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The 5-HT3 Receptor Channel: Function, Activation and Regulation

  • Chapter
Pharmacology of Ionic Channel Function: Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 147))

Abstract

The 5-HT3 receptor (5-HT3R) is a ligand-gated ion channel gated by the neurotransmitter serotonin (5-HT) and belonging to the superfamily of ligand-gated ion channels, a group that includes nicotinic acetylcholine (ACh), GABA, and glycine receptor channels (MARiCQ et al. 1991). The activation of the 5-HT3R opens a cationic ion channel that depolarizes the membrane, thereby activating a rapid excitatory response in a variety of central and peripheral nervous system (CNS and PNS) preparations. Thus the 5-HT3R is unique from the other classes of 5-HT receptors which all couple to GTP binding proteins.

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  1. J. L. Yakel
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Editors and Affiliations

  1. Saitama Medical School, 38 Morohongo, Moroyama Iruma-Gun, Saitama, 350-0495, Japan

    Makato Endo M.D., Ph.D.

  2. Department of Pharmacology II Graduate School of Medicine and Faculty of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yoshihisa Kurachi

  3. Department of Molecular Neurobiology and Pharmacology School of Medicine, University of Tokyo, Hongo 7-3-1, Bukyo-ku, Tokyo, 113-0033, Japan

    Masayoshi Mishina

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Yakel, J.L. (2000). The 5-HT3 Receptor Channel: Function, Activation and Regulation. In: Endo, M., Kurachi, Y., Mishina, M. (eds) Pharmacology of Ionic Channel Function: Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 147. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57083-4_21

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