Abstract
The development of neuronal and glial cells in the mammalian central nervous system requires the coordinate expression of cell type-specific subsets of genes. When development has been completed, fully differentiated cells maintain their characteristic properties by continously integrating cell-intrinsic and -extrinsic signals which converge, ultimately, at the level of gene transcription. This integration is executed by the combined activity of cell type-specific and ubiquitous transcription factors, but the underlying combinatorial code is little understood. In such regulatory systems, the repression of some genes is as important as specific gene activation. Autoregulative circuits, which include both transcriptional activators and repressors, are thought to stabilize the phenotype of each cell. To better understand the molecular mechanisms which underlie normal development and differentiation of the nervous system, it is essential to identify the key players in gene transcription. This also applies to the understanding of regenerative processes, which are thought to recapitulate, at least in part, the steps of normal development.
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Rossner, M., Bartholomä, A., Schwab, M., Nave, KA. (1997). Molecular cloning of new basic helix-loop-helix proteins from the mammalian central nervous system. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_19
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DOI: https://doi.org/10.1007/978-3-642-60669-4_19
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