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Molecular Tools in the Detection of Micrometastatic Cancer Cells — Technical Aspects and Clinical Relevance

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Minimal Residual Disease in Melanoma

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 158))

Abstract

The frequent failure to reduce the mortality due to epithelial cancers by common medical intervention results primarily from early dissemination of cancer cells, which is missed by conventional diagnostic procedures used for tumor staging. Individual carcinoma cells present in regional lymph nodes, blood or distant organs (e.g., bone marrow) can be detected by sensitive immunologic or molecular methods. Here, we review recently developed molecular assays for the detection of individual micrometastatic cancer cells and their clinical application in patients with epithelial tumors.

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Authors and Affiliations

  1. Division for Molecular Diagnostics and Therapy, Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    M. von Knebel Doeberitz, J. Weitz, M. Koch, J. Lacroix, A. Schrödel & C. Herfarth

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  1. M. von Knebel Doeberitz
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  2. J. Weitz
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  3. M. Koch
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  4. J. Lacroix
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  5. A. Schrödel
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  6. C. Herfarth
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Editors and Affiliations

  1. Universitätskliniken des Saarlandes Haut- und Poliklinik, 66421, Homburg/Saar, Germany

    Uwe Reinhold  & Wolfgang Tilgen  & 

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© 2001 Springer-Verlag Berlin · Heidelberg

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von Knebel Doeberitz, M., Weitz, J., Koch, M., Lacroix, J., Schrödel, A., Herfarth, C. (2001). Molecular Tools in the Detection of Micrometastatic Cancer Cells — Technical Aspects and Clinical Relevance. In: Reinhold, U., Tilgen, W. (eds) Minimal Residual Disease in Melanoma. Recent Results in Cancer Research, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59537-0_18

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  • DOI: https://doi.org/10.1007/978-3-642-59537-0_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64015-5

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