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Vitamin D-ascorbic Acid Association in Bone Metabolism

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Calcified Tissues 1965
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Abstract

Previous results (Thornton and Brownrigg, 1961) have indicated that ascorbic acid influenced the skeletal response of chicks to vitamin D3 deficiency. Turnover of skeletal 45Ca was enhanced in vitamin D3 deficient individuals in the presence of ascorbic acid, suggesting a change in the bone metabolic rate. No specific role for vitamin D in bone cells has been evolved; however, investigations with cartilage have suggested a metabolic function in that tissue. It appears to be needed for normal formation and metabolism of citric acid (Neuman and Neuman, 1958).

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References

  • Barker, S. B., and W. H. Summerson. The colorimetric determination of lactic acid in biological material. J. biol. Chem. 138, 535 (1941).

    CAS  Google Scholar 

  • Borle, A. B., N. Nichols, and G. Nichols, Jr.. Metabolic studies of bone in vitro. I. Normal bone. J. biol. Chem. 235, 1206 (1960).

    PubMed  CAS  Google Scholar 

  • Cohn, D. V., and B. K. Forscher. Aerobic metabolism of glucose by bone. J. biol. Chem. 237, 615 (1962).

    PubMed  CAS  Google Scholar 

  • Fiske, C. H., and Y. Subbarow. The colorimetric determination of phosphorus. J. biol. Chem. 66, 375 (1925).

    CAS  Google Scholar 

  • Goldhaber, P.: Some factors affecting bone resorption in tissue culture. J. Bone Jt Surg. 43 B, 180 (1961).

    Google Scholar 

  • Gould, B. S., and H. Schwachman. Bone and tissue phosphatase in experimental scurvy and studies on the source of serum phosphatase. Amer. J. Physiol. 135, 485 (1941).

    Google Scholar 

  • Huggett, A. S. C., and D. A. Nixon. Use of glucose oxidase, peroxidase and O-dianisdine in determination of blood and urinary glucose. Lancet, 273, 368 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Levy, B. M., and R. V. GorlinThe temporomandibular joint in vitamin C deficiency. J. dent. Res. 32, 622 (1953).

    Article  PubMed  CAS  Google Scholar 

  • Lilienthal, J. L., Jr.K. L. Zierler, B. P. Folk, R. Buka, and M. J. RileyA reference base and system for analysis of muscle constituents. J. biol. Chem. 182, 501 (1950).

    CAS  Google Scholar 

  • Neuman, W. F., and M. W. Neuman. The Chemical Dynamics of Bone. Chicago: The Uni versity of Chicago Press 1958.

    Google Scholar 

  • Thornton, P. A.: Unpublished.

    Google Scholar 

  • Thornton, P. A., and D. Brownrigg. Calcium utilization and skeletal development in chicks as influenced by parental dietary ascorbic acid. J. Nutr. 75, 354 (1961).

    PubMed  CAS  Google Scholar 

  • Thornton, P. A., C. W. Weber, and R. E. Moreng. The effect of ascorbic acid in the diet of adult chickens on calcium utilization by the progeny. J. Nutr. 69, 33 (1959).

    PubMed  CAS  Google Scholar 

  • Walker, D. G.: Citric acid cycle in osteoblasts and osteoclasts. Bull. Johns Hopk. Hosp. 106, 80 (1961).

    Google Scholar 

  • Willis, J. B.: Determinations of calcium and magnesium in urine by atomic absorption spectroscopy. Analyt. Chem. 33, 556 (1961).

    Article  CAS  Google Scholar 

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© 1966 Springer-Verlag Berlin Heidelberg

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Thornton, P.A. (1966). Vitamin D-ascorbic Acid Association in Bone Metabolism. In: Fleisch, H., Blackwood, H.J.J., Owen, M. (eds) Calcified Tissues 1965. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49802-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-49802-2_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49514-4

  • Online ISBN: 978-3-642-49802-2

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