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Role of Growth Factors in Tumor Growth and Progression of Gynecological Tumors

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Modification of Radiation Response

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The use of biologically-based prognostic factors to determine patient outcome and response to treatment has traditionally used immunohisto chemical techniques for proteins expressed in archival fixed tissue. The increasing use of powerful genomic and proteomic techniques including array technology will increase our understanding of tumor behavior and specific therapeutic targets that maybe exploited to individualize therapy and optimize treatment with radiation and chemotherapy. The development of biologically targeted therapy includes several recent successes including the development of HER2-neu targeting in breast cancer and the bcr-abl/c-kit antagonists in chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors (GIST).

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Alabama at Birmingham, 1824 6th Avenue South, Birmingham, AL, 35294, USA

    J. De Los Santos MD & J. Bonner MD

  2. Department of Radiation Oncology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada

    S. Goddard MD (Research Assistant) & A. Fyles MD

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  1. J. De Los Santos MD
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  2. J. Bonner MD
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  3. S. Goddard MD
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  4. A. Fyles MD
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Editors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße 22, 81675, München, Germany

    Carsten Nieder MD

  2. Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    Luka Milas MD, PhD

  3. Department of Radiation Oncology, UT MD Anderson Cancer Center, 1515 Holcombe Blvd., P.O. Box 66, Houston, TX, 77030, USA

    K. Kian Ang MD, PhD

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De Los Santos, J., Bonner, J., Goddard, S., Fyles, A. (2003). Role of Growth Factors in Tumor Growth and Progression of Gynecological Tumors. In: Nieder, C., Milas, L., Ang, K.K. (eds) Modification of Radiation Response. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55613-5_10

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