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Spontaneous Knockout of CSF-1 Gene in the Mouse as a Model to Study the Organization of the Macrophage System

  • Conference paper
Gene Technology

Part of the book series: NATO ASI Series ((ASIH,volume 94))

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Abstract

Physiological role of many molecules and cells can be investigated by evaluating animals possessing genetically determined alterations in the production of those molecules and/or cells. While animals with either knockouts of genes for various molecules or transgenic for these molecules could be at present experimentally created, there is still not fully explored potential of natural mutants, the so called “experiments of nature”(Good, 1991). In particular, there are several natural mutants with osteopetrosis: a disorder of osteoclasts i e cells related to macrophages, and they all may have alterations in other parts of the macrophage system (Wiktor-Jedrzejczak et al. , 1981, Marks 1987).

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Authors and Affiliations

  1. Department of Immunology, Central Clinical Hospital, Military School of Medicine, PL00-909, Warsaw, Poland

    Wieslaw Wiktor-Jedrzejczak & Andrzej Nowicki

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  1. Wieslaw Wiktor-Jedrzejczak
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  2. Andrzej Nowicki
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Editors and Affiliations

  1. Universitätskrankenhaus Eppendorf, Martinistraße 52, D-20246, Hamburg, Germany

    Axel R. Zander

  2. Heinrich-Pette-lnstitut für Experimentelle Virologie und Immunologie, Universität Hamburg, Martinistraße 52, D-20246, Hamburg, Germany

    Wolfram Ostertag

  3. City Center for Advanced Medical Technologies, Bone Marrow Transplantation Center, Pr. Dynamo 3, 197042, St.Petersburg, Russia

    Boris V. Afanasiev

  4. Laboratory for Gene Structure Expression, Medical Research Council Institute, The Ridgeway, Mill Hill, London, NW71AA, UK

    Frank Grosveld

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© 1996 Springer-Verlag Berlin Heidelberg

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Wiktor-Jedrzejczak, W., Nowicki, A. (1996). Spontaneous Knockout of CSF-1 Gene in the Mouse as a Model to Study the Organization of the Macrophage System. In: Zander, A.R., Ostertag, W., Afanasiev, B.V., Grosveld, F. (eds) Gene Technology. NATO ASI Series, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61122-3_24

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  • DOI: https://doi.org/10.1007/978-3-642-61122-3_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64704-8

  • Online ISBN: 978-3-642-61122-3

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