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Arenaviruses: Genomic RNAs, Transcription, and Replication

  • Chapter
Arenaviruses I

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 262))

Abstract

The arenavirus genome comprises two single-stranded RNA molecules of negative polarity, designated L and S, that contain essentially nonoverlapping sequence information (for extensively referenced reviews see Buchmeier et al. 1980; Lehmann-Grube 1984; Howard 1986; Salvato 1993a; Southern 1996). There is some variability in the lengths of the genomic RNA segments for individual arenaviruses (L approximately 7,200 bases, S approximately 3,400 bases), but the general organization of the L and S genomic RNA species appears to be well conserved across the virus family. An extensive compilation of arenavirus genomic RNA sequence is now available, and this information has been used to derive phylogenetic relationships amongst the known arenaviruses (Bowen et al. 1997; Albarino et al. 1998). Sequence alignments have also facilitated the development of a generalized scheme to amplify arenavirus genomic RNAs by RT-PCR (Lozano et al. 1997) This innovative diagnostic resource, together with a specific RT-PCR assay for LCMV (Park et al. 1997), should have a significant positive impact on the rapid recognition and characterization of new arenavirus infections.

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Authors and Affiliations

  1. Air Force Technical Applications Center, Patrick Air Force Base, FL, 32925, USA

    B. J. Meyer

  2. Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, 92037, USA

    J. C. De La Torre

  3. Department of Microbiology, University of Minnesota, Mayo Mail Code 196, 420 Delaware Street, SE, Minneapolis, MN, 55455, USA

    P. J. Southern

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  1. Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone

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Meyer, B.J., De La Torre, J.C., Southern, P.J. (2002). Arenaviruses: Genomic RNAs, Transcription, and Replication. In: Oldstone, M.B.A. (eds) Arenaviruses I. Current Topics in Microbiology and Immunology, vol 262. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56029-3_6

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