Abstract
The tight control of cell proliferation is essential during embryogenesis, development, wound repair and maintenance of tissue structure. These control mechanisms involve the communication of each single cell with its neighbouring cells via interleukins and cytokines. These molecules exert their functions through specific membrane receptors which induce activation of intracellular signalling proteins upon activation by their specific agonists. Disturbance or disruption of this control mechanisms are believed to result in abnormal cell proliferation as observed in various diseases that correlate with proliferative disorders such as hyperdermia, fibrosis, atherosclerosis, glomerulonephritis, and tumorigenesis. Regardless whether the dividing cell is of transformed or non-transformed origin, the basic cellular events triggering cell proliferation are the same.
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Roth, M. (1996). Role of Intracellular Interleukin-6 in Growth Factor-Induced Cell Proliferation. In: Tsiftsoglou, A.S., Sartorelli, A.C., Housman, D.E., Dexter, T.M. (eds) Tumor Biology. NATO ASI Series, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61180-3_25
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DOI: https://doi.org/10.1007/978-3-642-61180-3_25
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