Summary
The destiny of the ischemic penumbra - defined as a territory of critically reduced blood flow in the close neighborhood of an ischemic core - determines outcome from stroke. Currently, the pathophysiology of the penumbra is studied mainly in rat models with occlusion of the middle cerebral artery. Here, we propose another rat model with distinct advantages. It produces a large territory of critical flow reduction in the cortex of one hemisphere without the presence of an infarct core; this model is suited to study mediator mechanisms that may turn the penumbra into necrotic tissue. It is produced by occluding one carotid artery and, in addition, reducing arterial pressure to 50 mmHg using the hypobaric hypotension technique. Cortical flow is assessed by laser Doppler scanning. Induction of cortical spreading depression is used to evaluate whether spreading-depression-induced increases of cortical blood flow are absent as an indicator of penumbra conditions.
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© 1999 Springer-Verlag Berlin Heidelberg
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Seiwert, T., Heimann, A., Kempski, O. (1999). A Rat Model to Study Damage and Defense Mechanisms Under Penumbra Conditions. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_33
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DOI: https://doi.org/10.1007/978-3-642-58602-6_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-65023-2
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