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Optical Insights Into Cerebellar Circuitry

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Neural Circuits and Networks

Part of the book series: NATO ASI Series ((NATO ASI F,volume 167))

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Abstract

It is commonly accepted that a deeper understanding of how neural networks function will depend on the ability to monitor brain activity with high temporal and spatial resolution. The need for such monitoring systems led in the early seventies to the development of optical imaging techniques using voltage-sensitive dyes (Ross et al. 1974). The technique is based on the detection of light emitted from special dye molecules that bind to membranes and fluoresce proportionally to the membrane potential. In its current state the method is particularly suitable for monitoring synchronized activity in large neuron populations as demonstrated here in the cerebellar cortex.

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References

  • Cohen, D., Segev, I., and Yarom, Y. 1997. Optical measurements reveal patchy organization of activity in the cerebellar cortex following mossy fiber stimulation. Soc. Neurosci. Abst. 23 1286.

    Google Scholar 

  • Ebner T. J. and Chen G. 1995. Use of voltage-sensitive dyes and optical recordings in the central nervous system. Progress in Neurobiology 46: 463–506.

    Article  Google Scholar 

  • Eccles, J. C., Ito, M., and Szentagothai, J., 1967. The Cerebellum as a Neuronal Machine (Springer-Verlag Berlin).

    Google Scholar 

  • Grinvald, A., Frostig, R. D., Lieke, E. E., and Hildesheim, R. 1988. Optical imaging of neuronal activity. Physiological Review 1285–1366.

    Google Scholar 

  • Ito M. 1984. The cerebellum and neural control. Raven Press New York.

    Google Scholar 

  • Konnerth, A., Obaid, A. L., and Salzberg, B. M. 1987. Optical recording of electrical activity from parallel fibers and other cell types in skate cerebellar slices. J. Physiol. 393 681–702.

    Google Scholar 

  • Llinas R. 1981. Electrophysiology of the cerebellar networks. In Handbook of Physiology-The Nervous System II. V. B. Brooks ed.

    Google Scholar 

  • Llinas, R., Yarom, Y., and Sugimori, R. 1981. Isolated mammalian brain in-vitro: New technique for analysis of electrical activity of neuronal circuit function. Fed. Proc. 40 2240–2245.

    Google Scholar 

  • Palay, S. L., and Chan-Palay, V. 1974. Cerebellar Cortex (Springer-Verlag New York).

    Google Scholar 

  • Ross, W. N., Salzberg, B. M., Cohen, L. B., and Davila, H. V. 1974. A large change in dye absorption during the action potential. Biophys. J. 14 983–986.

    Article  Google Scholar 

  • Saltzberg B. M. 1989. Optical recording of voltage changes in nerve terminals and in the fine neuronal processes. Physiological Review A. 507–526.

    Google Scholar 

  • Wu J. Y. and Cohen L. B. 1993. Fluorescent and Luminescent Probes for Biological Activity: A Practical Guide to Technology for Quantitative Real-Time Analysis. W. T. Mason ed. (Academic Press London).

    Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Cohen, D., Yarom, Y. (1998). Optical Insights Into Cerebellar Circuitry. In: Torre, V., Nicholls, J. (eds) Neural Circuits and Networks. NATO ASI Series, vol 167. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58955-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-58955-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63801-5

  • Online ISBN: 978-3-642-58955-3

  • eBook Packages: Springer Book Archive

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