Beta-Lipoprotein Entry Into the Arterial Wall and Its Prevention

Abstract

The authors (Shimamoto et al., 1972; Shimamoto and Sunaga, 1972a; Shimamoto and Sunaga, 1972b; Shimamoto and Numano, 1972c; Shimamoto, 1972; Shimamoto, 1973) previously found that the acute entry of β-lipoprotein, fibrinogen and r-globulin is induced into subendothelial and medial layers of the artery directly after a single-dose treatment of rabbits with cholesterol, epinephrine and angiotensin II and it is induced by stimulation of arterial endothelial cells by these challenges. The stimulated endothelial cells show strong contracting and swallowing activities, resulting in entry of relatively large particles with the size up to pre-β-lipoprotein in the subendothelial space, although it is not yet known what active agent is involved in the effect of cholesterol given orally. In this experiment the authors used rhesus monkeys to see whether such a phenomenon exists in this species.