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Angiogene Wachstumsfaktoren und humanes Herpesvirus-8: Schlüsselregulatoren der AIDS-assoziierten Vaskulopathie

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HIV-Infekt

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Zusammenfassung

Pathologische Gefäßveränderungen (AIDS-assoziierte Vaskulopathie), insbesondere das Kaposi-Sarkom (KS), stellen wesentliche klinische Ausprägungen der AIDS-Erkrankung dar. Im Rahmen dieser Arbeit konnte anhand von in vivo-Untersuchungen eine Beteiligung von vascular endothelial cell growth factor (VEGF) bei der AIDS-assoziierten Vaskulopathie belegt werden. Darüberhinaus konnte die Rolle eines neu entdeckten humanen Herpesvirus, HHV-8, in der KS-Entwicklung eingegrenzt werden. In situ-Untersuchungen zur HHV-8-Genexpression in KS-Biopsien deuten darauf hin, daß dieses Virus vor allem die KS-Progression und weniger die Initiation beeinflußt. Hierbei könnte ein Viruskodiertes Cyclin D-homologes Protein, welches in latent infizierten KS-Spindelzellen exprimiert wird, einen wichtigen Progressionsfaktor darstellen.

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Authors
  1. M. Stürzl
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  2. G. Ascherl
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  3. E. Tschachler
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  4. P. Monini
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  5. B. Ensoli
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  6. C. Hohenadl
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Editors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Ruhr-Universität Bochum, Gudrunstraße 56, Deutschland

    Norbert H. Brockmeyer , Klaus Hoffmann , G. Reimann , Markus Stücker  & Peter Altmeyer , , ,  & 

  2. Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland

    R. Brodt

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© 2000 Springer-Verlag Berlin Heidelberg

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Stürzl, M., Ascherl, G., Tschachler, E., Monini, P., Ensoli, B., Hohenadl, C. (2000). Angiogene Wachstumsfaktoren und humanes Herpesvirus-8: Schlüsselregulatoren der AIDS-assoziierten Vaskulopathie. In: Brockmeyer, N.H., Hoffmann, K., Reimann, G., Stücker, M., Altmeyer, P., Brodt, R. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59683-4_16

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  • DOI: https://doi.org/10.1007/978-3-642-59683-4_16

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