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Purine Arabinosides, Xylosides, and Lyxosides

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Antineoplastic and Immunosuppressive Agents

Abstract

Arabinosyluracil and arabinosylthymine were identified in extracts of the sponge, Crytotethya crypta (Bergmans and Burke, 1955), but arabinosylpurines were first obtained by chemical synthesis (Lee et al., 1960; Reist et al., 1962). Eventually one of these, arabinosyladenine, was found as an antibiotic in cultures of Streptomyces antibioticus (Parke-Davis and Company, 1967). A considerable number of arabinosylpurines have now been obtained, some with interesting biological properties. Their chemistry and a range of biological tests have received detailed discussion (Cohen, 1966; Suhadolnik, 1970). This discussion will be limited to those having most relevance to tumor and virus studies, and particularly to those on which an appreciable volume of data has accumulated. The structures of relevant arabinosylpurines are shown in Fig. 1.

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Authors
  1. G. A. LePage
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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LePage, G.A. (1975). Purine Arabinosides, Xylosides, and Lyxosides. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_20

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  • DOI: https://doi.org/10.1007/978-3-642-65806-8_20

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  • Print ISBN: 978-3-642-65808-2

  • Online ISBN: 978-3-642-65806-8

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