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Radioactive Plaque Therapy with Iodine-125 and Palladium-103

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Radiotherapy of Intraocular and Orbital Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

In 1930, Moore first used brachytherapy to preserve vision for a monocular patient with uveal melanoma (Finger 1997a). He implanted radon seeds directly into the uveal melanoma. Stallard tried this technique, but went on to develop cobalt-60 (60Co) plaque radiotherapy (Finger 1997a). Since that time there have been multiple phase-I clinical trials describing the use of a variety of brachytherapy sources [primarily ruthenium-106 (106Ru), iodine-125 (125I),iridium-192 (192Ir),and palladium-103 (103Pd)] for eye plaques (Finger 1997a).

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References

  • Alberti W, Pothmann B, Tabor P, Muskalla K, Hermann KP, Harder D (1991) Dosimetry and physieal treatment planning for iodine eye plaque therapy. Int J Radiat Oncol Biol Phys 20:1087–1092

    Article  PubMed  CAS  Google Scholar 

  • Amendola BE, Markoe AM, Augsburger JI, Karlsson UL, Giblin M, Shields JA, Brady LW, Woodleigh R (1989) Analysis of treatment results in 36 children with retinoblastoma treated by scleral plaque irradiation. Int J Radiat Oncol Biol Phys 17:63–70

    Article  PubMed  CAS  Google Scholar 

  • Bosworth JL, Packer S, Rotman M, Ho T, Finger PT (1988) Choroidal melanoma: 1-125 plaque therapy. Radiology 169:249–251

    PubMed  CAS  Google Scholar 

  • Chiu-Tsao ST, Anderson LL (1991) Thermoluminescent dosmietry for 103Pd seeds (model 200) in solid water phantom. Med Phys 18:449–452

    Article  PubMed  CAS  Google Scholar 

  • Diener-West M, Earle JD, Fine SL, Hawkins BS, Moy CS, Reynolds SM, Schachat AP, Straatsma BR (2001) The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma. II. Characteristics of patients enrolled and not enrolled. COMS report no 17. Arch Ophthalmol 119:951–965

    PubMed  CAS  Google Scholar 

  • Diener-West M, Earle JD, Fine SL, Hawkins BS, Moy CS, Reynolds SM, Schachat AP, Straatsma BR (2001) The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma. III. Initial mortality findings. COMS report no 18. Arch Ophthalmol 119:969–982

    PubMed  CAS  Google Scholar 

  • Finger PT (1992) Microwave plaque thermoradiotherapy for choroidal melanoma. Br J Ophthalmol 76:358–364

    Article  PubMed  CAS  Google Scholar 

  • Finger PT (1997a) Radiation therapy for choroidal melanoma. Surv Ophthalmol 42:215–232

    Article  PubMed  CAS  Google Scholar 

  • Finger PT (1997b) Microwave thermoradiotherapy for uveal melanoma: results of a 10-year study. Ophthalmology 104:1794–1803

    PubMed  CAS  Google Scholar 

  • Finger PT (2000a) Intraoperative echographie localization of iodine-125 episcleral plaque for brachytherapy of choroidal melanoma. Am J Ophthalmol 130:539–540

    Article  PubMed  CAS  Google Scholar 

  • Finger PT (2000b) Tumour location affects the incidence of cataract and retinopathy after ophthalmic plaque radiation therapy. Br J Ophthalmol 84:1068–1070

    Article  PubMed  CAS  Google Scholar 

  • Finger PT (2001) Plaque radiation therapy for malignant melanoma of the Iris and Ciliary body. Am J Ophthalmol 132:328–335

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Murphree AL (2001) Ophthalmic brachytherapy: treatment of choroidal melanoma and retinoblastoma. In: Peyman M, Meffert SA, Conway MD, Chou F (eds) Vitreoretinal surgical techniques. Dunitz, London, pp 403–418

    Google Scholar 

  • Finger PT, Packer S (1993) Plaque radiotherapy of retinoblastoma. Ophthalmology 100:1277–1278

    PubMed  CAS  Google Scholar 

  • Finger PT, Packer S, Svitra PP, Paglione RW, Chess J, Albert DM (1984) Hyperthermic treatment of intraocular tumors. Arch Ophthalmol 102:1477–1481

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Packer S, Svitra PP, Paglione RW, Anderson LL, Kim JH, Jacobiec FA (1985) Thermoradiotherapy for intraocular tumors. Arch Ophthalmol 103:1574–1578

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Packer S, Paglione RW, Gatz JF, Ho TK, Bosworth JL (1989) Thermoradiotherapy of choroidal melanoma. Clinical experience. Ophthalmology 96:1384–1388

    PubMed  CAS  Google Scholar 

  • Finger PT, Ho TK, Fastenberg DM, Hyman RA, Stroh EM, Packer S, Perry HD (1990) Intraocular radiation blocking. Invest Ophthalmol Vis Sci 31:1724–1730

    PubMed  CAS  Google Scholar 

  • Finger PT, Moshfeghi DM, Ho TK (1991) Palladium 103 ophthalmic plaque radiotherapy. Arch Ophthalmol 109:1610–1613

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Lu D, Buffa A, DeBlasio DS, Bosworth JL (1993) Palladium-103 versus iodine-125 for ophthalmce plaque radiotherapy. Int J Radiat Oncol Biol Phys 27:849–854

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Buffa A, Mishra S, Berson A, Bosworth JL, Vikram B (1994) Palladium 103 plaque radiotherapy for uveal melanoma. Clinical experience. Ophthalmology 101:256–263

    PubMed  CAS  Google Scholar 

  • Finger PT, Romero JM, Rosen RB, Iezzi R, Emery R, Berson A (1998) Three-dimensional ultrasonography of choroidal melanoma: localization of radioactive eye plaques. Arch Ophthalmol 116:305–312

    PubMed  CAS  Google Scholar 

  • Finger PT, Iezzi R, Estevo ML, Szechter A, Rosen RB, Berson A (1999a) Diode-light transillumination for ophthalmic plaque localization around juxtapapillary choroidal melanomas. Int J Radiat Oncol Biol Phys 44:887–890

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Iezzi R, Romero JM, Rosen RB, Szechter A, Hegde H (1999b) Plaque-mounted diode-light transillumination for localization around intraocular tumors. Arch Ophthalmol 117:179–183

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Berson A, Szechter A (1999c) Palladium-103 plaque radiotherapy for choroidal melanoma: results of a 7-year study. Ophthalmology, 106:606–613

    Article  PubMed  CAS  Google Scholar 

  • Fontanesi J, Meyer D, Xu S, Tai D (1993) Treatment of choroidal melanoma with 1–125 plaque. Int J Radiat Oncol Biol Phys 26:619–623

    Article  PubMed  CAS  Google Scholar 

  • Giblin M (1988) Iodine-125 plaque radiation therapy for choroidal melanoma. In: Proceedings of the annual scientific meeting of the Royal Australian College of Ophthalmology

    Google Scholar 

  • Gunduz K, Shields CL, Shields JA, Cater J, Freire JE, Brady LW (1999) Radiation retinopathy following plaque radiotherapy for posterior uveal melanoma. Arch Ophthalmol 117:609–614

    Article  PubMed  CAS  Google Scholar 

  • Harbour JW, Murray TG, Byrne SF, Hughes JR, Gendron EK, Ehlies FJ, Markoe AM (1996) Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. Retina 16:129–134

    Article  PubMed  CAS  Google Scholar 

  • Hernandez JC, Brady LW, Shields CL, Shields JA, DePotter P (1993) Conservative treatment of retinoblastoma. The use of plaque brachytherapy. Am J Clin Oncol 16:397–401

    Article  PubMed  CAS  Google Scholar 

  • Kiratli H, Bilgic S, Atahan IL (1998) Plaque radiotherapy in the management of retinoblastoma. Turk J Pediatr 40:393–397

    PubMed  CAS  Google Scholar 

  • Kreissig I, Rose D, Jost B (1993) Long-term follow-up of iodine-125 brachytherapy for choroidal melanomas, part I. Anatomical results and life expectancy. Eur J Ophthalmol 3:121–126

    PubMed  CAS  Google Scholar 

  • Lagendijk JJ (1982) A microwave heating technique for the hyperthermic treatment of tumours in the eye, especially retinoblastoma. Phys Med Biol 27:1313–1324

    Article  PubMed  CAS  Google Scholar 

  • Laube T, Fluhs D, Kessler C, En Fisica L, Bornfeld N (2000) Determination of surgeon’s absorbed dose in iodine 125 and ruthenium 106 ophthalmic plaque surgery. Ophthalmology, 107:366–368; discussion 368–369

    Article  PubMed  CAS  Google Scholar 

  • Liggett PE, Ma C, Astrahan M, Pince KJ, Green R, McDonnell J, Petrovich Z (1991) Combined localized current field hyperthermia and irradiation for intraocular tumors. Ophthalmology 98:1830–1835; discussion 1836

    PubMed  CAS  Google Scholar 

  • Lommatzsch PK (1970) Employment of beta-rays with 106Ru-106Rh applicators in the therapy of retinoblastoma. Klin Monatsbl Augenheilkd 156:662–669

    PubMed  CAS  Google Scholar 

  • Lommatzsch PK (1986) Results after beta-irradiation (106Ru/106Rh) of choroidal melanomas: 20 years’ experience. Br J Ophthalmol 70:844–851

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK, Lommatzsch R (1991) Treatment of juxtapapillary melanomas. Br J Ophthalmol 75:715–717

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK, Werner W (1975) Radiation-induced sarcoma 12 years after high dosage x-ray treatment of a bilateral retinoblastoma. Ophthalmologica 171:109–118

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK, Weise B, Ballin R (1986) Optimization of irradiation time in the treatment of malignant melanoma of the choroid with beta applicators (106Ru/106Rh). Klin Monatsbl Augenheilkd 189:133–140

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK, Werschnik C, Schuster E (2000) Long-term follow-up of Ru-106/Rh-106 brachytherapy for posterior uveal melanoma. Graefes Arch Clin Exp Ophthalmol 238:129–137

    Article  PubMed  CAS  Google Scholar 

  • Luxton G, Astrahan MA, Liggett PE, Neblett DL, Cohen DM, Petrovicn Z (1988) Dosimetric calculations and measurements of gold plaque ophthalmic irradiators using iridium-192 and iodine-125 seeds. Int J Radiat Oncol Biol Phys 15:167–176

    Article  PubMed  CAS  Google Scholar 

  • Mameghan H, Karolis C, Fisher R, Mameghan J, Billson FA, Donaldson EJ, Giblin ME, Hunyor AB (1992) Iodine-125 irradiation of choroidal melanoma: clinical experience from the Prince of Wales and Sydney Eye Hospitals. Aust Radiol 36:249–252

    Article  CAS  Google Scholar 

  • Moshfeghi DM, Moshfeghi AA, Finger PT (2000) Enucleation. Surv Ophthalmol 44:277–301

    Article  PubMed  CAS  Google Scholar 

  • Murphree AL, Villablanca JG, Deegan WF 3rd, Sato JK, Mallogolowkin M, Fisher A, Parker R, Reed E, Gomer CJ (1996) Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthalmol 114:1348–1356

    Article  PubMed  CAS  Google Scholar 

  • Myers CA, Abramson DH (1988) Radiation protection. Choroidal melanoma and iodine-125 plaques. J Ophthalmic Nurs Technol 7:103–107

    PubMed  CAS  Google Scholar 

  • Packer S, Rotman M (1980) Radiotherapy of choroidal melanoma with iodine 125. Int Ophthalmol Clin 20:135–142

    PubMed  CAS  Google Scholar 

  • Packer S, Stoller S, Lesser ML, Mandel FS, Finger PT (1992) Long-term results of iodine 125 irradiation of uveal melanoma. Ophthalmology 99:767–773; discussion 774

    PubMed  CAS  Google Scholar 

  • Reminick LR, Finger PT, Ritch R, Weiss S, Ishikawa H (1998) Ultrasound biomicroscopy in the diagnosis and management of anterior segment tumors. J Am Optom Assoc 69:575–582

    PubMed  CAS  Google Scholar 

  • Robertson DM, Fountain KS, Anderson JA, Posthumus GW (1981) Radioactive iodine-125 as a therapeutic radiation source for management of intraocular tumors. Trans Am Ophthalmol Soc 79:294–306

    PubMed  CAS  Google Scholar 

  • Robertson DM, Earle J, Anderson JA (1983) Preliminary observations regarding the use of iodine-125 in the management of choroidal melanoma. Trans Ophthalmol Soc UK 103:155–160

    PubMed  Google Scholar 

  • Robertson DM, Fuller DG, Anderson RE (1987) A technique for accurate placement of episcleral iodine-125 plaques. Am J Ophthalmol 103:63–65

    PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, DePotter P, Hernandez C, Brady LW (1993) Plaque radiotherapy for retinoblastoma. Int Ophthalmol Clin 33:107–118

    Article  PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, DePotter P, Singh AD, Hernandez C, Brady LW (1995) Treatment of non-resectable malignant iris tumours with custom designed plaque radiotherapy. Br J Ophthalmol 79:306–312

    Article  PubMed  CAS  Google Scholar 

  • Stannard C, Sealy R, Shackleton D, Hill J, Korrubel J (1987) The use of iodine-125 plaques in the treatment of retinoblastoma. Ophthalmic Paediatr Genet 8:89–93

    Article  PubMed  CAS  Google Scholar 

  • Wilson MW, Czechonska G, Finger PT, Rausen A, Hooper ME, Haik BG (2001) Chemotherapy for eye cancer. Surv Ophthalmol 45:416–444

    Article  PubMed  CAS  Google Scholar 

  • Wu A, Krasin F (1990) Film dosimetry analyses on the effect of gold shielding for iodine-125 eye plaque therapy for choroidal melanoma. Med Phys 17:843–846

    Article  PubMed  CAS  Google Scholar 

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© 2003 Springer-Verlag Berlin Heidelberg

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Finger, P.T. (2003). Radioactive Plaque Therapy with Iodine-125 and Palladium-103. In: Sagerman, R.H., Alberti, W.E. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55910-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-55910-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63147-4

  • Online ISBN: 978-3-642-55910-5

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