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Cell Death

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Drug Toxicity in Embryonic Development I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 124 / 1))

Abstract

One of the major challenges facing teratologists is the elucidation of mechanisms by which birth defects occur. This requires an understanding of the primary targets of physiological and environmental agents that affect the health and well-being of the conceptus, the cellular events of pathogenesis, and the genes which place the embryo at risk. Cell death is gene-directed event in the developing embryo. Its’ broad phylogenetic representation is consistent with a selective advantage in development for the involution of vestigial structures which have importance in phylogenetic but not ontogenetic development, reduction of superfluous cells, disposal of cells that have already completed their functions, elimination of cells which differentiate inappropriately, and suppression of potentially harmful or abnormal cells (Saunders 1966; Ellis et al 1991).

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Authors
  1. T. B. Knudsen
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  1. Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA

    Robert J. Kavlock Ph.D. (Director) (Director)

  2. Miami Valley Laboratories, The Procter and Gamble Company, P.O. Box 538707, 45253, Cincinnati, OH, USA

    George P. Daston Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Knudsen, T.B. (1997). Cell Death. In: Kavlock, R.J., Daston, G.P. (eds) Drug Toxicity in Embryonic Development I. Handbook of Experimental Pharmacology, vol 124 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60445-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-60445-4_8

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