Abstract
Intracranial hypertension and hydrocephalus may produce functional disturbances in the brain which, to a certain extent, are manifested in neurological symptoms. The damage to the brain parenchyma can also be estimated in terms of alterations in certain biochemical parameters, but it is difficult to distinguish to which extent such alterations are associated with the neurons or with other components of the brain. More specifically, the neuronal injury can be studied by morphological approaches, either at the level of optical or electron microscopy. However, it should be born in mind that a neuronal impairment which is demonstrable by morphological techniques, has already reached a fairly advanced stage.
Supported by the Swedish Medical Research Council (grant No. 14X-732).
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References
Björklund, A., Falck, B., Owman, C.: Fluorescence microscopic and microspectrofluorometric techniques for the cellular localization and characterization of biogenic amines. In: Berson, S.A. (ed.): Methods of Investigative and Diagnostic Endocrinology, vol. 1: Rall, J.E., Kopin, I.J. (eds): The Thyroid and Biogenic Amines, pp. 318–368. Amsterdam: North Holland Publ. Co. 1972.
Lindvall, O., Björklund, A.: The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons. Histochemistry 39, 97–127 (1974).
Fuxe, K.: Evidence for the existence of monoamine neurons in the central nervous system. Thesis, Stockholm, pp. 1–35. Uppsala: Almqvist and Wiksell 1965.
Ungerstedt, U.: Stereotaxic mapping of the monoamine pathways in the rat brain. Acta physiol. scand., suppl. 367 (1971).
Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta physiol. scand., suppl. 412 (1974).
Owman, C., West, K.A.: Effect of superior cervical sympathectomy on experimentally induced intracranial hypertension. Brain Res. 18, 469–476 (1970).
Edvinsson, L., Nielsen, K.C., Owman, C., West, K.A.: Alterations in intracranial pressure, blood-brain barrier, and brain edema after sub-chronic implantation of a cannula into the brain of conscious animals. Acta physiol. scand. 82, 527–531 (1971).
Edvinsson, L., West, K.A.: The time-course of intracranial hypertension as recorded in conscious rabbits after treatment with different amounts of intracisternally injected kaolin. Acta neurol. scand. 47, 439–450 (1971).
Edvinsson, L., West, K.A.: Relation between intracranial pressure and ventricular size at various stages of experimental hydrocephalus. Acta neurol. scand. 47, 451–457 (1971).
Bertler, A.: Occurrence and localization of catechol amines in the human brain. Acta physiol. scand. 51, 97–107 (1961).
Bertler, A., Carlsson, A., Rosengren, E., Waldeck, B.: A method for the fluorimetric determination of adrenaline, nor-adrenaline, and dopamine in tissues. Kungl. Fysiogr. Sällsk. Lund Förh. 28, 121–123 (1958).
Andén, N.E., Roos, B.-E., Werdinius, B.: On the occurrence of homovanillic acid in brain cerebrospinal fluid and its de-dermination by a fluorimetric method. Life Sci. 2, 448–458 (1963).
Häggendal, J.: An improved method for fluorimetric determination of small amounts of adrenaline and noradrenaline in plasma and tissues. Acta physiol. scand. 59, 242–254 (1963).
Edvinsson, L., Owman, C., Rosengren, E., West, K.A.: Brain concentrations of dopamine, noradrenaline, 5-hydroxytryptamine, and homovanillic acid during intracranial hypertension following traumatic brain injury in rabbit. Acta neurol. scand. 47, 458–463 (1971).
Hochwald, G.M., Sahar, A., Sadik, A.R., Ransohoff, J.: Cerebrospinal fluid production and histological observations in animals with experimental obstructive hydrocephalus. Exp. Neurol. 25, 190–199 (1969).
Hakim, S., Adams, R.D.: The special clinical problem of symptomatic hydrocephalus with normal cerebrospinal fluid pressure. Observations on cerebrospinal fluid hydrodynamics. J. Neurol. Sci. 2, 307–327 (1965).
Owman, C., Rosengren, E., West, K.A.; Influence of various intracranial pressure levels on the concentration of certain arylethylamines in rabbit brain. Experientia 27, 1036–1037 (1971).
Edvinsson, L., Nielsen, K.C., Owman, C., Rosengren, E., West, K.A.: Concomitant fall in brain dopamine and homovanillic acid in hydrocephalic rabbits. Exp. Neurol. 37, 647–649 (1972).
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Owman, C., Edvinsson, L., Rosengren, E., Svendgaard, N., West, K.A. (1975). Effects of Intracranial Hypertension, Low-Pressure Hydrocephalus and Subsequent Ventriculo-Peritoneal Shunting on Monoamine Neurons in Rabbit Brain. In: Lundberg, N., Pontén, U., Brock, M. (eds) Intracranial Pressure II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66086-3_38
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DOI: https://doi.org/10.1007/978-3-642-66086-3_38
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