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Zellzyklus und Apoptose

  • Chapter
Molekularmedizinische Grundlagen von hämatologischen Neoplasien

Part of the book series: Molekulare Medizin ((MOLMED))

Zusammenfassung

Die Regulation von Zeilproliferation und Zelltod erfolgt durch eng miteinander verknüpfte Signalwege. Im normalen und ausgereiften, adulten, sich aber dennoch ständig selbst erneuernden Gewebe besteht ein dynamisches Gleichgewicht zwischen Zellproliferation durch mitotische Teilung und Zelluntergang durch programmierten Zelltod (Apoptose) (Kerr et al. 1972; Meier et al. 2000; Evan u. Vousden 2001). Beide Phänomene werden durch komplizierte Regulationssysteme engmaschig kontrolliert (Krammer et al. 1994; Daniel 2000). Dies spiegelt sich auch in der Bedeutung dieser beiden zellbiologischen Phänomene bei der Entstehung von benignen (McDonnell et al. 1989) und malignen Tumoren wieder (Tsujimoto et al. 1984; Vaux et al. 1988; Burns et al. 1991; Yonish-Rouach et al. 1991; Soengas et al. 1999).

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Literatur

  • Abraham RT (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177–2196

    PubMed  CAS  Google Scholar 

  • Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281:1322–1326

    PubMed  CAS  Google Scholar 

  • Adams PD, Kaelin WG Jr (1996) The cellular effects of E2F overexpression. Curr Top Microbiol Immunol 208:79–93

    PubMed  CAS  Google Scholar 

  • Adams JM, Huang DC, Puthalakath H et al. (1999) Control of apoptosis in hematopoietic cells by the Bcl-2 family of proteins. Cold Spring Harb Symp Quant Biol 64:351–358

    PubMed  CAS  Google Scholar 

  • Adjei AA (2001) Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 93:1062–1074

    PubMed  CAS  Google Scholar 

  • Alessi DR, Cohen P (1998) Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 8:55–62

    PubMed  CAS  Google Scholar 

  • Alessi DR, James SR, Downes CP et al. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr Biol 7:261–269

    PubMed  CAS  Google Scholar 

  • Almasan A, Linke SP, Paulson TG, Huang LC, Wahl GM (1995) Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metastasis Rev 14:59–73

    PubMed  CAS  Google Scholar 

  • Altieri DC, Marchisio PC, Marchisio C (1999) Survivin apoptosis: an interloper between cell death and cell proliferation in cancer. Lab Invest 79:1327–1333

    PubMed  CAS  Google Scholar 

  • Altura RA, Inukai T, Ashmun RA, Zambetti GP, Roussel MF, Look AT (1998) The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells. Blood 92:1397–13405

    PubMed  CAS  Google Scholar 

  • Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H (1992) Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature 359:423–426

    PubMed  CAS  Google Scholar 

  • Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H (1993a) Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72:233–245

    PubMed  CAS  Google Scholar 

  • Amati B, Littlewood TD, Evan GI, Land H (1993b) The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J 12:5083–5087

    PubMed  CAS  Google Scholar 

  • Bai C, Richman R, Elledge S J (1994) Human cyclin F. EMBO J 13:6087–6098

    PubMed  CAS  Google Scholar 

  • Banner DW, D’Arcy A, Janes W et al. (1993) Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 73:431–445

    PubMed  CAS  Google Scholar 

  • Beaupre DM, Kurzrock R (1999) RAS and leukemia: from basic mechanisms to gene-directed therapy. J Clin Oncol 17:1071–1079

    PubMed  CAS  Google Scholar 

  • Benedict MA, Hu Y, Inohara N, Nunez G (2000) Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9. J Biol Chem 275:8461–8468

    PubMed  CAS  Google Scholar 

  • Bergeron L, Yuan J (1998) Sealing one’s fate: control of cell death in neurons. Curr Opin Neurobiol 8:55–63

    PubMed  CAS  Google Scholar 

  • Boddy MN, Furnari B, Mondesert O, Russell P (1998) Replication checkpoint enforced by kinases Cds1 and Chk1. Science 280:909–912

    PubMed  CAS  Google Scholar 

  • Bordeleau LN, Berinstein L (2000) Molecular diagnostics in follicular non-Hodgkin’s lymphoma: a review. Semin Oncol 27:42–52

    PubMed  CAS  Google Scholar 

  • Bosanquet AG, Sturm I, Wieder T et al. (2002) Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia. Leukemia 16:1035–1044

    PubMed  CAS  Google Scholar 

  • Bouillet P, Metcalf D, Huang DC et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286:1735–1738

    PubMed  CAS  Google Scholar 

  • Britos-Bray M, Ramirez M, Cao W et al. (1998) CBFβeta-SMMHC, expressed in M4eo acute myeloid leukemia, reduces p53 induction and slows apoptosis in hematopoietic cells exposed to DNA-damaging agents. Blood 92:4344–4352

    PubMed  CAS  Google Scholar 

  • Brondello JM, Boddy MN, Furnari B, Russell P (1999) Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases. Mol Cell Biol 19:4262–4269

    PubMed  CAS  Google Scholar 

  • Bunz F, Dutriaux A, Lengauer C et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497–1501

    PubMed  CAS  Google Scholar 

  • Burns PA, Kemp CJ, Gannon JV, Lane DP, Bremner R, Balmain A (1991) Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice. Oncogene 6:2363–2369

    PubMed  CAS  Google Scholar 

  • Burtelow MA, Roos-Mattjus PM, Rauen M, Babendure JR, Karnitz LM (2001) Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9–1–1) DNA damage responsive checkpoint complex. J Biol Chem 276:25903–25909

    PubMed  CAS  Google Scholar 

  • Cartwright P, Muller H, Wagener C, Holm K, Heiin K (1998) E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 17:611–623

    PubMed  CAS  Google Scholar 

  • Caspari T, Carr AM (1999) DNA structure checkpoint pathways in Schizosaccharomyces pombe. Biochimie 81:173–181

    PubMed  CAS  Google Scholar 

  • Catovsky D (1997) The search for genetic clues in chronic lymphocytic leukemia. Hematol Cell Ther [Suppl 1] 39:S5–11

    Google Scholar 

  • Cerutti L, Simanis V (2000) Controlling the end of the cell cycle. Curr Opin Genet Dev 10:65–69

    PubMed  CAS  Google Scholar 

  • Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B (1999) 14–3–3 Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401:616–620

    PubMed  CAS  Google Scholar 

  • Chan TA, Hwang PM, Hermeking H, Kinzler KW, Vogelstein B (2000) Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev 14:1584–1588

    PubMed  CAS  Google Scholar 

  • Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE (2001) Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol Cell 8:1105–1115

    PubMed  CAS  Google Scholar 

  • Cheng EH, Kirsch DG, Clem RJ et al. (1997) Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278:1966–1968

    PubMed  CAS  Google Scholar 

  • Child ES, Mann DJ (2001) Novel properties of the cyclin encoded by human herpesvirus 8 that facilitate exit from quiescence. Oncogene 20:3311–3322

    PubMed  CAS  Google Scholar 

  • Chlichlia K, Moldenhauer G, Daniel PT et al. (1995) Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis. Oncogene 10:269–277

    PubMed  CAS  Google Scholar 

  • Classon M, Dyson N (2001) p107 and p130: versatile proteins with interesting pockets. Exp Cell Res 264:135–147

    PubMed  CAS  Google Scholar 

  • Clem RJ (2001) Baculoviruses and apoptosis: the good, the bad, and the ugly. Cell Death Differ 8:137–143

    PubMed  CAS  Google Scholar 

  • Coleman TR, Dunphy WG (1994) Cdc2 regulatory factors. Curr Opin Cell Biol 6:877–882

    PubMed  CAS  Google Scholar 

  • Coller HA, Grandori C, Tamayo P et al. (2000) Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci USA 97:3260–3265

    PubMed  CAS  Google Scholar 

  • Colussi C, Fiumicino S, Giuliani A et al. (2001) 1,2-dimethyl-hydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice. J Natl Cancer Inst 93:1534–1540

    PubMed  CAS  Google Scholar 

  • Corradini P, Ladetto M, Inghirami G, Boccadoro M, Pileri A (1994) N- and K-ras oncogenes in plasma cell dyscrasias. Leuk Lymphoma 15:17–20

    PubMed  CAS  Google Scholar 

  • Cory S, Vaux DL, Strasser A, Harris AW, Adams JM (1999) Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer Res 59:1685s–1692s

    PubMed  CAS  Google Scholar 

  • Coutre P le, Tassi E, Varella-Garcia M et al. (2000) Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood 95:1758–1766

    PubMed  Google Scholar 

  • Crompton M (2000) Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis. Curr Opin Cell Biol 12:414–419

    PubMed  CAS  Google Scholar 

  • Crul M, Klerk GJ de, Beijnen JH, Schellens JH (2001) Ras biochemistry and farnesyl transferase inhibitors: a literature survey. Anticancer Drugs 12:163–184

    PubMed  CAS  Google Scholar 

  • Daniel PT (2000) Dissecting the pathways to death. Leukemia 14:2035–2044

    PubMed  CAS  Google Scholar 

  • Daniel PT, Sturm I, Ritschel S et al. (1999) Detection of genomic DNA fragmentation during apoptosis (DNA ladder) and the simultaneous isolation of RNA from low cell numbers. Anal Biochem 266:110–115

    PubMed  CAS  Google Scholar 

  • Daniel PT, Sturm I, Wieder T, Schulze-Osthoff K (2001) The kiss of death: promises and failures of death receptors and ligands in cancer therapy. Leukemia 15:1022–1032

    PubMed  CAS  Google Scholar 

  • Daniel PT, Sturm I, Gillissen B (2002) Tumour genotype and response to cytotoxic gene therapy. In: Subramanian G (ed) Manufacturing of gene therapeutics. Kluwer Academic Publisher, Dordrecht, 1:59–98

    Google Scholar 

  • Dbaibo GS, Hannun YA (1998) Cytokine response modifier A (CrmA): a strategically deployed viral weapon. Clin Immunol Immunopathol 86:134–140

    PubMed  CAS  Google Scholar 

  • Desagher S, Osen-Sand A, Nichols A et al. (1999) Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 144:891–901

    PubMed  CAS  Google Scholar 

  • Deveraux QL, Reed JC (1999) IAP family proteins — suppressors of apoptosis. Genes Dev 13:239–252

    PubMed  CAS  Google Scholar 

  • Dierlamm J, Baens M, Wlodarska I et al. (1999) The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 93:3601–3609

    PubMed  CAS  Google Scholar 

  • Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A (1999) The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. J Exp Med 190:1025–1032

    PubMed  CAS  Google Scholar 

  • Donjerkovic DD, Scott W (2000) Regulation of the G1 phase of the mammalian cell cycle. Cell Res 10:1–16

    PubMed  CAS  Google Scholar 

  • Donnellan R, Chetty R (1998) Cyclin D1 and human neoplasia. Mol Pathol 51:1–7

    PubMed  CAS  Google Scholar 

  • Druker BJ, Lydon NB (2000) Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J Clin Invest 105:3–7

    PubMed  CAS  Google Scholar 

  • Du C, Fang M, Li Y, Lix Wang L (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102:33–42

    PubMed  CAS  Google Scholar 

  • Dyer C, Sinclair A (1998) The premature ageing syndromes: insights into the ageing process. Age Ageing 27:73–80

    PubMed  CAS  Google Scholar 

  • Eiben LJ, Duckett CS (1998) The IAP family of apoptotic regulators. Results Probl Cell Differ 24:91–104

    PubMed  CAS  Google Scholar 

  • Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL (1999) Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 13:2658–2669

    PubMed  CAS  Google Scholar 

  • Eischen CM, Roussel MF, Korsmeyer S J, Cleveland JL (2001) Bax loss impairs myc-induced apoptosis and circumvents the selection of p53 mutations during myc-mediated lymphomagenesis. Mol Cell Biol 21:7653–7662

    PubMed  CAS  Google Scholar 

  • Eisenman RN (2001) Deconstructing myc. Genes Dev 15:2023–2030

    PubMed  CAS  Google Scholar 

  • Ekert PG, Silke J, Vaux DL (1999) Caspase inhibitors. Cell Death Differ 6:1081–1086

    PubMed  CAS  Google Scholar 

  • Ekholm SV, Reed SI (2000) Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle. Curr Opin Cell Biol 12:676–684

    PubMed  CAS  Google Scholar 

  • Elledge SJ (1998) Mitotic arrest: Mad2 prevents sleepy from waking up the APC. Science 279:999–1000

    PubMed  CAS  Google Scholar 

  • Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S (1998) A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43–50

    PubMed  CAS  Google Scholar 

  • Epstein CJ, Motulsky AG (1996) Werner syndrome: entering the helicase era. Bioessays 18:1025–1027

    PubMed  CAS  Google Scholar 

  • Erlanson M, Landberg G (2001) Prognostic implications of p27 and cyclin E protein contents in malignant lymphomas. Leuk Lymphoma 40:461–470

    PubMed  CAS  Google Scholar 

  • Evan GI, Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411:342–348

    PubMed  CAS  Google Scholar 

  • Evan GI, Wyllie AH, Gilbert CS et al. (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128

    PubMed  CAS  Google Scholar 

  • Fang G, Kim CN, Perkins CL et al. (2000) CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs. Blood 96:2246–2253

    PubMed  CAS  Google Scholar 

  • Farrow SN, White JH, Martinou I et al. (1995) Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature 374:731–733

    PubMed  CAS  Google Scholar 

  • Foster BA, Coffey HA, Morin MJ, Rastinejad F (1999) Pharmacological rescue of mutant p53 conformation and function. Science 286:2507–2510

    PubMed  CAS  Google Scholar 

  • Frei C, Gasser SM (2000) RecQ-like helicases: the DNA replication checkpoint connection. J Cell Sci 113:2641–2646

    PubMed  CAS  Google Scholar 

  • Friedrich K, Wieder T, Haefen C von et al. (2001) Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance. Oncogene 20:2749–2760

    PubMed  CAS  Google Scholar 

  • Fu H, Subramanian RR, Masters SC (2000) 14–3–3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol 40:617–647

    PubMed  CAS  Google Scholar 

  • Funk JO (1999) Cancer cell cycle control. Anticancer Res 19:4772–4780

    PubMed  CAS  Google Scholar 

  • Gallimore PH, Turnell AS (2001) Adenovirus E1A: remodelling the host cell, a life or death experience. Oncogene 20:7824–7835

    PubMed  CAS  Google Scholar 

  • Gascoyne RD, Adomat SA, Krajewski S et al. (1997) Prognostic significance of Bcl-2 protein expression and bcl-2-gene rearrangement in diffuse aggressive non-Hodgkin’s lymphoma. Blood 90:244–251

    PubMed  CAS  Google Scholar 

  • Geliert M, Hesse JE, Hiom K et al. (1999) V(D)J recombination: links to transposition and double-strand break repair. Cold Spring Harb Symp Quant Biol 64:161–167

    Google Scholar 

  • Gillett CE, Barnes DM (1998) Demystified… cell cycle. Mol Pathol 51:310–316

    PubMed  CAS  Google Scholar 

  • Goedecke W, Eijpe M, Offenberg HH, Aalderen M van, Heyting C (1999) Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat Genet 23:194–198

    PubMed  CAS  Google Scholar 

  • Grana X, Garriga J, Mayol X (1998) Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth. Oncogene 17:3365–3383

    PubMed  Google Scholar 

  • Griffiths SD, Clarke AR, Healy LE et al. (1997) Absence of p53 permits propagation of mutant cells following genotoxic damage. Oncogene 14:523–531

    PubMed  CAS  Google Scholar 

  • Gronbaek K, Nully Brown P de, Moller MB et al. (2000) Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin’s lymphoma. Leukemia 14:1727–1735

    PubMed  CAS  Google Scholar 

  • Groth A, Weber JD, Willumsen BM, Sherr CJ, Roussel MF (2000) Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases. J Biol Chem 275:27.473–27.480

    Google Scholar 

  • Guidez F, Zelent A (2001) Role of nuclear receptor compressors in leukemogenesis. Curr Top Microbiol Immunol 254:165–185

    PubMed  CAS  Google Scholar 

  • Guo A, Salomoni P, Luo J et al. (2000) The function of PML in p53-dependent apoptosis. Nat Cell Biol 2:730–736

    PubMed  CAS  Google Scholar 

  • Gutierrez MI, Cherney B, Hussain A et al. (1999) Bax is frequently compromised in Burkitfs lymphomas with irreversible resistance to Fas-induced apoptosis. Cancer Res 59:696–703

    PubMed  CAS  Google Scholar 

  • Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC (1993) bcl-2-gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 82:1820–1828

    PubMed  CAS  Google Scholar 

  • Hannun YA, Luberto C (2000) Ceramide in the eukaryotic stress response. Trends Cell Biol 10:73–80

    PubMed  CAS  Google Scholar 

  • Harris CA, Johnson EM Jr (2001) Bh3-only bcl-2 family members are coordinately regulated by the jnk pathway and require bax to induce apoptosis in neurons. J Biol Chem 276:37754–37760

    PubMed  CAS  Google Scholar 

  • Harrison CJ (2001) The detection and significance of chromosomal abnormalities in childhood acute lymphoblastic leukaemia. Blood Rev 15:49–59

    PubMed  CAS  Google Scholar 

  • Hay TJ, Meek DW (2000) Multiple sites of in vivo phosphorylation in the MDM 2 oncoprotein cluster within two important functional domains. FEBS Lett 478:183–186

    PubMed  CAS  Google Scholar 

  • Hayashi Y (2000) The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia. Semin Hematol 37:368–380

    PubMed  CAS  Google Scholar 

  • Hecht JL, Aster JC (2000) Molecular biology of Burkitfs lymphoma. J Clin Oncol 18:3707–3721

    PubMed  CAS  Google Scholar 

  • Hemmati PG, Guussen B, Haefen C von et al. (2002) Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene 21:3149–3461

    PubMed  CAS  Google Scholar 

  • Hengstschlager M, Braun K, Soucek T, Miloloza A, Hengstschlager-Ottnad E (1999) Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle. Mutat Res 436:1–9

    PubMed  CAS  Google Scholar 

  • Hickson ID, Davies SL, Li JL et al. (2001) Role of the Bloom’s syndrome helicase in maintenance of genome stability. Biochem Soc Trans 29:201–204

    PubMed  CAS  Google Scholar 

  • Hirano T (2000) Chromosome cohesion, condensation, and separation. Annu Rev Biochem 69:115–144

    PubMed  CAS  Google Scholar 

  • Hochhaus A, Kreil S, Corbin A et al. (2001) Roots of clinical resistance to STI-571 cancer therapy. Science 293:2163

    PubMed  CAS  Google Scholar 

  • Hoeijmakers JH (2001) Genome maintenance mechanisms for preventing cancer. Nature 411:366–374

    PubMed  CAS  Google Scholar 

  • Honda R, Yasuda H (1999) Association of pl9(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J 18:22–27

    PubMed  CAS  Google Scholar 

  • Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc Natl Acad Sci USA 94:12401–12406

    PubMed  CAS  Google Scholar 

  • Hu Y, Ding L, Spencer DM, Nunez G (1998) WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation. J Biol Chem 273:33489–33494

    PubMed  CAS  Google Scholar 

  • Hunt T (1991) Cyclins and their partners: from a simple idea to complicated reality. Semin Cell Biol 2:213–222

    PubMed  CAS  Google Scholar 

  • Ichikawa A, Hotta T, Saito H (1993) Mutations of the p53 gene in B-cell lymphoma. Leuk Lymphoma 11:21–25

    PubMed  CAS  Google Scholar 

  • Inaba T, Inukai T, Yoshihara T et al. (1996) Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature 382:541–544

    PubMed  CAS  Google Scholar 

  • Inohara N, Ding L, Chen S, Nunez G (1997) Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L). EMBO J 16:1686–1894

    PubMed  CAS  Google Scholar 

  • Inukai T, Inoue A, Kurosawa H et al. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell 4:343–352

    PubMed  CAS  Google Scholar 

  • Irwin MS, Kaelin WG (2001) p53 family update: p73 and p63 develop their own identities. Cell Growth Differ 12:337–349

    PubMed  CAS  Google Scholar 

  • Isaacson PG (1999) Mucosa-associated lymphoid tissue lymphoma. Semin Hematol 36:139–147

    PubMed  CAS  Google Scholar 

  • Ivanov EL, Haber JE (1997) DNA repair: RAD alert. Curr Biol 7:R492–R495

    PubMed  CAS  Google Scholar 

  • Jackson SP (1997) DNA-dependent protein kinase. Int J Biochem Cell Biol 29:935–938

    PubMed  CAS  Google Scholar 

  • Jackson CE, Puck JM (1999) Autoimmune lymphoproliferative syndrome, a disorder of apoptosis. Curr Opin Pediatr 11:521–527

    PubMed  CAS  Google Scholar 

  • Jeggo PA (1998) DNA breakage and repair. Adv Genet 38:185–218

    PubMed  CAS  Google Scholar 

  • Jeggo PA, Jackson SP, Taccioli GE (1996) Identification of the catalytic subunit of DNA dependent protein kinase as the product of the mouse Scid gene. Curr Top Microbiol Immunol 217:79–89

    PubMed  CAS  Google Scholar 

  • Jeggo PA, Carr AM, Lehmann AR (1998) Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia. Trends Genet 14:312–316

    PubMed  CAS  Google Scholar 

  • Jiang Y, Woronicz JD, Liu W, Goeddel DV (1999) Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 283:543–546

    PubMed  CAS  Google Scholar 

  • Johnson DG, Schneider-Broussard R (1998) Role of E2F in cell cycle control and cancer. Front Biosci 3:d447–448

    PubMed  CAS  Google Scholar 

  • Johnson DG, Walker CL (1999) Cyclins and cell cycle checkpoints. Annu Rev Pharmacol Toxicol 39:295–312

    PubMed  CAS  Google Scholar 

  • Jost CA, Marin MC, Kaelin WG Jr (1997) p73 is a simian p53-related protein that can induce apoptosis. Nature 389:191–194

    PubMed  CAS  Google Scholar 

  • Jürgensmeier JM, Xie ZH, Deveraux Q, Ellerby L, Bredesen D, Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95:4997–5002

    PubMed  Google Scholar 

  • Kadowaki Y, Fujiwara T, Fukazawa T et al. (1999) Induction of differentiation-dependent apoptosis in human esophageal squamous cell carcinoma by adenovirus-mediated p21sdi1 gene transfer. Clin Cancer Res 5:4233–4241

    PubMed  CAS  Google Scholar 

  • Kaelin WG Jr (1999) Functions of the retinoblastoma protein. Bioessays 21:950–958

    PubMed  Google Scholar 

  • Kaghad M, Bonnet H, Yang A et al. (1997) Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90:809–819

    PubMed  CAS  Google Scholar 

  • Kannan K, Amariglio N, Rechavi G et al. (2001a) DNA microarrays identification of primary and secondary target genes regulated by p53. Oncogene 20:2225–2234

    PubMed  CAS  Google Scholar 

  • Kannan K, Kaminski N, Rechavi G, Jakob-Hirsch J, Amariglio N, Givol D (2001b) DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. Oncogene 20:3449–3455

    PubMed  CAS  Google Scholar 

  • Karin M (1999) How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 18:6867–6874

    PubMed  CAS  Google Scholar 

  • Karin M, Delhase M (2000) The IκB kinase (IKK) and NFjcB: key elements of proinflammatory signalling. Semin Immunol 12:85–98

    PubMed  CAS  Google Scholar 

  • Kasof GM, Gomes BC (2001) Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem 276:3238–3246

    PubMed  CAS  Google Scholar 

  • Kasten MM, Giordano A (1998) pRb and the cdks in apoptosis and the cell cycle. Cell Death Differ 5:132–140

    PubMed  CAS  Google Scholar 

  • Kastan MB, Lim DS (2000) The many substrates and functions of ATM. Nat Rev Mol Cell Biol 1:179–186

    PubMed  CAS  Google Scholar 

  • Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51:6304–6311

    PubMed  CAS  Google Scholar 

  • Katayose Y, Kim M, Rakkar AN, Li Z, Cowan KH, Seth P (1997) Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. Cancer Res 57:5441–5445

    PubMed  CAS  Google Scholar 

  • Kaufmann WK (1995) Cell cycle checkpoints and DNA repair preserve the stability of the human genome. Cancer Metastasis Rev 14:31–41

    PubMed  CAS  Google Scholar 

  • Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239–257

    PubMed  CAS  Google Scholar 

  • Kersey JH, Wang D, Oberto M (1998) Resistance of t(4;11) (MLL-AF4 fusion gene) leukemias to stress-induced cell death: possible mechanism for extensive extramedullary accumulation of cells and poor prognosis. Leukemia 12:1561–1564

    PubMed  CAS  Google Scholar 

  • Keyomarsi KT, Herliczek W (1997) The role of cyclin E in cell proliferation, development and cancer. Prog Cell Cycle Res 3:171–191

    PubMed  CAS  Google Scholar 

  • Kim ST, Lim DS, Canman CE, Kastan MB (1999) Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274:37.538–37.543

    Google Scholar 

  • Kim DR, Park SJ, Oettinger MA (2000) V(D)J recombination: site-specific cleavage and repair. Mol Cells 10:367–374

    PubMed  CAS  Google Scholar 

  • Kischkel FC, Hellbardt S, Behrmann I et al. (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14:5579–5588

    PubMed  CAS  Google Scholar 

  • Kischkel FC, Lawrence DA, Tinel A et al. (2001) Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem 2:2

    Google Scholar 

  • Kitada S, Andersen J, Akar S et al. (1998) Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood 91:3379–3389

    PubMed  CAS  Google Scholar 

  • Kitagawa M, Yamaguchi S, Takahashi M, Tanizawa T, Hirokawa K, Kamiyama R (1998) Localization of Fas and Fas ligand in bone marrow cells demonstrating myelodysplasia. Leukemia 12:486–492

    PubMed  CAS  Google Scholar 

  • Klasa RJ, List AF, Cheson BD (2001) Rational approaches to design of therapeutics targeting molecular markers. Hematology (Am Soc Hematol Educ Program):443–462

    Google Scholar 

  • Kolodner RD, Marsischky GT (1999) Eukaryotic DNA mismatch repair. Curr Opin Genet Dev 9:89–96

    PubMed  CAS  Google Scholar 

  • Krammer PH (2000) CD95’s deadly mission in the immune system. Nature 407:789–795

    PubMed  CAS  Google Scholar 

  • Krammer PH, Behrmann I, Daniel P, Dhein J, Debatin KM (1994) Regulation of apoptosis in the immune system. Curr Opin Immunol 6:279–289

    PubMed  CAS  Google Scholar 

  • Krappmann D, Emmerich F, Kordes U, Scharschmidt E, Dorken B, Scheidereit C (1999) Molecular mechanisms of constitutive NFκB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene 18:943–953

    PubMed  CAS  Google Scholar 

  • Kroemer GJ, Reed C (2000) Mitochondrial control of cell death. Nat Med 6:513–519

    PubMed  CAS  Google Scholar 

  • Kuhnel F, Zender L, Paul Y et al. (2000) NFκB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J Biol Chem 275:6421–6427

    PubMed  CAS  Google Scholar 

  • Kuntzel H, Schulz A, Ehbrecht IM (1996) Cell cycle control and initiation of DNA replication in Saccharomyces cerevisiae. Biol Chem 377:481–487

    PubMed  CAS  Google Scholar 

  • Kurotaki H, Tsushima Y, Nagai K, Yagihashi S (2000) Apoptosis, bcl-2 expression and p53 accumulation in myelodysplastic syndrome, myelodysplastic-syndrome-derived acute myelogenous leukemia and de novo acute myelogenous leukemia. Acta Haematol 102:115–123

    PubMed  CAS  Google Scholar 

  • Larner JM, Lee H, Hamlin JL (1997) S phase damage sensing checkpoints in mammalian cells. Cancer Surv 29:25–45

    PubMed  CAS  Google Scholar 

  • Lee H, Arsura M, Wu M, Duyao M, Buckler AJ, Sonenshein GE (1995) Role of Rel-related factors in control of c-myc-gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J Exp Med 181:1169–1177

    PubMed  CAS  Google Scholar 

  • Lenny N, Westendorf JJ, Hiebert SW (1997) Transcriptional regulation during myelopoiesis. Mol Biol Rep 24:157–168

    PubMed  CAS  Google Scholar 

  • Li AJ, Blow J (2001) The origin of CDK regulation. Nat Cell Biol 3:E182–184

    PubMed  CAS  Google Scholar 

  • Li P, Nijhawan D, Budihardjo I et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-l/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479–489

    PubMed  CAS  Google Scholar 

  • Li F, Ackermann EJ, Bennett CF et al. (1999) Pleiotropic celldivision defects and apoptosis induced by interference with survivin function. Nat Cell Biol 1:461–466

    PubMed  CAS  Google Scholar 

  • Lieber MR, Grawunder U, Wu X, Yaneva M (1997) Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr Opin Genet Dev 7:99–104

    PubMed  CAS  Google Scholar 

  • Lim DS, Kim ST, Xu B et al. (2000) ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404:613–617

    PubMed  CAS  Google Scholar 

  • Lin AW, Lowe SW (2001) Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Nati Acad Sci USA 98:5025–5030

    CAS  Google Scholar 

  • Liu Q, Guntuku S, Cui XS et al. (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 14:1448–1459

    PubMed  CAS  Google Scholar 

  • Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A et al. (2001) Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet 357:39–40

    PubMed  CAS  Google Scholar 

  • Loeb LA, Kunkel TA (1982) Fidelity of DNA synthesis. Annu Rev Biochem 51:429–457

    PubMed  CAS  Google Scholar 

  • Lowe SW (1995) Cancer therapy and p53. Curr Opin Oncol 7:547–553

    PubMed  CAS  Google Scholar 

  • Lucas PC, Yonezumi M, Inohara N et al. (2001) Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NFκB signaling pathway. J Biol Chem 276:19012–19019

    PubMed  CAS  Google Scholar 

  • Luo X, Budihardjo I, Zou H, Slaughter C, Wang X (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481–490

    PubMed  CAS  Google Scholar 

  • Lydall D, Weinert T (1996) From DNA damage to cell cycle arrest and suicide: a budding yeast perspective. Curr Opin Genet Dev 6:4–11

    PubMed  CAS  Google Scholar 

  • Maaser K, Hopfner M, Jansen A et al. (2001) Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer 85:1771–1780

    PubMed  CAS  Google Scholar 

  • Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NFκB. Mol Cell Biol 20:1626–1638

    PubMed  CAS  Google Scholar 

  • Malumbres M, Pellicer A (1998) RAS pathways to cell cycle control and cell transformation. Front Biosci 3:d887–912

    PubMed  CAS  Google Scholar 

  • Martinou JC, Green DR (2001) Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2:63–67

    PubMed  CAS  Google Scholar 

  • Matsuoka S, Huang M, Elledge S J (1998) Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282:1893–1897

    PubMed  CAS  Google Scholar 

  • Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 97:10389–10394

    PubMed  CAS  Google Scholar 

  • Mauro MJ, Druker BJ (2001) STI571: a gene product-targeted therapy for leukemia. Curr Oncol Rep 3:223–227

    PubMed  CAS  Google Scholar 

  • McCormick F (2000) Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015. Semin Cancer Biol 10:453–459

    PubMed  CAS  Google Scholar 

  • McDonnell TJ, Korsmeyer S J (1991) Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature 349:254–256

    PubMed  CAS  Google Scholar 

  • McDonnell TJ, Deane N, Piatt FM et al. (1989) Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57:79–88

    PubMed  CAS  Google Scholar 

  • McMurray HR, Nguyen D, Westbrook TF, McAnce DJ (2001) Biology of human papillomaviruses. Int J Exp Pathol 82:15–33

    PubMed  CAS  Google Scholar 

  • Meier P, Finch A, Evan G (2000) Apoptosis in development. Nature 407:796–801

    PubMed  CAS  Google Scholar 

  • Millar JB, Russell P (1992) The cdc25 M-phase inducer: an unconventional protein phosphatase. Cell 68:407–410

    PubMed  CAS  Google Scholar 

  • Moberg KH, Bell DW, Wahrer DC, Haber DA, Hariharan IK (2001) Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413:311–316

    PubMed  CAS  Google Scholar 

  • Molinari M (2000) Cell cycle checkpoints and their inactivation in human cancer. Cell Prolif 33:261–274

    PubMed  CAS  Google Scholar 

  • Morgan SE, Kastan MB (1997) p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res 71:1–25

    PubMed  CAS  Google Scholar 

  • Moser BA, Russell P (2000) Cell cycle regulation in Schizosaccharomyces pombe. Curr Opin Microbiol 3:631–636

    PubMed  CAS  Google Scholar 

  • Muller H, Heiin K (2000) The E2F transcription factors: key regulators of cell proliferation. Biochim Biophys Acta 1470:M1–12

    PubMed  CAS  Google Scholar 

  • Müller H, Bracken AP, Vernell R et al. (2001) E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev 15:267–285

    PubMed  Google Scholar 

  • Muzio M, Chinnaiyan AM, Kischkel FC et al. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817–827

    PubMed  CAS  Google Scholar 

  • Nagamura-Inoue T, Tamura T, Ozato K (2001) Transcription factors that regulate growth and differentiation of myeloid cells. Int Rev Immunol 20:83–105

    PubMed  CAS  Google Scholar 

  • Nagata S (1998) Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model. J Hum Genet 43:2–8

    PubMed  CAS  Google Scholar 

  • Nakagawa T, Zhu H, Morishima N et al. (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98–103

    PubMed  CAS  Google Scholar 

  • Nakano K, Wousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683–694

    PubMed  CAS  Google Scholar 

  • Nesbit CE, Tersak JM, Prochownik EV (1999) MYC oncogenes and human neoplastic disease. Oncogene 18:3004–3016

    PubMed  CAS  Google Scholar 

  • Nicholson DW (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 6:1028–1042

    PubMed  CAS  Google Scholar 

  • Nigg EA (2001) Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2:21–32

    PubMed  CAS  Google Scholar 

  • Nilsson I, Hoffmann I (2000) Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res 4:107–114

    PubMed  CAS  Google Scholar 

  • O’Connor L, Strasser A, O’Reilly LA et al. (1998) Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17:384–395

    PubMed  Google Scholar 

  • Oda E, Ohki R, Murasawa H et al. (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288:1053–1058

    PubMed  CAS  Google Scholar 

  • Ohi R, Gould KL (1999) Regulating the onset of mitosis. Curr Opin Cell Biol 11:267–273

    PubMed  CAS  Google Scholar 

  • Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609–619

    PubMed  CAS  Google Scholar 

  • Osada M, Ohba M, Kawahara C et al. (1998) Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat Med 4:839–843

    PubMed  CAS  Google Scholar 

  • Pandolfi PP (2001) Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Hum Mol Genet 10:769–775

    PubMed  CAS  Google Scholar 

  • Parker JE, Mufti GJ (2001) The role of apoptosis in the pathogenesis of the myelodysplastic syndromes. Int J Hematol 73:416–428

    PubMed  CAS  Google Scholar 

  • Peltomaki P (2001) DNA mismatch repair and cancer. Mutat Res 488:77–85

    PubMed  CAS  Google Scholar 

  • Perez D, White E (1998) E1B 19 K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE. J Cell Biol 141:1255–1266

    PubMed  CAS  Google Scholar 

  • Perkins ND (2000) The Rel/NFκB family: friend and foe. Trends Biochem Sci 25:434–440

    PubMed  CAS  Google Scholar 

  • Peters JM (1999) Subunits and substrates of the anaphase-promoting complex. Exp Cell Res 248:339–349

    PubMed  CAS  Google Scholar 

  • Petrini JH (2000) The Mre11 complex and ATM: collaborating to navigate S phase. Curr Opin Cell Biol 12:293–296

    PubMed  CAS  Google Scholar 

  • Pinyol M, Cobo F, Bea S et al. (1998) pl6(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin’s lymphomas. Blood 91:2977–2984

    PubMed  CAS  Google Scholar 

  • Pipas JM, Levine AJ (2001) Role of T antigen interactions with p53 in tumorigenesis. Semin Cancer Biol 11:23–30

    PubMed  CAS  Google Scholar 

  • Polster BM, Kinnally KW, Fiskum G (2001) BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J Biol Chem 276:37887–37894

    PubMed  CAS  Google Scholar 

  • Prokop A, Wieder T, Sturm I et al. (2000) Relapse in childhood acute lymphoblastic leukemia is associated with decrease of Bax/Bcl-2-ratio and loss of spontaneous caspase-3 processing in vivo. Leukemia 14:1606–1613

    PubMed  CAS  Google Scholar 

  • Putcha GV, Moulder KL, Golden JP et al. (2001) Induction of BIM, a proapoptotic BH3-only Bcl-2 family member, is critical for neuronal apoptosis. Neuron 29:615–628

    PubMed  CAS  Google Scholar 

  • Puthalakath H, Huang DC, O’Reilly LA, King SM, Strasser A (1999) The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3:287–296

    PubMed  CAS  Google Scholar 

  • Puthalakath H, Villunger A, O’Reilly LA et al. (2001) Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293:1829–1832

    PubMed  CAS  Google Scholar 

  • Radetzki S, Könne CH, Haefen C von et al. (2002) The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1 overexpressing breast cancer cell lines. Oncogene 21:227–238

    PubMed  CAS  Google Scholar 

  • Raisova M, Bektas M, Wieder T et al. (2000) Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. FEBS Lett 473:27–32

    PubMed  CAS  Google Scholar 

  • Raisova M, Hossini AM, Eberle J et al. (2001) The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. J Invest Dermatol 117:333–340

    PubMed  CAS  Google Scholar 

  • Rajapaksa R, Ginzton N, Rott LS, Greenberg PL (1996) Altered oncoprotein expression and apoptosis in myelodysplastic syndrome marrow cells. Blood 88:4275–4287

    PubMed  CAS  Google Scholar 

  • Rampino N, Yamamoto H, Ionov Y et al. (1997) Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275:967–969

    PubMed  CAS  Google Scholar 

  • Rao RV, Hermel E, Castro-Obregon S et al. (2001) Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 276: 33869–33874

    PubMed  CAS  Google Scholar 

  • Rauen M, Burtelow MA, Dufault VM, Karnitz LM (2000) The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. J Biol Chem 275:29767–29771

    PubMed  CAS  Google Scholar 

  • Rayet B, Gelinas C (1999) Aberrant rel/NFκB genes and activity in human cancer. Oncogene 18:6938–6947

    PubMed  CAS  Google Scholar 

  • Rhind N, Russell P (1998) Mitotic DNA damage and replication checkpoints in yeast. Curr Opin Cell Biol 10:749–758

    PubMed  CAS  Google Scholar 

  • Rhind N, Russell P (2000) Checkpoints: it takes more than time to heal some wounds. Curr Biol 10:R908–911

    PubMed  CAS  Google Scholar 

  • Rhind N, Russell P (2001) Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints. Mol Cell Biol 21:1499–1508

    PubMed  CAS  Google Scholar 

  • Richter BW, Mir SS, Eiben LJ et al. (2001) Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Mol Cell Biol 21:4292–4301

    PubMed  CAS  Google Scholar 

  • Rodenhuis S (1992) ras and human tumors. Semin Cancer Biol 3:241–247

    PubMed  CAS  Google Scholar 

  • Roovers KR, Assoian K (2000) Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays 22:818–826

    PubMed  CAS  Google Scholar 

  • Roussel MF (1999) The INK4 family of cell cycle inhibitors in cancer. Oncogene 18:5311–5317

    PubMed  CAS  Google Scholar 

  • Rozenfeld-Granot G, Toren A, Amariglio N, Brok-Simoni F, Rechavi G (2001) Mutation analysis of the FAS and TNFR apoptotic cascade genes in hematological malignancies. Exp Hematol 29:228–233

    PubMed  CAS  Google Scholar 

  • Rubnitz JE, Pui CH, Downing JR (1999) The role of TEL fusion genes in pediatric leukemias. Leukemia 13:6–13

    PubMed  CAS  Google Scholar 

  • Russell P (1998) Checkpoints on the road to mitosis. Trends Biochem Sci 23:399–402

    PubMed  CAS  Google Scholar 

  • Ryan KM, Ernst MK, Rice NR, Vousden KH (2000) Role of NFκB in p53-mediated programmed cell death. Nature 404:892–897

    PubMed  CAS  Google Scholar 

  • Sakai A, Thieblemont C, Wellmann A, Jaffe ES, Raffeid M (1998) PTEN gene alterations in lymphoid neoplasms. Blood 92:3410–3415

    PubMed  CAS  Google Scholar 

  • Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S (1999) Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J 18:2040–2048

    PubMed  CAS  Google Scholar 

  • Sanchez Y, Wong C, Thoma RS et al. (1997) Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277:1497–1501

    PubMed  CAS  Google Scholar 

  • Sandig V, Brand K, Herwig S, Lukas J, Bartek J, Strauss M (1997) Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Nat Med 3:313–319

    PubMed  CAS  Google Scholar 

  • Savill J, Fadok V (2000) Corpse clearance defines the meaning of cell death. Nature 407:784–788

    PubMed  CAS  Google Scholar 

  • Sawyers CL (1997) Signal transduction pathways involved in BCR-ABL transformation. Baillieres Clin Haematol 10:223–231

    PubMed  CAS  Google Scholar 

  • Scheid MP, Duronio V (1998) Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. Proc Natl Acad Sci USA 95:7439–7444

    PubMed  CAS  Google Scholar 

  • Schmitt CA, McCurrach ME, Stanchina E de, Wallace-Brodeur RR, Lowe SW (1999) INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 13:2670–2677

    PubMed  CAS  Google Scholar 

  • Schwab M, Tyers M (2001) Cell cycle. Archipelago of destruction. Nature 413:268–269

    PubMed  CAS  Google Scholar 

  • Senderowicz AM (2000) Small molecule modulators of cyclin-dependent kinases for cancer therapy. Oncogene 19:6600–6606

    PubMed  CAS  Google Scholar 

  • Serrano M (2000) The INK4a/ARF locus in murine tumorigenesis. Carcinogenesis 21:865–869

    PubMed  CAS  Google Scholar 

  • Shaul Y (2000) c-Abl: activation and nuclear targets. Cell Death Differ 7:10–16

    PubMed  CAS  Google Scholar 

  • Sherr CJ, Roberts JM (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501–1512

    PubMed  CAS  Google Scholar 

  • Sherr CJ, Weber JD (2000) The ARF/p53 pathway. Curr Opin Genet Dev 10:94–99

    PubMed  CAS  Google Scholar 

  • Shimizu S, Ide T, Yanagida T, Tsujimoto Y (2000a) Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem 275:12.321–12.325

    Google Scholar 

  • Shimizu S, Shinohara Y, Tsujimoto Y (2000b) Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene 19:4309–4318

    PubMed  CAS  Google Scholar 

  • Siebert R, Willers CP, Opalka B (1996) Role of the cyclin-dependent kinase 4 and 6 inhibitor gene family p15, p16, p18 and p19 in leukemia and lymphoma. Leuk Lymphoma 23:505–520

    PubMed  CAS  Google Scholar 

  • Sigalas I, Calvert AH, Anderson JJ, Neal DE, Lunec J (1996) Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer. Nat Med 2:912–917

    PubMed  CAS  Google Scholar 

  • Skibbens RV, Hieter P (1998) Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery. Annu Rev Genet 32:307–337

    PubMed  CAS  Google Scholar 

  • Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91:209–219

    PubMed  CAS  Google Scholar 

  • Smider V, Chu G (1997) The end-joining reaction in V(D)J recombination. Semin Immunol 9:189–197

    PubMed  CAS  Google Scholar 

  • Smits VA, Medema RH (2001) Checking out the G(2)/M transition. Biochim Biophys Acta 1519:1–12

    PubMed  CAS  Google Scholar 

  • Soengas MS, Alarcon RM, Yoshida H et al. (1999) Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284:156–159

    PubMed  CAS  Google Scholar 

  • Soengas MS, Capodieci P, Polsky D et al. (2001) Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409:207–211

    PubMed  CAS  Google Scholar 

  • Soussi T, Jonveaux P (1991) p53 gene alterations in human hematological malignancies: a review. Nouv Rev Fr Hematol 33:477–480

    PubMed  CAS  Google Scholar 

  • Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998) Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1:949–957

    PubMed  CAS  Google Scholar 

  • Srinivasula SM, Hegde R, Saleh A et al. (2001) A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410:112–116

    PubMed  CAS  Google Scholar 

  • Stambolic V, Mak TW, Woodgett JR (1999) Modulation of cellular apoptotic potential: contributions to oncogenesis. Oncogene 18:6094–103

    PubMed  CAS  Google Scholar 

  • Stern B, Nurse P (1996) A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet 12:345–350

    PubMed  CAS  Google Scholar 

  • Strohmaier H, Spruck CH, Kaiser P, Won KA, Sangfelt O, Reed SI (2001) Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413:316–322

    CAS  Google Scholar 

  • Sturm I, Kohne CH, Wolff G et al. (1999) Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol 17:1364–1374

    PubMed  CAS  Google Scholar 

  • Sturm I, Papadopoulos S, Hillebrand T et al. (2000) Impaired BAX protein expression in breast cancer: mutational analysis of the BAX and the p53 gene. Int J Cancer 87:517–521

    PubMed  CAS  Google Scholar 

  • Sturm I, Petrowsky H, Volz R et al. (2001) Analysis of p53/BAX/p16ink4a/CDKN2 in esophageal squamous cell carcinoma: high BAX and p16ink4a/CDKN2 identifies patients with good prognosis. J Clin Oncol 19:2272–2281

    PubMed  CAS  Google Scholar 

  • Subramanian T, Tarodi B, Chinnadurai G (1995) Functional similarity between adenovirus E1B 19-kDa protein and proteins encoded by Bcl-2 proto-oncogene and Epstein-Barr virus BHRF1 gene. Curr Top Microbiol Immunol 199:153–161

    PubMed  CAS  Google Scholar 

  • Suda T, Takahashi T, Golstein P, Nagata S (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169–1178

    PubMed  CAS  Google Scholar 

  • Susin SA, Lorenzo HK, Zamzami N et al. (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441–446

    PubMed  CAS  Google Scholar 

  • Suzuki R, Kuroda H, Komatsu H et al. (1999) Selective usage of D-type cyclins in lymphoid malignancies. Leukemia 13:1335–1342

    PubMed  CAS  Google Scholar 

  • Takizawa CG, Morgan DO (2000) Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol 12:658–665

    PubMed  CAS  Google Scholar 

  • Tamrakar S, Rubin E, Ludlow JW (2000) Role of pRB dephosphorylation in cell cycle regulation. Front Biosci 5:D121–137

    PubMed  CAS  Google Scholar 

  • Tan B, Piwnica-Worms D, Ratner L (2000) Multidrug resistance transporters and modulation. Curr Opin Oncol 12:450–458

    PubMed  CAS  Google Scholar 

  • Taylor SS, McKeon F (1997) Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell 89:727–735

    PubMed  CAS  Google Scholar 

  • Taylor WR, Stark GR (2001) Regulation of the G2/M transition by p53. Oncogene 20:1803–1815

    PubMed  CAS  Google Scholar 

  • Teofili L, Martini M, Di Mario A et al. (2001) Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors. Blood 98:495–497

    PubMed  CAS  Google Scholar 

  • Tibbetts RS, Cortez D, Brumbaugh KM et al. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev 14:2989–3002

    PubMed  CAS  Google Scholar 

  • Tschan MP, Grob TJ, Peters UR et al. (2000) Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid leukemia. Biochem Biophys Res Commun 277:62–65

    PubMed  CAS  Google Scholar 

  • Tschopp J, Martinon F, Hofmann K (1999) Apoptosis: silencing the death receptors. Curr Biol 9:R381–R384

    PubMed  CAS  Google Scholar 

  • Tsujimoto Y, Shimizu S (2000) VDAC regulation by the Bcl-2 family of proteins. Cell Death Differ 7:1174–1181

    PubMed  CAS  Google Scholar 

  • Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097–1099

    PubMed  CAS  Google Scholar 

  • Tsujimoto Y, Cossman J, Jaffe E, Croce CM (1985) Involvement of the bcl-2-gene in human follicular lymphoma. Science 228:1440–1443

    PubMed  CAS  Google Scholar 

  • Tzivion G, Avruch J (2001) 14–3–3 Proteins: active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem 14:14

    Google Scholar 

  • Vandenberghe E, De Wolf-Peeters C, van den Oord J et al. (1991) Translocation (11;14): a cytogenetic anomaly associated with B-cell lymphomas of non-follicle centre cell lineage. J Pathol 163:13–18

    PubMed  CAS  Google Scholar 

  • Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440–442

    PubMed  CAS  Google Scholar 

  • Venkitaraman AR (2001) Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J Cell Sci 114:3591–3598

    PubMed  CAS  Google Scholar 

  • Vidal A, Koff A (2000) Cell-cycle inhibitors: three families united by a common cause. Gene 247:1–15

    PubMed  CAS  Google Scholar 

  • Vieira HL, Haouzi D, El Hamel C et al. (2000) Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator. Cell Death Differ 7:1146–1154

    PubMed  CAS  Google Scholar 

  • Wagener C, Bargou RC, Daniel PT et al. (1996) Induction of the death-promoting gene bax-alpha sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int J Cancer 67:138–141

    PubMed  CAS  Google Scholar 

  • Waldman T, Lengauer C, Kinzler KW, Vogelstein B (1996) Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381:713–716

    PubMed  CAS  Google Scholar 

  • Wang JY (2000) Regulation of cell death by the Abl tyrosine kinase. Oncogene 19:5643–5650

    PubMed  CAS  Google Scholar 

  • Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ (1996) BID: a novel BH3 domain-only death agonist. Genes Dev 10:2859–2869

    PubMed  CAS  Google Scholar 

  • Wang ZG, Ruggero D, Ronchetti S et al. (1998) PML is essential for multiple apoptotic pathways. Nat Genet 20:266–272

    PubMed  CAS  Google Scholar 

  • Wang H, Liu D, Wang Y, Qin J, Elledge S J (2001) Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev 15:1361–1372

    PubMed  CAS  Google Scholar 

  • Weber JD, Jeffers JR, Rehg JE et al. (2000) p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev 14:2358–2365

    PubMed  CAS  Google Scholar 

  • Westendorp MO, Frank R, Ochsenbauer C et al. (1995) Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gpl20. Nature 375:497–500

    PubMed  CAS  Google Scholar 

  • Whiteside D, McLeod R, Graham G et al. (2002) A homozygous germ-line mutation in the human msh2 gene predisposes to hematological malignancy and multiple caféau-lait spots. Cancer Res 62:359–362

    PubMed  CAS  Google Scholar 

  • Whitman SP, Archer KJ, Feng L et al. (2001) Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res 61:7233–7239

    PubMed  CAS  Google Scholar 

  • Wieder T, Essmann F, Prokop A et al. (2001) Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor ligand interaction and occurs downstream of caspase-3. Blood 97:1378–1387

    PubMed  CAS  Google Scholar 

  • Wiley SR, Schooley K, Smolak PJ et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673–682

    PubMed  CAS  Google Scholar 

  • Willis TG, Jadayel DM, Du MQ et al. (1999) Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96:35–45

    PubMed  CAS  Google Scholar 

  • Wind N de, Dekker M, Claij N et al. (1999) HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. Nat Genet 23:359–362

    PubMed  Google Scholar 

  • Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (1999) A family of mammalian F-box proteins. Curr Biol 9:1180–1182

    PubMed  CAS  Google Scholar 

  • Wu J, Gu L, Wang H, Geacintov NE, Li GM (1999) Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis. Mol Cell Biol 19:8292–8301

    PubMed  CAS  Google Scholar 

  • Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555–556

    PubMed  CAS  Google Scholar 

  • Wyllie AH, Bellamy CO, Bubb VJ et al. (1999) Apoptosis and carcinogenesis. Br J Cancer 80:34–37

    PubMed  Google Scholar 

  • Yamada KM, Araki M (2001) Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis. J Cell Sci 114:2375–2382

    PubMed  CAS  Google Scholar 

  • Yamaguchi H, Inokuchi K, Sakuma Y, Dan K (2001) Mutation of the p51/p63 gene is associated with blastic crisis in chronic myelogenous leukemia. Leukemia 15:1729–1734

    PubMed  CAS  Google Scholar 

  • Yamamoto YR, Gaynor B (2001) Therapeutic potential of inhibition of the NFκB pathway in the treatment of inflammation and cancer. J Clin Invest 107:135–142

    PubMed  CAS  Google Scholar 

  • Yamasaki L (1999) Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action. Biochim Biophys Acta 1423-.M9–15

    Google Scholar 

  • Yang E, Zha J, Jockei J, Boise LH, Thompson CB, Korsmeyer SJ (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285–291

    PubMed  CAS  Google Scholar 

  • Yang J, Liu X, Bhalla K et al. (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129–1132

    PubMed  CAS  Google Scholar 

  • Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchim Oren A (1991) Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352:345–347

    PubMed  CAS  Google Scholar 

  • Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7:673–682

    PubMed  CAS  Google Scholar 

  • Zha J, Harada H, Yang E, Jockei J, Korsmeyer SJ (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14–3–3 not Bcl-X(L). Cell 87:619–628

    PubMed  CAS  Google Scholar 

  • Zhang H, Richards B, Wilson T et al. (1999) Apoptosis induced by overexpression of hMSH2 or hMLH1. Cancer Res 59:3021–3027

    PubMed  CAS  Google Scholar 

  • Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z (2001) Arsenic trioxide, a therapeutic agent for APL. Oncogene 20:7146–7153

    PubMed  CAS  Google Scholar 

  • Zhong S, Salomoni P, Ronchetti S, Guo A, Ruggero D, Pandolfi PP (2000) Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J Exp Med 191:631–640

    PubMed  CAS  Google Scholar 

  • Zhou BB, Elledge SJ (2000) The DNA damage response: putting checkpoints in perspective. Nature 408:433–439

    PubMed  CAS  Google Scholar 

  • Zhou M, Gu L, Abshire TC et al. (2000) Incidence and prognostic significance of MDM 2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia. Leukemia 14:61–67

    PubMed  CAS  Google Scholar 

  • Zhu J, Koken MH, Quignon F et al. (1997) Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia. Proc Natl Acad Sci USA 94:3978–983

    PubMed  CAS  Google Scholar 

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Authors
  1. Peter Daniel
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Intitut für Zell- und Molekularpathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30623, Hannover, Deutschland

    Brigitte Schlegelberger

  3. Medizinische Fakultät, Institut für Medizinische Biologie, Universität Wien, Währinger Gürtel 10, A-1090, Wien IX, Österreich

    Christa Fonatsch

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Meinem Vater, Werner Daniel (⋆21. 2. 1925 † 12. 6. 1999

Denn wir sind nur die Schale und das Blatt Der grße Tod, den jeder in sich hat, das ist die Frucht, um die sich alles dreht.

R.M Rilke

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Daniel, P. (2003). Zellzyklus und Apoptose. In: Ganten, D., Ruckpaul, K., Schlegelberger, B., Fonatsch, C. (eds) Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59343-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-59343-7_5

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