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Prospects for Gene Therapy for Brain Tumors

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Combined Modality Therapy of Central Nervous System Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Gliomas are the most common tumors originating in the brain. Most gliomas are malignant. They are the cause of death in almost all patients who harbor them. Even tumors that are originally relatively benign histologically, usually evolve into more malignant tumors and prove life-threatening. Current treatments for malignant gliomas include surgery,radiotherapy, chemotherapy, and immunotherapy, either singly or in combination. Transient control is possible in many cases, yet recurrence is the rule.Possible reasons for tumor recurrence include failure to extirpate all infiltrating tumor cells, tumor resistance to chemotherapy and radiotherapy, and decreased immune response in the brain.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Stanford University, School of Medicine, 300 Pasteur Drive, Boswell Building, A301, Stanford, CA, 94305-5327, USA

    Victor C.-K. Tse MD,MBA

  2. Department of Neurosurgery, Stanford University,School of Medicine, 300 Pasteur Drive,Edwards Building,R227, Stanford, CA, 94305-5327, USA

    Griff Harsh MD,PHD

Authors
  1. Victor C.-K. Tse MD,MBA
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  2. Griff Harsh MD,PHD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Southern California, Keck School of Medicine 1441 Eastlake Avenue, Room G356, Los Angeles, CA, 90033-0804, USA

    Zbigniew Petrovich MD, FACR (Professor and Chairman) (Professor and Chairman)

  2. Department of Radiation Oncology, Hahnemann University Hospital, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102, USA

    Luther W. Brady MD (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor) (Hylda Cohn/ American Cancer Society Professor of Clinical Oncology and Professor)

  3. Keck School of Medicine of the University of Southern California, Los Angeles, CA, 90033, USA

    Michael L. J. Apuzzo MD (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology) (Edwin M. Todd/Trent H. Wells, Jr. Professor of Neurological Surgery and Professor of Radiation Oncology)

  4. Department of Radiotherapy, Eberhard-Karls-Universität, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany

    Michael Bamberg MD

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© 2003 Springer-Verlag Berlin Heidelberg

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Tse, V.CK., Harsh, G. (2003). Prospects for Gene Therapy for Brain Tumors. In: Petrovich, Z., Brady, L.W., Apuzzo, M.L.J., Bamberg, M. (eds) Combined Modality Therapy of Central Nervous System Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56411-6_26

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  • DOI: https://doi.org/10.1007/978-3-642-56411-6_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-00627-5

  • Online ISBN: 978-3-642-56411-6

  • eBook Packages: Springer Book Archive

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