Zusammenfassung
Der Ersatz von funktionsuntüchtigem oder zerstörtem Lebergewebe durch funktionsfähiges Parenchym wird Seit nahezu 100 Jahren mit zunehmend aufwendigen und verfeinerten Techniken erforscht. Morphologische Methoden der Anfangszeit wurden in den nachfolgenden Jahrzehnten durch biochemische Verfahren ergänzt. Heute stehen genetische und molekularbiologische Untersuchungen an isolierten und kultivierten menschlichen Hepatozyten im Vordergrund.
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Literatur
Akerman P, Cote P, Yang SQ et al. (1992) Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy. Am J Physiol 263: G579–585
Alison M, Sarraf C (1998) Hepatic stem cells. J Hepatol 29: 676–682
Alison M, Poulsom R, Jeffrey R et al. (2000) Hepatocytes from non-hepatic cells. Nature 406: 257
Alvaro D, Gigliozzi A, Attili AF (2000) Regulation and deregulation of cholangiocyte proliferation. J Hepatol 33: 333–340
Assy N, Minuk GY (1997) Liver regeneration: methods for monitoring and their applications. J Hepatol 26: 945–952
Bottaro DP, Rubin JS, Faletto DL et al. (1991) Identification of the hepatocyte growth factor receptor as the c-met protooncogene product. Science 251: 802–804
Bralet MP, Branchereau S, Brechot C et al. (1994) Cell lineage study in the liver using retroviral mediated gene transfer. Evidence against the streaming of hepatocytes in the normal liver. Am J Pathol 144: 896–905
Bucher NLR, Strain AJ (1992) Regulatory mechanisms in hepatic regeneration. In: Millward-Sadler GH, Wright R, Arthur MIP (eds) Wright’s liver and biliary diseases. Pathophysiology, diagnosis and management, 3rd ed. Saunders, Philadelphia, pp 258–274
Bucher NLR, Farmer S (1998) Liver regeneration after partial hepatectomy: genes and metabolism. In: Strain AJ, Diehl A (eds) Liver growth and repair. Chapman & Hill, London, pp 3–27
Cressman DE, Greenbaum LE, DeAngelis RA et al. (1996) Liver failure and defective regeneration in interleukin-6-deficient mice. Science 274: 1379–1383
Crosby HA, Strain AJ (2001) Adult liver stem cells: bone marrow, blood, or liver derived? Gut 48: 153–154
Date M, Matsuzaki K, Matsushita M et al. (2000) Modulation of transforming growth factor ß function in hepatocytes and hepatic stellate cells in rat liver injury. Gut 46: 719–724
De Vos R, Desmet V (1992) Ultrastructural characteristics of novel epithelial cell types identified in human pathologie liver specimens with chronic ductular reaction. Am J Pathol 140: 1441–1450
Diehl AM (2000) Cytokine regulation of liver injury and repair. Immunol Rev 174: 160–171
Fausto N (2000) Liver regeneration. J Hepatol 32 [suppl 1]: 19–31
Fausto N, Mead JE (1989) Regulation of liver growth: protooncogenes and transforming growth factors. Lab Invest 60: 4–13
Grisham JW (1994) Migration of hepatocytes along the hepatic plates and stem cell-fed hepatocytes lineages. Am J Pathol 144:849–854
Higgins GM, Anderson RM (1931) Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12: 186–202
Kim TH, Mars WM, Stolz DB et al. (2000) Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology 30: 75–82
Marti U, Burwen SI, Jones AL (1989) Biological effects of epidermal growth factor, with emphasis on the gastrointestinal tract and liver: an update. Hepatology 9: 126–138
Miyazawa K, Tsubouchi H, Naka D et al. (1989) Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Com 163: 967–973
Michalopoulos GK (1990) Liver regeneration: molecular mechanisms of growth control. FASEB J 4: 176–187
Nagaki M, Sugiyama A, Naiki T et al. (2000) Control of cyclins, cyclin-dependent kinase inhibitors, p21 and p27, and cell cycle progression in rat hepatocytes by extracellular matrix. J Hepatol 32: 488–496
Nakamura T, Nishizawa T, Hagiya M et al. (1989) Molecular cloning and expression of human hepatocyte growth factor. Nature 342: 440–443
Peters M, Blinn G, Jostock T et al. (2000) Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Gastroenterology 119: 1663–1671
Petersen BE, Bowen WC, Patrene KD et al. (1999) Bone marrow as a potential source of hepatic oval cells. Science 284: 1168–1170
Roskams T, De Vos R, van Eyken P et al. (1998) Hepatic OV-6 expression in human liver disease and rat experiments: evidence for hepatic progenitor cells in man. J Hepatol 29: 455–463
Rubin EM, Martin AA, Thung SN et al. (1995) Morphometric and immunohistochemical characterization of human liver regeneration. Am J Pathol 147: 397–404
Simpson KI, Lukas NW, Colletti L et al. (1997) Cytokines and the liver. J Hepatol 27: 1120–1132
Starzl TE, Terblanche J (1979) Hepatotrophic substances. Progr Liver Dis 6: 135–151
Strain AJ (1988) Transforming growth factor-ß and inhibition of hepatocellular proliferation. Scand J Gastroenterol 23 [suppl 151]: 37–45
Strain AI, Crosby HA (2000) Hepatic stem cells. Gut 46: 743–745
Streetz KL, Luedde T, Manns MP et al. (2000) Interleukin 6 and liver regeneration. Gut 47: 309–312
Theise ND, Badve S, Saxena R et al. (2000) Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 31: 235–240
Theise ND, Nimmakayalu M, Gardner R et al. (2000) Liver from bone marrow in humans. Hepatology 32: 11–16
Wilson IW, Leduc EH (1958) Role of cholangioles in restoration of the liver of the mouse after dietary injury. J Pathol Bacteriol 76: 441–449
Zajjcek G, Oren J, Weinreb M (1985) The streaming liver. Liver 5:295–300
Zhang BH (1997) Growth signals in liver regeneration. J Gastroenterol Hepatol 12: 44–46
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Dancygier, H. (2003). Leberregeneration. In: Klinische Hepatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55902-0_5
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DOI: https://doi.org/10.1007/978-3-642-55902-0_5
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