Abstract
The therapeutic effect of heat on tumors was recognized more than a century ago, when it was noted that attacks of high fever, as in erysipelas, could reduce the size of malignant tumors. Today, heat in three temperature ranges is used to treat choroidal melanomas. These three temperature ranges (hyperthermia, meaning a tumor temperature of 42–44°C; thermotherapy, with a tumor temperature of 45–65°; and photocoagulation and diathermy, requiring a tumor temperature of over 65°C) are discussed separately.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bartlema YM, Oosterhuis JA, Journée-de Korver HG, TjhoHeslinga RE, Keunen JEE (2001) Treatment of choroidal melanoma with brachytherapy and transpupillary thermotherapy: 5 year follow-up. (submitted for publication)
Braakman R, van der Valk JL, van Delft JL et al (1989) The effects of ultrasonically induced hyperthermia on experimental tumors in the rabbit eye. Invest Ophthalmol Vis Sci 30:835–844
Coleman DJ, Silverman RH, Ursea R et al (1997) Ultrasonically induced hyperthermia for adjunctive treatment of intraocular malignant melanoma. Retina 17:109–117
Collaborative Ocular Melanoma Study Group (1998) Histopathologic characteristics of uveal melanomas in eyes enucleated, from the collaborative ocular melanoma study. (COMS report no 6) Am J Ophthalmol 125:745–766
Davidorf FH, Gordon H, Newman GH et al (1970) Conservative management of malignant melanoma. Arch Ophthalmol 83:273–280
Diaz CE, Capone A, Grossniklaus HE (1998) Clinicopathologic findings in recurrent choroidal melanoma after transpupillary thermotherapy. Ophthalmology 105:1419–1424
Eide N (1999) Primary laser photocoagulation of “small” choroidal melanomas. Acta Ophthalmol Scand 77:351–354
Finger PT (1997) Microwave thermoradiotherapy for uveal melanoma, results of a 10 year study. Ophthalmology 104: 1794–1803
Garcia-Arumi J (2000) Transpupillary thermotherapy for circumscribed choroidal hemangiomas. Ophthalmology 107:351–357
Godfrey DG, Waldron RG, Capone A (1999) Transpupillary thermotherapy for small choroidal melanoma. Am J Ophthalmol 128:88–93
Gragoudas ES (1997) Long term results after proton irradiation of uveal melanomas. Graefes Arch Clin Exp Ophthalmol 235:265–267
Gündüz K, Shields CL, Shields JA et al (1999) Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol 117:609–614
Journée-de Korver JG, Oosterhuis JA, Kakebeeke-Kemme HM et al (1992) Transpupillary thermotherapy (TTT) by infrared irradiation of choroidal melanoma. Doc Ophthalmol 82:185–191
Journée-de Korver JG, Oosterhuis JA, Vrensen GFJM (1995) Light and electron microscopic findings on experimental melanomas after hyperthermia at 50°C. Melanoma Res 5:393–402
Journée-de Korver JG, Oosterhuis JA, de Wolff-Rouendaal D et al (1997) Histopathological findings in human choroidal melanomas after transpupillary thermotherapy. Br J Ophthalmol 81:234–239
Kakebeeke-Kemme HM, Oosterhuis JA, de Wolff-Rouendaal D (1985) Five year follow-up study of choroidal and ciliary body melanomas after enucleation. In: Oosterhuis JA (ed) Ophthalmic tumours, 1st edn. Junk, Dordrecht, pp 9–26
Karlsson UL, Augsburger JJ et al (1990) Recurrence of posterior uveal melanoma after 60CO episcleral plaque therapy. Ophthalmology 96:382–388
Keunen JEE, Bleeker JC, Journée de Korver JG et al (1997) Juxtapapillary melanomas and transpupillary thermotherapy. Invest Ophthalmol Vis Sci 38 [Suppl]:S720
Keunen JEE, Journée-de Korver JG, Oosterhuis JA (1999) Transpupillary thermotherapy of choroidal melanoma with or without brachytherapy: a dilemma. Br J Ophthalmol 83:1212–1213
Laey JJ de, Hanssens M, Ryckaert S (1986) Photocoagulation of malignant melanomas of the choroid, a reappraisal. Bull Soc Beige Ophthalmol 213:9–18
Melchers MJ (1953) Diathermy treatment of intraocular tumours. Thesis, University of Utrecht
Murray TG, O’Brien JM, Steeves RA et al (1996) Radiation therapy and ferromagnetic hyperthermia in the treatment of murine transgenic retinoblastoma. Arch Ophthalmol 114:1376–1381
Murray TG, Steeves RA, Gentry G et al (1997) Ferromagnetic hyperthermia: functional and histopathologic effects on normal rabbit ocular tissue. Int J Hyperthermia 13:423–436
Oosterhuis JA, Journée-de Korver HG, Kakebeeke-Kemme HM, Bleeker JC (1995) Transpupillary thermotherapy in choroidal melanomas. Arch Ophthalmol 113:315–321
Oosterhuis JA, Journée-de Korver HG, Keunen JJE (1998) Transpupillary thermotherapy. Results in 50 patients with choroidal melanoma. Arch Ophthalmol 116:157–162
Othmane IS, Shields CL, Shields JA et al (1999) Circumscribed choroidal hemangioma managed by transpupillary thermotherapy. Arch Ophthalmol 117:136–137
Petrovich Z, Pike M, Astrahan MA et al (1996) Episcleral plaque thermoradiotherapy of posterior uveal melanomas. Am J Clin Oncol 19:207–221
Rapizzi E, Grizzard S, Capone A (1999) Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma. Am J Ophthalmol 127:481–482
Rem AI, Journée-de Korver JG, Oosterhuis JA, et al (1998) Feasibility of Nd:YAG (1064 nm) for transscleral thermotherapy of intraocular tumors. Invest Ophthalmol Vis Sci 39:289
Robertson DM, Buettner H, Bennett SR (1999) Transpupillary thermotherapy as primary treatment for small choroidal melanomas. Arch Ophthalmol 117:1512–1519
Schneider H, Fischer K, Fietkau R et al (1999) Transpupilläre Thermotherapie des malignen Aderhautmelanoms. Klin Monatsbl Augenheilkd 214:90–95
Seregard S, Landau I (2001) Transpupillary thermotherapy as an adjunct to ruthenium plaque radiotherapy for choroidal melanoma. Acta Ophthalamol Scand 79:19–22
Seregard S, Trampe E, Lax I et al (1997) Results following episcleral ruthenium plaque radiotherapy for posterior uveal melanoma. Acta Ophthalmol Scand 75:11–16
Shields CL, Shields JA, Cater J et al (1998) Transpupillary thermotherapy for choroidal melanoma. Ophthalmology 105:581–590
Shields CL, Santos MCM, Diniz W et al (1999) Thermotherapy for retinoblastoma. Arch Ophthalmol 117:885–893
Shields CL, Shields JA, Perez N, Singh AD, Cater J (2001) Primary transpupillary thermotherapy for choroidal melanoma in 256 consecutive cases: outcomes and limitations. International Congress on Ocular Oncology, Amsterdam, 17–21 June 2001, p 174 (ISBN 9-0901-4923-6)
Shields JA, Glazer LC, Mieler WF et al (1990) Comparison of xenon and argon laser photocoagulation in the treatment of choroidal melanomas. Am J Ophthalmol 1009:647–655
Weenink AC, van Best JA, Oosterhuis JA et al (1998) Lens transmission by fluorophotometry after brachytherapy and thermotherapy of choroidal melanoma. Ophthalmic Res 30:402–406
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Oosterhuis, J.A., Keunen, J.E.E., Korver, H.G.JD. (2003). Heat Treatment of Choroidal Melanomas. In: Sagerman, R.H., Alberti, W.E. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55910-5_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-55910-5_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-63147-4
Online ISBN: 978-3-642-55910-5
eBook Packages: Springer Book Archive