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Einsatz molekularbiologischer Methoden zu Früherkennung und klinischem Management des Zervixkarzinoms

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Gen-Medizin

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Zusammenfassung

Der Gebärmutterhalskrebs ist weltweit gesehen die zweithäufigste Krebserkrankung der Frau (WHO 1990). Er entsteht über seine Präkanzerose, die zervikale intraepitheliale Neoplasie (CIN). Diese verläuft über drei Schweregrade, CIN 1 bis CIN 3, bevor sie mit einer Latenz von 10 Jahren und mehr in das invasive Plattenepithelkarzinom übergehen kann [72]. Die Prävalenz der CIN zeigte in Westeuropa und den USA eine ständige Zunahme in den letzten zwei Dekaden und liegt bei ca. 3–5% [2,10,82]. Es sind vorwiegend Frauen im reproduktiven Alter zwischen 25 und 40 Jahren betroffen. Die Krebsvorsorge in der westlichen Welt — mit zytologischen Kontrollen im Stadium CIN 1 und 2 (Pap IIID) und chirurgischer Therapie im Stadium CIN 3 (Pap IVa) — bewirkte einen deutlichen Rückgang der Zervixkarzinommortalität um ca. 40%. Allerdings stagniert diese Zahl in den westlichen Ländern seit einem Jahrzehnt. Die Leistungsfähigkeit der klassischen Vorsorge scheint an ihre Grenzen angelangt zu sein. Neue Screening- und Diagnosestrategien werden derzeit auf ihre Wertigkeit im klinischen Alltag überprüft.

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  1. P. Hillemanns
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  2. R. Kimmig
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  3. C. J. Thaler
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Editors and Affiliations

  1. Hasenbusch 27, 48159, Münster, Deutschland

    Arnold Maria Raem

  2. Labor Prof. Enders & Partner, Rosenbergstraße 85, 70193, Stuttgart, Deutschland

    Rüdiger W. Braun

  3. Hedwigstraße 12, 48149, Münster, Deutschland

    Hermann Fenger

  4. Universität Augsburg, Universitätsstraße 10, 86159, Augsburg, Deutschland

    Wolfgang Michaelis

  5. Medizinische Klinik I Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, München, Deutschland

    Sigrid Nikol

  6. Bundesärztekammer Dezernat VI (Wissenschaft und Forschung), Herbert-Lewin-Straße 1, 50931, Köln, Deutschland

    Stefan F. Winter

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Hillemanns, P., Kimmig, R., Thaler, C.J. (2001). Einsatz molekularbiologischer Methoden zu Früherkennung und klinischem Management des Zervixkarzinoms. In: Raem, A.M., Braun, R.W., Fenger, H., Michaelis, W., Nikol, S., Winter, S.F. (eds) Gen-Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56818-3_13

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