Skip to main content

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 287 Accesses

Abstract

The therapeutic effect of heat on tumors was recognized more than a century ago, when it was noted that attacks of high fever, as in erysipelas, could reduce the size of malignant tumors. Today, heat in three temperature ranges is used to treat choroidal melanomas. These three temperature ranges (hyperthermia, meaning a tumor temperature of 42–44°C; thermotherapy, with a tumor temperature of 45–65°; and photocoagulation and diathermy, requiring a tumor temperature of over 65°C) are discussed separately.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bartlema YM, Oosterhuis JA, Journée-de Korver HG, TjhoHeslinga RE, Keunen JEE (2001) Treatment of choroidal melanoma with brachytherapy and transpupillary thermotherapy: 5 year follow-up. (submitted for publication)

    Google Scholar 

  • Braakman R, van der Valk JL, van Delft JL et al (1989) The effects of ultrasonically induced hyperthermia on experimental tumors in the rabbit eye. Invest Ophthalmol Vis Sci 30:835–844

    PubMed  CAS  Google Scholar 

  • Coleman DJ, Silverman RH, Ursea R et al (1997) Ultrasonically induced hyperthermia for adjunctive treatment of intraocular malignant melanoma. Retina 17:109–117

    Article  PubMed  CAS  Google Scholar 

  • Collaborative Ocular Melanoma Study Group (1998) Histopathologic characteristics of uveal melanomas in eyes enucleated, from the collaborative ocular melanoma study. (COMS report no 6) Am J Ophthalmol 125:745–766

    Article  Google Scholar 

  • Davidorf FH, Gordon H, Newman GH et al (1970) Conservative management of malignant melanoma. Arch Ophthalmol 83:273–280

    Article  PubMed  CAS  Google Scholar 

  • Diaz CE, Capone A, Grossniklaus HE (1998) Clinicopathologic findings in recurrent choroidal melanoma after transpupillary thermotherapy. Ophthalmology 105:1419–1424

    Article  PubMed  CAS  Google Scholar 

  • Eide N (1999) Primary laser photocoagulation of “small” choroidal melanomas. Acta Ophthalmol Scand 77:351–354

    Article  PubMed  CAS  Google Scholar 

  • Finger PT (1997) Microwave thermoradiotherapy for uveal melanoma, results of a 10 year study. Ophthalmology 104: 1794–1803

    PubMed  CAS  Google Scholar 

  • Garcia-Arumi J (2000) Transpupillary thermotherapy for circumscribed choroidal hemangiomas. Ophthalmology 107:351–357

    Article  PubMed  CAS  Google Scholar 

  • Godfrey DG, Waldron RG, Capone A (1999) Transpupillary thermotherapy for small choroidal melanoma. Am J Ophthalmol 128:88–93

    Article  PubMed  CAS  Google Scholar 

  • Gragoudas ES (1997) Long term results after proton irradiation of uveal melanomas. Graefes Arch Clin Exp Ophthalmol 235:265–267

    Article  PubMed  CAS  Google Scholar 

  • Gündüz K, Shields CL, Shields JA et al (1999) Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol 117:609–614

    Article  PubMed  Google Scholar 

  • Journée-de Korver JG, Oosterhuis JA, Kakebeeke-Kemme HM et al (1992) Transpupillary thermotherapy (TTT) by infrared irradiation of choroidal melanoma. Doc Ophthalmol 82:185–191

    Article  Google Scholar 

  • Journée-de Korver JG, Oosterhuis JA, Vrensen GFJM (1995) Light and electron microscopic findings on experimental melanomas after hyperthermia at 50°C. Melanoma Res 5:393–402

    Article  Google Scholar 

  • Journée-de Korver JG, Oosterhuis JA, de Wolff-Rouendaal D et al (1997) Histopathological findings in human choroidal melanomas after transpupillary thermotherapy. Br J Ophthalmol 81:234–239

    Article  Google Scholar 

  • Kakebeeke-Kemme HM, Oosterhuis JA, de Wolff-Rouendaal D (1985) Five year follow-up study of choroidal and ciliary body melanomas after enucleation. In: Oosterhuis JA (ed) Ophthalmic tumours, 1st edn. Junk, Dordrecht, pp 9–26

    Chapter  Google Scholar 

  • Karlsson UL, Augsburger JJ et al (1990) Recurrence of posterior uveal melanoma after 60CO episcleral plaque therapy. Ophthalmology 96:382–388

    Google Scholar 

  • Keunen JEE, Bleeker JC, Journée de Korver JG et al (1997) Juxtapapillary melanomas and transpupillary thermotherapy. Invest Ophthalmol Vis Sci 38 [Suppl]:S720

    Google Scholar 

  • Keunen JEE, Journée-de Korver JG, Oosterhuis JA (1999) Transpupillary thermotherapy of choroidal melanoma with or without brachytherapy: a dilemma. Br J Ophthalmol 83:1212–1213

    Article  PubMed  CAS  Google Scholar 

  • Laey JJ de, Hanssens M, Ryckaert S (1986) Photocoagulation of malignant melanomas of the choroid, a reappraisal. Bull Soc Beige Ophthalmol 213:9–18

    Google Scholar 

  • Melchers MJ (1953) Diathermy treatment of intraocular tumours. Thesis, University of Utrecht

    Google Scholar 

  • Murray TG, O’Brien JM, Steeves RA et al (1996) Radiation therapy and ferromagnetic hyperthermia in the treatment of murine transgenic retinoblastoma. Arch Ophthalmol 114:1376–1381

    Article  PubMed  CAS  Google Scholar 

  • Murray TG, Steeves RA, Gentry G et al (1997) Ferromagnetic hyperthermia: functional and histopathologic effects on normal rabbit ocular tissue. Int J Hyperthermia 13:423–436

    Article  PubMed  CAS  Google Scholar 

  • Oosterhuis JA, Journée-de Korver HG, Kakebeeke-Kemme HM, Bleeker JC (1995) Transpupillary thermotherapy in choroidal melanomas. Arch Ophthalmol 113:315–321

    Article  PubMed  CAS  Google Scholar 

  • Oosterhuis JA, Journée-de Korver HG, Keunen JJE (1998) Transpupillary thermotherapy. Results in 50 patients with choroidal melanoma. Arch Ophthalmol 116:157–162

    PubMed  CAS  Google Scholar 

  • Othmane IS, Shields CL, Shields JA et al (1999) Circumscribed choroidal hemangioma managed by transpupillary thermotherapy. Arch Ophthalmol 117:136–137

    Article  PubMed  CAS  Google Scholar 

  • Petrovich Z, Pike M, Astrahan MA et al (1996) Episcleral plaque thermoradiotherapy of posterior uveal melanomas. Am J Clin Oncol 19:207–221

    Article  PubMed  CAS  Google Scholar 

  • Rapizzi E, Grizzard S, Capone A (1999) Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma. Am J Ophthalmol 127:481–482

    Article  PubMed  CAS  Google Scholar 

  • Rem AI, Journée-de Korver JG, Oosterhuis JA, et al (1998) Feasibility of Nd:YAG (1064 nm) for transscleral thermotherapy of intraocular tumors. Invest Ophthalmol Vis Sci 39:289

    Google Scholar 

  • Robertson DM, Buettner H, Bennett SR (1999) Transpupillary thermotherapy as primary treatment for small choroidal melanomas. Arch Ophthalmol 117:1512–1519

    Article  PubMed  CAS  Google Scholar 

  • Schneider H, Fischer K, Fietkau R et al (1999) Transpupilläre Thermotherapie des malignen Aderhautmelanoms. Klin Monatsbl Augenheilkd 214:90–95

    Article  PubMed  CAS  Google Scholar 

  • Seregard S, Landau I (2001) Transpupillary thermotherapy as an adjunct to ruthenium plaque radiotherapy for choroidal melanoma. Acta Ophthalamol Scand 79:19–22

    Article  CAS  Google Scholar 

  • Seregard S, Trampe E, Lax I et al (1997) Results following episcleral ruthenium plaque radiotherapy for posterior uveal melanoma. Acta Ophthalmol Scand 75:11–16

    Article  PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, Cater J et al (1998) Transpupillary thermotherapy for choroidal melanoma. Ophthalmology 105:581–590

    Article  PubMed  CAS  Google Scholar 

  • Shields CL, Santos MCM, Diniz W et al (1999) Thermotherapy for retinoblastoma. Arch Ophthalmol 117:885–893

    Article  PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, Perez N, Singh AD, Cater J (2001) Primary transpupillary thermotherapy for choroidal melanoma in 256 consecutive cases: outcomes and limitations. International Congress on Ocular Oncology, Amsterdam, 17–21 June 2001, p 174 (ISBN 9-0901-4923-6)

    Google Scholar 

  • Shields JA, Glazer LC, Mieler WF et al (1990) Comparison of xenon and argon laser photocoagulation in the treatment of choroidal melanomas. Am J Ophthalmol 1009:647–655

    Google Scholar 

  • Weenink AC, van Best JA, Oosterhuis JA et al (1998) Lens transmission by fluorophotometry after brachytherapy and thermotherapy of choroidal melanoma. Ophthalmic Res 30:402–406

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Oosterhuis, J.A., Keunen, J.E.E., Korver, H.G.JD. (2003). Heat Treatment of Choroidal Melanomas. In: Sagerman, R.H., Alberti, W.E. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55910-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-55910-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63147-4

  • Online ISBN: 978-3-642-55910-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics