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Platelet Protein Tyrosine Kinases

  • Chapter
Platelets and Their Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 126))

Abstract

The first protein tyrosine kinase (PTK) to be identified, detected by Hunter and Sefton in 1979, was the transforming protein of the Rous sarcoma virus (Hunter and Sefton 1980). This 60-kDa phosphoprotein is encoded by the viral src oncogene (v-src) and is denoted pp60v-src. Retroviral oncogenes simply represent oncogenic forms of cellular genes, which are termed protooncogenes (Bishop 1983). Although the first PTKs were identified as transforming proteins, the great majority of cellular genes encoding PTKs were discovered by screening cDNA libraries for genetic sequence homology. Meanwhile, it has become clear that most of the cellular PTKs fall into one of two classes. The first class consists of receptor PTKs that mediate signalling by many growth factors and polypeptide hormones such as insulin and neurotrophins (Fantl et al. 1993; Van Der Geer et al. 1994). The members of the second class are defined by their intracellular localization and lack of extracellular receptor and transmembrane domains. These enzymes are termed intracellular — or more commonly — nonreceptor PTKs.

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Authors
  1. P. Presek
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  2. E. A. Martinson
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Editors and Affiliations

  1. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69-73, 14195, Berlin, Germany

    Franz von Bruchhausen

  2. Institut für Klinische Biochemie und Pathobiochemie, Medinzinische Universitätsklinik, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Ulrich Walter

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Presek, P., Martinson, E.A. (1997). Platelet Protein Tyrosine Kinases. In: von Bruchhausen, F., Walter, U. (eds) Platelets and Their Factors. Handbook of Experimental Pharmacology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60639-7_13

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