Skip to main content
SpringerLink
Log in

Diagnostic Tools and Clinical Pathology

  • Chapter
Drug-Induced Hepatotoxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 121))

  • 205 Accesses

Abstract

Hepatic drug reactions occur in a variety of clinical settings. In many cases the association of liver disease with the use of a particular drug is obvious because of a temporal association of developing liver function abnormalities to beginning use of the drug. This scenario generally leads to discontinuation of the drug and resolution of the dysfunction. In this setting biopsy is rarely indicated. With many drugs there is no long-term consequence as long as the drug is not reintroduced.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alpert LI(1976) Veno-occlusive disease of the liver associated with oral contraceptives. Case report and review of literature. Hum Pathol 7:709–718

    CAS  Google Scholar 

  • Altraif I, Lilly L, Wanless IR, Heathcote J(1994) Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole. Am J GastroenteroI 89:1230–1234

    CAS  Google Scholar 

  • Bird D, Vowles K, Anthony PP(1979) Spontaneous rupture of a liver cell adenoma after long term methyltestosterone. Report of a case treated by emergency right hepatic lobectomy. Br J Surg 66:212–213

    CAS  Google Scholar 

  • Black M, Mitchell JR, Zimmerman HJet al.(1975) Isoniazid associated hepatitis in 114 patients. Gastroenterology 69:289–302

    PubMed  CAS  Google Scholar 

  • Bramlet DA, Posalaky Z, Olson R(1980) Granulomatous hepatitis as a manifestation of quinidine hypersensitivity. Arch Intern Med 140:395–397

    Article  PubMed  CAS  Google Scholar 

  • Craig JR, Peters RL, Edmondson HA(1989) Tumors of the liver and intrahepaticbile ducts. In: Craig JR (ed) Atlas of tumor pathology, 2nd series, fascicle 26. Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  • Davies MH, Harrison RF, Elias E, Hubscher SG(1994) Antibiotic-associated acute vanishing bile duct syndrome: a pattern associated with severc, prolonged, intrahepatic cholestasis. J Hepatol 20:112–116

    Article  PubMed  CAS  Google Scholar 

  • Falk H, Thomas LB, Popper H, Ishak KG(1979) Hepatic angiosarcoma associated with androgenic-anabolic steroids. Lancet 2: 1120–1123

    Article  PubMed  CAS  Google Scholar 

  • Gerber A, Raab AP, Sobel AE(1954) Vitamin A poisoning in adults, with description of a case. Am J Med 16:729

    Article  PubMed  CAS  Google Scholar 

  • Geubel AP, Nakad A, Rahier J, Dive C(1988) Prolonged cholestasis and disappearance of interlobular bile ducts following chlorpropamide and erythromycin ethylsuccinate. Case of drug interaction? Liver 8:350–353

    CAS  Google Scholar 

  • Ishak KG(1982) The liver. In: Riddell RH (ed) Pathology of drug-induced and toxic diseases. Churchill-Livingstone, New York

    Google Scholar 

  • Ishii M, Miyazaki Y, Yamamoto T, Miura M, Ueno Y, Takahashi T, Toyota T(1993) A case of drug-induced ductopenia resulting in fatal biliary cirrhosis. Liver 13:227– 231

    PubMed  CAS  Google Scholar 

  • Ito Y, Kojiro M, Nakashima T, Mori T(1988) Pathomorphologic characteristics of 102 cases of Thorotras-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma. Cancer 62:1153–1162

    Article  PubMed  CAS  Google Scholar 

  • Johnson FL, Feagler JR, Lerner KGet al.(1972) Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet 2:1273– 1276

    Article  PubMed  CAS  Google Scholar 

  • Knowles DM, Casarella WJ, Johnson PM, Wolff M(1978) The clinical, radiologic, and pathologic characterization of benign hepatic neoplasms: alleged association with oral contraceptives. Medicine 57:223–237

    Article  PubMed  Google Scholar 

  • Koch HK, Gropp A, Oehlert W(1985) Drug-induced liver injury in liver biopsies of the years 1981 and 1983, their prevalence and type of presentation. Pathol Res Pract 179:469–477

    PubMed  CAS  Google Scholar 

  • Kowalski TE, Falestiny M, Furth E, Malet PF(1994) Vitamin A hepatotoxicity: a caustionary note regarding 25000 IU supplements. Am J Med 97:523–528

    Article  PubMed  CAS  Google Scholar 

  • Kunelis CT, Peters JL, Edmondson HA(1965) Fatty liver of pregnancy and its relationship to tetracycline toxicity. Am J Med 38:359–377

    Article  PubMed  CAS  Google Scholar 

  • Ladaga L, Kay S, Melcher M, King JN(1979) Combined epithelial and sarcomatous elements in a liver cancer associated with oral contraceptive use. Am J Surg Pathol 3:185–190

    Article  PubMed  CAS  Google Scholar 

  • Lalonde G, Theoret G, Daloze Pet al.(1982) Inferior vena cava stenosis and Budd- Chiari syndrome in a woman taking oral contraceptives. Gastroenterology 82:1452–1456

    PubMed  CAS  Google Scholar 

  • Lander JJ, Stanley RJ, Sumner HW, Boswell DC, Aach RD(1975) Angiosarcoma of the liver associated with Fowler’s solution (potassium arsenite). Gastroenterology 68:1582–1586

    PubMed  CAS  Google Scholar 

  • Licht H, Seiff LB, Zimmerman HJ(1980) Apparent potentiation of acetaminophen hepatotoxicity by alcohol. Ann Intern Med 92:511

    PubMed  CAS  Google Scholar 

  • Littlewood E, Barrison I, Murray-Lyon IM, Paradinas FJ(1980) Cholangiocarcinoma and oral contraceptives. Lancet 1 :310–311

    Article  PubMed  CAS  Google Scholar 

  • Loomus GN, Aneja P, Bota RA(1983) A case of peliosis hepatis in association with tamoxifen therapy. Am J Clin Pathol 80:881–882

    PubMed  CAS  Google Scholar 

  • Ludwig J, Axelsen R(1983) Drug effects on the liver: an updated tabular compilation of drugs and drug-related hepatic diseases. Dig Dis Sci 28:651–666

    Article  PubMed  CAS  Google Scholar 

  • Manivel JC, Bloomer JR, Snover DC(1987) Progressive bile duct injury after thiabendazole administration. Gastroenterology 93:245–249

    PubMed  CAS  Google Scholar 

  • McMaster KR III, Hennigar GR(1981) Drug-induced granulomatous hepatitis. Lab Invest 44:61–73

    PubMed  Google Scholar 

  • Morris JS, Schmid M, Newman S, Scheuer PJ, Sherlock S(1974) Arsenic and noncirrhotic portal hypertension. Gastroenterology 66:86–94

    PubMed  CAS  Google Scholar 

  • Mulvihill J, Ridolfi R, Schultz F, Borzy MS, Haughton PBT(1975) Hepatic adenoma in fanconi anemia treated with oxymetholone. J Pediatr 87:122–124

    Article  PubMed  CAS  Google Scholar 

  • Nadell J, Kosek J(1977) Peliosis hepatis. Twelve cases associated with oral androgen therapy. Arch Pathol Lab Med 101 :405–410

    PubMed  CAS  Google Scholar 

  • Paradinas FJ, Bull TB, Westaby D, Murry-Lyon IM(1977) Hyperplasia and prolapse of hepatocytes into hepatic veins during longterm methyltestosterone therapy: possible relationships of these changes to the development of peliosis hepatis and liver tumours. Histopathology 1:225–246

    Article  PubMed  CAS  Google Scholar 

  • Powell EE, Cooksley WGE, Hanson R, Searle J, Halliday JW, Powell LW(1990) The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11:74–80

    Article  PubMed  Google Scholar 

  • Ransohoff DF, Jacobs G(1981) Terminal hepatic failure following a small dose of sulfamethoxazole-trimethoprim. Gastroenterology 80:816–819

    PubMed  CAS  Google Scholar 

  • Rex D, Lumeng L, Eble J, Rex L(1983) Intrahepatic cholestasis and sicca complex after thiabendazole: report of a case and review of the literature. Gastroenterology 85:718–721

    PubMed  CAS  Google Scholar 

  • Seeff LB(1981) Drug-induced chronic liver disease, with emphasis on chronic active hepatitis. Semin Liver Dis 1:104–115

    Article  PubMed  CAS  Google Scholar 

  • Shulman HM, McDonald GB, Mathews D (1980) An analysis of hepatic veno-occlusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology 79:1178–1l91

    PubMed  CAS  Google Scholar 

  • Sippel PJ, Agger WA(1981) Nitrofurantoin-induced granulomatous hepatitis. Urology 18:177–178

    Article  PubMed  CAS  Google Scholar 

  • Stricker BHC(1992) Drug-induced hepatic injury, 2nd edn. Elsevier Science, Amsterdam

    Google Scholar 

  • Stricker BH, Van der Broek JW, Keuning J et al. (1989) Cholestatic hepatitis due to antibacterial combination of amoxicillin and clavulanic acid (augmentin). Dig Dis Sci 34:1576–1580

    Article  PubMed  CAS  Google Scholar 

  • Stromeyer FW, Smith DH, Ishak KG(1979) Anabolic steroid therapy and intrahepatic cholangiocarcinoma. Cancer 43:440–443

    Article  PubMed  CAS  Google Scholar 

  • Thomas LB, Popper H, Berk PD, Selikoff I, Falk H(1975) Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti’s syndrome) to angiosarcomas. N Engl J Med 292:17–22

    CAS  Google Scholar 

  • Thomas LB, Popper H, Berk PD, Selikoff L Falk H, Koch HK, Gropp A. Oehlert W (1985) Drug-induced liver injury in liver biopsies of the years 1981 and 1983, their prevalence and type of presentation. Pathol Res Pract 179:469–477

    Google Scholar 

  • Valla D, Benhamou JP(1988) Liver diseases related to oral contraceptives. Dig Dis 6:76–86

    Article  PubMed  CAS  Google Scholar 

  • Verhamme M, Ramboer C, Van deBruaene P, Inderadjaja N(1989) Cholestatic hepatitis due to amoxycillin/clavulanic acid preparation. J Hepatol 9:260–264

    Article  PubMed  CAS  Google Scholar 

  • Weston CF, Cooper BT, Davies JD, Levine DF(1987) Veno-occlusive disease of the liver secondary to ingestion of comfrey. Br Med 1 295: 183

    Article  Google Scholar 

  • Whitcomb DC, Block GD(1994) Association of acetaminophen hepatotoxicity with fasting and ethanol use. JAMA 272:1845–1850

    Article  PubMed  CAS  Google Scholar 

  • Woolf GM, Vierling JM(1993) Disappearing intrahepatic bile ducts: the syndromes and their mechanisms. Semin Liver Dis 13:261–275

    Article  PubMed  CAS  Google Scholar 

  • Zafrani ES, Pinaudeau Y, Dhumeaux D(1983) Drug-induced vascular lesions of the liver. Arch Intern Med 143:495–502

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman HJ(1978) Hepatotoxicity. Appleton-Century-Crofts, New York

    Google Scholar 

  • Zimmerman HJ(1981) Effects of aspirin and acetaminophen on the liver. Arch Intern Med 141:333–342

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. D. C. Snover
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pathology Division of Experimental Pathology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, M5S 1A8, Toronto, Ontario, Canada

    Ross G. Cameron M.D., Ph.D.

  2. Department of Clinical Biochemistry Banting Institute, University of Toronto, Room 521, 100 College Street, M5G 1L5, Toronto, Ontario, Canada

    George Feuer Ph.D.

  3. Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental Toxicology, Warner Lambert Company, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Felix A. de la Iglesia M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Snover, D.C. (1996). Diagnostic Tools and Clinical Pathology. In: Cameron, R.G., Feuer, G., de la Iglesia, F.A. (eds) Drug-Induced Hepatotoxicity. Handbook of Experimental Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61013-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-61013-4_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64657-7

  • Online ISBN: 978-3-642-61013-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation