 

  44. -A specific sympathomimetic ergone in adrenergie nerve fibres (sympathin) and its relation to adrenaline and noradrenaline. Acta physiol. scand. (Stockh.) 12, 73–97 (1946c).

    Google Scholar 

  45. -Identification of the sympathomimetic ergone in adrenergic nerves of cattle (sympathin N) with laevo-noradrenaline. Acta physiol. scand. (Stockh.) 16, 63–74 (1948c).

    Google Scholar 

  46. -Preparation, purification and evaluation of noradrenaline and adrenaline in organ extracts. Arch. internat. Pharmaeodynamie 77, 477–485 (1948d).

    Google Scholar 

  47. -Sympathin E and noradrenaline. Seience (Lancaster, Pa.) 107, 422 (1948e).

    Google Scholar 

  48. -Noradrenalin und Histamin als Wirkstoffe vegetativer Nerven. Z. Vitamin-, Hormon-u. Fermentforschg 2, 596–608 (1948/49).

    Google Scholar 

  49. -Histamine as a specifie. eonstituent of certain autonomie nerve fibres. Aeta physiol. scand. (Stoekh.) 19, 85–93 (1949a).

    Google Scholar 

  50. -The distribution of sympathin N and sympathin A in spleen and splenic nerves of cattle. Aeta physiol. scand. (Stockh.) 19, 207–214 (1949b).

    Google Scholar 

  51. -To be published. 1950.

    Google Scholar 

  52. -, and A. ASTRÖM: Liberation of histamine and sympathin by stimulation of isolated splpuic nerves from cattle. Acta physiol. scand. (Stockh.) 16, 97–104 (1948).

    Google Scholar 

  53. and U. Hamberg: Colorimetric determination of noradrenaline and adrenaline. Acta physiol. scand. (Stockh.) 19, 74–84 (1949a).

    Google Scholar 

  54. --Colorimetric estimation of noradrenaline in the prescnce of adrenaline. Science (Lancaster, Pa.) 110, 561 (1949b).

    Google Scholar 

  55. -— l-nor-Adrenaline in the suprarenal medulla. Nature (Lond.) 163, 642–643 (1949c).

    Google Scholar 

  56. --and A. Purkhold: Noradrenaline and adrenaline in the suprarenals of the guinea-pig. Experientia 5, 451 (1949).

    Google Scholar 

  57. -, and S. Hellner: To be published.

    Google Scholar 

  58. -, and B. HÖKFELT: To be publisehd.

    Google Scholar 

  59. -, and G. Liljestrand: Die Wirkung des Adrenalins auf das Minutenvolumen des Herzens beim Menschen. Skand. Arch. Physiol. (Berl. u. Lpzg.) 52, 243–252 (1927).

    Google Scholar 

  60. --Observations on the pulmonary arterial blood pressure in the cat. Acta physiGl. scand. (Stockh.) 12, 301–320 (1946).

    Google Scholar 

  61. -, and R. Luft: Acta Endocrinolog. 3, 323–330 (1949).

    Google Scholar 

  62. -, and C. G. SchmiterlÖw: Sympathomimetic activity in extracts of normal human and bovine blood. Acta physiol. scand. (Stockh.) 13, 1–8 (1947).

    Google Scholar 

  63. Ewins, A. J.: Some colour reactions of adrenaline and allied bases. J. of Physiol. 40, 317–326 (1910).

    Google Scholar 

  64. Farrerons-Co., F.: Sobre el antagonismo regulador histamina-simpatina, — Sobre los efectos antihistaminicos de la simpatina E. Rev. espan. Fisiol. 4, 57–11, 73–78 (1948).

    Google Scholar 

  65. Finkleman, B.: On the nature of inhibition in the intestine. J. of Physiol. 70, 145–157 (1930).

    Google Scholar 

  66. Folkow, B., J. Frost And B. UvnÄS: Action Of Acetylcholine, Adrenaline And Noradrenaline On The coronary blood flow of the dog. Acta physiol. scand. (Stockh.) 1137, 201–205 (1949)

    Google Scholar 

  67. -, and B. UvnÄs: The chemical transmission of vasoconstrictor impulses to the hind limbs and the splanchnic region of the cat.Acta physiol. scand. (Stockh.) 15, 365–388 (1948).

    Google Scholar 

  68. --The chemical transmission of vasoconstrictor impulses to the hind limbs of the dog. Acta physiol. scand. (Stockh.) 17, 191–194 (1949).

    Google Scholar 

  69. Gaddum, J. H., and L. G. Goodwin: Experiments on liver sympathin. J. of Physiol. 105, 357–369 (1947).

    Google Scholar 

  70. -M. A. Khayyal and H. RYDIN: The release of pharmacologically active substances by nerve trunks during electrical stimulation. J. of Physiol. 89, 9–10 (1937).

    Google Scholar 

  71. -, and H.Kwiatkowski: The action of ephedrine. J. of Physiol. 94, 87–100 (1938).

    Google Scholar 

  72. -, and H. SCHILD: A sensitive physical test for adrenaline. J. of Physiol. 80, 9–10 (1934).

    Google Scholar 

  73. -W. S. PEART and M. VOGT: The estimation of adrenaline and allied substances in blood. J. of Physiol. 108, 467–481 (1949).

    Google Scholar 

  74. Garcia De Jalon, P., J. Bayo Bayo and M. Garcia De Jalon: Farmacoterapia actual (1945).

    Google Scholar 

  75. Gaskell, J. F.: Adrenaline in annelids. J. gen. Physiol. 2, 73–85 (1919).

    Google Scholar 

  76. Gley, P.: Action adrenolytique mais non sympatholytique de la corynanthine. Arch. neerl. Physiol. 28, 462–465 (1947).

    Google Scholar 

  77. Goldenberg, M., K. L. Pines, E. F. Baldwin, D. G. Greene and C. E. Roh: The hemodynamic response of man to norepinephrine and epinephrine and its relation to the problem of hypertension. Amer. J. Med. 5, 792–806 (1948).

    Google Scholar 

  78. Goldenberg, M., M. Faber, E. J. Alston and E. C. Chargaff: Evidence for the occurrence of nor-epinephrine in the adrenal medulla. Science (Lancaster, Pa.) 109, 534–535 (1949).

    Google Scholar 

  79. Goodall, Mcch.: The presence of noradrenaline, adrenaline, and an unknown sympathieolytie factor incattle heart. Acta Physiol scand. (Stockh.) 20, 137–151 (1950).

    Google Scholar 

  80. -Dihydroxyphenylalanine and hydroxytyramine in mammalian suprarenals. Acta Chemica Scand. (Stockh.) 1’950b.

    Google Scholar 

  81. -To be published. 1950.

    Google Scholar 

  82. Green, D. E., and D. Richter: Adren’aline and adrenochrome. Biochemie. J. 31, 596–616 (1937).

    Google Scholar 

  83. Greer, C. M., O. J. Pinkston, J. H. Baxter and E. S. Brannon: Nor-epinephrine (-[3,4-dihydroxyphenyl]-ß-hydroxyethylamine) as a possible mediator in the sympathetic division of the autonomic netvous system. J. of Pharmacol. 62, 189–227 (1938).

    Google Scholar 

  84. Harley-Mason, J.:-The structure of adrenochrome and its reduction products. Experentia 4, 307–308 (1948).

    Google Scholar 

  85. Heard, R. D., and H. S. Raper: VI. A study of the oxidation of 3:4-dihydroxyphenyl-N-methylalanine with reference to its possible function as aprecursor of adrenaline. Biochemie. J. 27, 36 (1933).

    Google Scholar 

  86. H’einrich, P., and W. Schuler: Demonstration der kolorimetrischen Bestimmung von Adrenalin und Arterenol nebeneinander. Helvet. chim. Acta 7, C. 36–C. 37 (1949).

    Google Scholar 

  87. Heymans, C., J. J. Bouckaert, U. S. V. Euler and L. Dautrebande: Sinus carotidiens et reflexes vasomoteurs. Arch. internat. Pharmacodynamie 43, 86–110 (1932).

    Google Scholar 

  88. Hillarp, N.-A.: Structure of the synapse and the peripheral innervation apparatus of the autonomie nervous system. Acta Anatomica, Suppl. 4 (1946).

    Google Scholar 

  89. Hoffmann, F., E. J. Hoffmann, S. Middleton and J. Talesnik: The stimulating effect of acetylcholine on the mammalian heart and the liberation ofan epinephrinelike substance by the,isolated heart. Amer. J. Physiol. 144, 189–198 (1945).

    Google Scholar 

  90. Hökfelt, B.: To be published. 1950.

    Google Scholar 

  91. Holton, P.: Noradrenaline in adrenal medullary tumours. Nature (Lond.) 163, 217 (1949).

    Google Scholar 

  92. Holtz, P., and K. Credner: Die enzymatische Entstehung von Oxytyramin im Organismus und die physiologische Bedeutung der Dopadecarboxylase. Arch. exper. Path. u. Pharmakol. 200, 356–388 (1942).

    Google Scholar 

  93. — and G. Kroneberg: Über das sympathicomimetische pressorische Prinzip des Harns („Urosympathin“). Arch. exper. Path. u. Pharmakol. 204, 228–243 (1947).

    Google Scholar 

  94. -R. Heise and K. LÜdtke: Fermentativer Abbau von l-dioxyphenylalanin (Dopa) durch Niere. Arch. exper. Path. u. Pharmakol. 191, 87-118 (1938/39).

    Google Scholar 

  95. -, and H. J. SchÜmann: Arterenol — ein neues Hormon des Nebennierenmarks. Naturwiss. 35, 159 (1948a).

    Google Scholar 

  96. --Über das Vorkommen von Arterenol in den Nebennieren. Naturwiss. 35, 191–192 (1948b).

    Google Scholar 

  97. --Karotissinusentlastung und Nebennieren. Arterenol chemischer Überträgerstoff sympathischer Nervenerregungen und Hormon des Nebennierenmarks. Arch. exper. Path. u. Pharmakol. 206, 49–64 (1949).

    Google Scholar 

  98. Houssay, B. A., and R. Gerschman: Glucogenolisis hepatica por adrenalina y simpa tina en sa pos normales e hipofisoprivos. Rev. Soc. argent. Biol. 23, 72–80 ( 194 7).

    Google Scholar 

  99. James, W. O.: Demonstration and separation of noradrenaline, adrenaline and methyladrenaline. Nature (Lond.) 161, 851–852 (1948).

    Google Scholar 

  100. Kappert, A., G. C. Sutton, A. Reale, K. H. Skoglund and G. Nylin: The clinical response of human beings to I-noradrenaline and its clinical applicability. Acta Cardiologica 5, 121–136 (1950).

    Google Scholar 

  101. Kendall, E.C.: Hormones of the adrenal cortex. Endocrinology 30, 853–860 (1942).

    Google Scholar 

  102. Klopp, C. T.: The reactions of partially denervated smooth muscle to adrenaline and sympathin. Axner. J. Physiol. 130, 475–480 (1940).

    Google Scholar 

  103. Konschegg, TH.: Ursachen der Hypertonie. Wien. klin. Wschr. 1940, 269–273.

    Google Scholar 

  104. Konzett, H., and C. O. Hebb: Vaso-and bronchomotor actions of noradrenaline (arterenol) and of adrenaline in the isolated perfused lungs of the dog. Arch. internat. Pharmacodynamie 73, 210–224 (1949).

    Google Scholar 

  105. Kutschera-Aichbergen, H. v.: Die Überfunktion und die Unterfunktion der Nebennieren. Schweiz. med. Wschr. 1948, 135–140.

    Google Scholar 

  106. Lissák, K.: Effects of extracts of adrenergic fibres on the frog heart. Amer. J. Physiol. 125, 778–785 (1939a).

    Google Scholar 

  107. -Liberation of acetylcholine and adrenaline by stimulating isolated nerves. Amer. J. Physiol. 127, 263–271 (1939b).

    Google Scholar 

  108. Loewi, O.: Über humorale Übertragbarkeit der Herzennervenwirkung. Arch. ges. Physiol. 189, 239–242 (1921).

    Google Scholar 

  109. -Über den Adrenalingehalt des Säugerherzens. Arch. internat. Pharmacodynamie 57, 139–140 (1937).

    Google Scholar 

  110. Luco’, J. V., and F. GONI: Synaptic fatigue and chemical mediators of postganglionic fibers. J. Neurophysiol. 11, 498–500 (1948).

    Google Scholar 

  111. -, and K. Lissak: Chemical mediators in the aqueous humor. Amer. J. Physiol. 124, 271–278 (1938).

    Google Scholar 

  112. Luduena, F. P., E. Ananenko, O. H. Siegmund and LL. C. Miller: Comparative pharmacology of the optical isomers of arterenol. J. of Pharmacol. 95, 155–169 (1949).

    Google Scholar 

  113. Luft, R., B. SjÖgren and O. Cassmer: To be published.

    Google Scholar 

  114. Lund, A.: Simultaneous fluorimetric determination of adrenaline and noradrenaline in blood. Acta Pharmacol. et toxicol. scand. 1950.

    Google Scholar 

  115. Ll’Ndholm, L.: The effect of l-noradrenaline and ergotamine on the oxygen consumption of guinea-pigs. Acta physiol. scand. (Stockh.) 18, 341–354 (1949).

    Google Scholar 

  116. Malmejac J., et G.’ chardon: Mecanisme de dec1enchement et d’entretien de la secretion surrenale d’adrenaline en anoxie. C. r. Soc. Biol. Paris 141, 395–396 (1947).

    Google Scholar 

  117. Marrazzi, A. S., and R. N. Marrazzi: Chemical structure and the definition of sympathin E. Science (Lancaster, Pa.) 106, 520–521 (1947).

    Google Scholar 

  118. Marsh, D. F., and E. J. Van Liere: The effect of adrenergic blocking agents on the vasoconstriction produced by acute oxygen lack. J. of Pharmacol. 94, 221–223 (1948).

    Google Scholar 

  119. Meier, R., and H. J. Bein: Der Einfluß der Nebenniere auf die Kreislaufwirkung des Adrenalines. Experientia 4, 358 (1948).

    Google Scholar 

  120. Melville, K. J.: Antisympathomimetic action of dioxane compounds (F 883 and F 933), with special reference to vascular responses to dihydroxyphenyl ethanolamine (arterenol) and nerve stimulation. J. of Pharmacol. 59, 317–327 (1937).

    Google Scholar 

  121. Morton, M. C., and M. L. Tainter: Effects of sympathomimetic amines on pelfused blood vessels. J. of Physiol. 98, 263–282 (1940).

    Google Scholar 

  122. Nasmyth, P. A.: The effect of some sympathomimetic amines on the ascorbic acid content of rats’ adrenal glands. J. of Physiol. 110, 294–300 (1949).

    Google Scholar 

  123. Nisell, O.: Acta Physiol scand. (Stockh.) Suppl. 73 (1950).

    Google Scholar 

  124. Norlander, O.: To be published.

    Google Scholar 

  125. ÖStlund, E.: To be published 1950.

    Google Scholar 

  126. Page, I. H.: Personal communication.

    Google Scholar 

  127. Peart, W. S.: The nature of splenic sympathin. J. of Physiol. 108, 491–501 (1949).

    Google Scholar 

  128. Pekkarinen, A.: unpu blished. 1949.

    Google Scholar 

  129. Po Rat, B. V., and U. S. v. Euler: unpublished.

    Google Scholar 

  130. Raab, W.: The pathogenic significance of adrenaline and related substances in the heart musc1e. Exper. med. Surg. 1, 188–225 (1943a).

    Google Scholar 

  131. -Adrenaline and related substances in blood and tissues. Biochemic. J. 37, 470–473 (1943b).

    Google Scholar 

  132. -, and Lepeschkin: Unpublished.

    Google Scholar 

  133. Rein, H., O. Mertens U. F. G. Valdecasas: Gefäßwirkungen des Adrenalins im ruhenden und arbeitenden Muskel. Pflügers Arch. 237, 454–475 (1936).

    Google Scholar 

  134. Rexed, B.: Personal communication.

    Google Scholar 

  135. Richter, D.: The inactivation of adrenaline in vivo in man. J. of Physiol. 98, 361–374 (1940).

    Google Scholar 

  136. -, and F. C. Macintosh: Adrenaline ester. Amer. J. Physiol. 135, 1–5 (1941).

    Google Scholar 

  137. Rosenblueth, A.. and T. Schlossberg: The sensitization of vascular response to “sympathin” by cocaine and the quantitation of “sympathin” in terms of adrenaline. Amer. J, Physiol. 97, 365–374 (1931).

    Google Scholar 

  138. Rydin, H.: The influence of different temperatures on the action of drugs on autonomie effector cells. Acta physiol. scand. (Stockh.) 11, 270–278 (1946).

    Google Scholar 

  139. SchÄfer, H.: To be published 1950.

    Google Scholar 

  140. Scheiner, H.: Action hypertensive des extraits de rate sur le chien atropinise et cocainise. C. r. Soc. Biol. Paris 124, 877–879 (1937a).

    Google Scholar 

  141. -Effets hypertenseurs produits par l’excitation du nerf splenique chez le chien atropinise et cocainise. C. r. Soc. Biol. Paris 124, 1219 (1937b).

    Google Scholar 

  142. Schild, H.: Adrenaline in the suprarenal medulla. J. of Physiol. 79, 455–469 (1933).

    Google Scholar 

  143. SchmiterlÖw, C.: The nature and occurrence of pressor and depressor substances in extracts from blood vessels. Acta physiol. scand. (Stockh.), Suppl. 16, 1–113 (1948).

    Google Scholar 

  144. Schuler, W., and P. Heinrich: Adrenalin und Arterenol im Nebennierenmark verschiedener Tiere. Helv. physiol. pharm. Acta 7, 515–519 (1949).

    Google Scholar 

  145. SchÜ: Publ. Health Marine Hosp. Bull. Washington 1909, No 55.

    Google Scholar 

  146. SchÜ, H. J.: Über die Wirkung von Nebennierenextrakten auf Blutdruck und Blutzucker. Arch.Ltzmann exper. Path. u. Pharmakol. 206, 475–483 (1949).

    Google Scholar 

  147. Shaw, F. H.: The estimation of adrenaline. Biochemie. J. 32, 19–25 (1938).

    Google Scholar 

  148. Stehle, R. L., and H. C. Ellsworth: Dihydroxyphenyl ethanolamine (arterenol) as a possible sympathetic hormone. J. of Pharmacol. 59, 114 (1937).

    Google Scholar 

  149. Stolz, F.: Über Adrenalin und Alkylaminoacetobrenzcatechin. Ber. dtsch. ehern. Ges. 37, 4149–4153 (1904).

    Google Scholar 

  150. Swan, H. J. C.: Effect of noradrenaline on the human circulation. Lancet 257, 508–510 (1949).

    Google Scholar 

  151. Tainter, M. L.: Comparative actions of sympathomimetic compounds: catechol derivatives, and possible mechanism of the sensitization-desensitization phenomena of cocaine. Arch. internat. Pharmacodynamie 41, 365–376 (1931).

    Google Scholar 

  152. -J. R. Pedden and M. James: Comparative actions of sympathomimetic compounds: Bronchodilator actions in perfused guinea pig lungs. J. Pharmacie 51, 371–386 (1934).

    Google Scholar 

  153. -B. F. Tullar and F. P. Luduena: LevoArterenol. Science (Lancaster, Pa.) 107, 39–40 (1948).

    Google Scholar 

  154. Thibault, O.: Adrenaline et sympathine, Action de la nor-Adrenaline sur la consommation d’Oxygene du Rat blanc. C. r. Soc. Biol. Paris 142, 47–50 (1948).

    Google Scholar 

  155. Tullar, B. F.: The resolution of dl-arterenol. J. amer. ehern. Soc. 70, 2067–2068 (1948).

    Google Scholar 

  156. -The separation of l-arterenol from natural U.S.P. epinephrine. Science (Lancaster, Pa.) 109, 536–537 (1949).

    Google Scholar 

  157. Utterback, R. A.: The innervation of the spleen. J. comp. Neur. 81, 55–68 (1944).

    Google Scholar 

  158. Ver LV, W.: La reactif arsenomolybdique perrnet-il de reconnaitre l’adrenaline et l’arterenol dans les extraits tissulaires? Arch. internat. Physiol. 55, 397–408 (1948a).

    Google Scholar 

  159. -Levo-arterenol et arterenol racemique. Arch. internat. Physiol. 55, 409–411 (1948b).

    Google Scholar 

  160. West, G. B.: Quantitative studies of adrenaline and noradrenaline. J. of Physiol. 106, 418–425 (1947).

    Google Scholar 

  161. -Injections of adrenaline and noradrenaline and further studies on liver sympathin. Brit. J. Pharmacol. 3, 189–197 (1948).

    Google Scholar 

  162. -Thevasodepressor action of noradrenaline. Brit. J. Pharrnacol. 4, 63–67 (1949).

    Google Scholar 

  163. Whitehorn, J. C.: A chernical method for estirnating epinephrine in blood, J. of biol. Chern., 633–643 (1935).

    Google Scholar 

Download references

Authors
  1. U. S. v Euler-Stockholm
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Boston, USA

    O. Krayer

  2. Münster i. Westf., Deutschland

    E. Lehnartz

  3. Bern, Deutschland

    A. v. Muralt

  4. Göttingen, Deutschland

    F. H. Rein

Rights and permissions

Reprints and permissions

Copyright information

© 1950 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

v Euler-Stockholm, U.S. (1950). Noradrenaline (Arterenol), adrenal medullary hormone and chemical transmitter of adrenergic nerves. In: Krayer, O., et al. Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49756-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49756-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49472-7

  • Online ISBN: 978-3-642-49756-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation