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Humoral Factors Abrogating Cell-Mediated Immunity in the Tumor-Bearing Host

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 72))

Abstract

The concept that tumor-specific immune responses may effectively control or even suppress tumor growth has developed from studies showing that immunity can be induced against many, although by no means all, experimentally induced animal tumors when transplanted into syngeneic hosts (Hellström and Hellström, 1969b; Sjögren, 1965; Baldwin, 1973). This was originally established in tests with animal tumors, either induced by chemical carcinogens or oncogenic viruses, or arising spontaneously, showing that syngeneic hosts preimmunized against tumor, e.g., by implantation of radiation-attenuated tumor cells, rejected a subsequent challenge graft of the same tumor. Following this, it was found in a number of instances that animals with a transplanted tumor developing at one site and which is beyond host control can, nevertheless, reject a concomitant challenge with the same tumor implanted at another site, providing that the challenge inoculum is not too great (Gershon et al., 1967; Vaage, 1971; Deckers et al., 1973; Chandradasa, 1973). This indicates that the tumor-bearing host has developed an effective immune response to tumor implanted at a second site and implies that either the response was too weak or developed too slowly to cause rejection of the primary tumor implant, or that, alternatively, host factor(s) may have modified the initial tumor-immune response.

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References

  • Baldwin, R. W.: Immunological aspects of chemical carcinogenesis. Advanc. Cancer Res. 18, 1–75 (1973)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Embleton, M. J.: Demonstration by colony inhibition methods of cellular and humoral immune reactions to tumour-specific antigens associated with aminoazo dye-induced rat hepatomas. Internat. J. Cancer 7, 17–25 (1971)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Embleton, M. J.: Neoantigens on spontaneous and carcinogen-induced rat tumours defined by in vitro lymphocytotoxicity assays. Internat. J. Cancer 13, 433–443 (1974)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Pimm, M. V.: BCG immunotherapy of a rat sarcoma. Brit. J. Cancer 28, 281–287 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Price, M. R.: Neoantigen expression in chemical carcinogenesis. In: Cancer: A Comprehensive Treatise, Vol. I. Becker, F. F. (ed.). New York: Plenum Press. In press 1975

    Google Scholar 

  • Baldwin, R. W., Vose, B. M.: Embryonic antigen expression on 2-acetyl-aminofluorene-induced and spontaneously arising rat tumours. Brit. J. Cancer 30, 209–214 (1974a)

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Vose, B. M.: The expression of a phase-specific foetal antigen on rat embryo cells. Transplantation 18, 525–530 (1974b)

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Bowen, J. G., Price, M. R.: Detection of circulating hepatoma D23 antigen and immune complexes in tumour-bearer serum. Brit. J. Cancer 28, 16–24 (1973 a)

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Embleton, M. J., Moore, M.: Immunogenicity of rat hepatoma membrane fractions. Brit. J. Cancer 28, 389–399 (1973b)

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Embleton, M. J., Price, M. R., Vose, B. M.: Embryonic antigen expression on experimental rat tumours. Transplant. Rev. 20, 77–99 (1974a)

    PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Embleton, M. J., Robins, R. A.: Cellular and humoral immunity to rat hepatoma-specific antigens correlated with tumour status. Internat. J. Cancer 11, 1–10 (1973c)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Glaves, D., Vose, B. M.: Embryonic antigen expression in chemically induced rat tumours. Internat. J. Cancer 10, 233–243 (1972a)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Glaves, D., Vose, B. M.: Differentiation between embryonic and tumour specific antigens on chemically-induced tumours. Brit. J. Cancer 29, 1–10 (1974b)

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, R. W., Harris, J. R., Price, M. R.: Fractionation of plasma membrane-associated tumour-specific antigen from an aminoazo dyeinduced rat hepatoma. Internat. J. Cancer 11, 385–397 (1973d)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Price, M. R., Robins, R. A.: Blocking of lymphocyte cytotoxicity for rat hepatoma cells by tumour-specific antigen-antibody complexes. Nature (Lond.) New Biol. 238, 185–187 (1972b)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Price, M. R., Robins, R. A.: Significance of serum factors modifying cellular immune responses to growing tumours. Brit. J. Cancer 28, Suppl. I, 37–47 (1973e)

    Google Scholar 

  • Baldwin, R. W., Price, M. R., Robins, R. A.: Inhibition of hepatomaimmune lymph node cell cytotoxicity by tumour-bearer serum and solubilized hepatoma antigen. Internat. J. Cancer 11, 527–535 (1973f)

    Article  CAS  Google Scholar 

  • Baldwin, R. W., Price, M. R., Vose, B. M.: Fetal antigen expression on chemically induced tumours and their relationship to α-fetoprotein. In: Proc. Internat. Conf. on Alpha-feto-protein. Masseyeff, R. (ed.), p. 181–189. Paris: INSERM, 1974c

    Google Scholar 

  • Bansal, S. C., Sjögren, H. O.: Unblocking serum activity in vitro in the polyoma system may correlate with antitumour effects of antiserum in vivo. Nature (Lond.) New Biol. 233, 76–77 (1971)

    CAS  Google Scholar 

  • Bansal, S. C., Sjögren, H. O.: Counteraction of the blocking of cellmediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats. Internat. J. Cancer 9, 490–509 (1972)

    Article  CAS  Google Scholar 

  • Bansal, S. C., Sjögren, H. O.: Regression of polyoma tumor metastasis by combined unblocking and BCG treatment—correlation with induced alterations in tumor immunity status. Internat. J. Cancer 12, 179–193 (1973)

    Article  CAS  Google Scholar 

  • Bansal, S. C., Hargreaves, R., Sjögren, H. O.: Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate. Internat. J. Cancer 9, 97–108 (1972)

    Article  CAS  Google Scholar 

  • Basham, C., Currie, G. A.: Development of specific cell-dependent antibody during growth of a syngeneic rat sarcoma. Brit. J. Cancer 29, 189–198 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Belehradek, J., Barski, G., Thonier, M.: Evolution of cell mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells. Internat. J. Cancer 9, 461–469 (1972)

    Article  Google Scholar 

  • Berke, G., Sullivan, K. A.: Temperature control of lymphocyte-mediated cytotoxicity in vitro. Transplant. Proc. 5, 421–423 (1973)

    PubMed  CAS  Google Scholar 

  • Blair, P. B., Lane, M. A.: Serum factors in mammary neeplasia: enhancement and antagonism of spleen cell activity in vitro detected by different methods of serum factor assay. J. Immunol. 112, 439–443 (1974)

    PubMed  CAS  Google Scholar 

  • Blair, P. B., Lane, M. A., Yagi, M. J.: Blocking of spleen cell activity against target mammary tumor cells by viral antigens. J. Immunol. 115, 190–194 (1975)

    PubMed  CAS  Google Scholar 

  • Blasecki, J. W., Tevethia, S. S.: In vitro studies on the cellular immune response of tumor-bearing mice to SV40-transformed cells. J. Immunol. 114, 244–249 (1975)

    PubMed  CAS  Google Scholar 

  • Bowen, J. G.: Tumour antigen in human cancer patients’ sera. Brit. J. Cancer. 32, 242 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Bowen, J. G., Baldwin, R. W.: Serum factor levels during pulmonary growth of transplanted rat hepatoma D23. To be published (1975)

    Google Scholar 

  • Bowen, J. G., Robins, R. A., Baldwin, R. W.: Serum factors modifying cell mediated immunity to rat hepatoma D23 correlated with tumour growth. Internat. J. Cancer 15, 640–650 (1975)

    Article  CAS  Google Scholar 

  • Bray, A. E., Holt, P. G., Roberts, L. M., Keast, D.: Early onset of serum blocking in a murine melanoma model. Internat. J. Cancer. In press (1975)

    Google Scholar 

  • Burk, M. W., Yu, S., Ristow, S. S., McKhann, C. F.: Refractoriness of lymph node cells from tumour-bearing animals. Internat. J. Cancer 15, 99–108 (1975)

    Article  CAS  Google Scholar 

  • Chandradasa, K. D.: The development of specific suppression of concomitant immunity in two syngeneic tumour-host systems. Internat. J. Cancer 11, 648–662 (1973)

    Article  CAS  Google Scholar 

  • Coggin, J. H., Anderson, N. G.: Cancer, differentiation and embryonic antigens: some central problems. Advanc. Cancer Res. 19, 106–165 (1974)

    Google Scholar 

  • Currie, G. A., Basham, C.: Serum-mediated inhibition of the immunological reactions of the patient to his own tumour: a possible role for circulating antigen. Brit. J. Cancer 26, 427–438 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Currie, G. A., McElwain, T. J.: Active immunotherapy as an adjunct to chemotherapy in the treatment of disseminated malignant melanoma: a pilot study. Brit. J. Cancer 31, 143–156 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Dauphinee, M. J., Taxal, M., Witz, I. P.: Generation of non-complement-fixing blocking factors by lysosomal extract treatment of cytotoxic anti-tumor antibodies. J. Immunol. 113, 948–953 (1974)

    PubMed  CAS  Google Scholar 

  • Deckers, P. J., Davis, R. C., Parker, G. A., Mannick, J. A.: The effect of tumor size on concomitant tumor immunity. Cancer Res. 33, 33–39 (1973)

    PubMed  CAS  Google Scholar 

  • Eilber, F. R., Morton, D. L.: Immunologic response to human sarcomas: relation of antitumor antibody to the clinical course. In: Progress in Immunology. Vol. I (ed. B. Amos), p. 951–957. New York: Academic Press 1971

    Google Scholar 

  • El Ridi, R., Bubeník, J.: Tumour-associated antigen in the serum of rats with large Rous sarcoma virus-induced tumours. Folia Biol. 19, 273–280 (1973)

    Google Scholar 

  • El Ridi, R., Bubeník, J.: Tumour associated transplantation antigen in sera of rats with large RSV-induced sarcomas. Int. J. Cancer 16, 83–90 (1975)

    Article  PubMed  Google Scholar 

  • Faanes, R. B., Choi, Y. S., Good, R. A.: Escape from isoantiserum inhibition of lymphocyte-mediated cytotoxicity. J. Exp. Med. 137, 171–182 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Faanes, R. B., Choi, Y. S.: Interaction of isoantibody and cytotoxic lymphocytes with allogeneic tumor cells. J. Immunol. 113, 279–288 (1974)

    PubMed  CAS  Google Scholar 

  • Forni, G., Comoglio, P. M.: Effect of solubilized membrane antigens and tumour bearer serum on tumour growth in syngeneic hosts. Brit. J. Cancer 30, 365–369 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Fujimoto, S., Chen, C. H., Sabbadini, E., Sehon, A. H.: Association of tumor and histocompatibility antigens in sera of lymphoma-bearing mice. J. Immunol. 111, 1093–1100 (1973)

    PubMed  CAS  Google Scholar 

  • Fujimoto, S., Greene, M. I., Sehon, A. H.: Regulation of the immune response to tumor antigens. I. Immunosuppressor T cells in tumor bearing hosts. J. Immunol. In press (1975a)

    Google Scholar 

  • Fujimoto, S., Greene, M. I., Sehon, A. H.: Regulation of the immune response to tumor antigens. II. The nature of immunosuppressor T cells in tumor bearing hosts. J. Immunol. In press (1975b)

    Google Scholar 

  • Gershon, R. K., Carter, R. L., Kondo, K.: On concomitant immunity in tumour-bearing hamsters. Nature (Lond.) 213, 674–676 (1967)

    Article  CAS  Google Scholar 

  • Golub, S. H., Morton, D. L.: Sensitization of lymphocytes in vitro against human melanoma-associated antigens. Nature (Lond.) 251, 161–163 (1974)

    Article  CAS  Google Scholar 

  • Gorczynski, R. M., Knight, R. A.: Immunity to murine sarcoma virus induced tumors. Direct cellular cytolysis of 51Cr-labelled target cells in vitro and analysis of blocking factors which modulate cytotoxicity. Internat. J. Cancer. Submitted for publication (1975)

    Google Scholar 

  • Gorczynski, R. M., Kilburn, D. G., Knight, R. A., Norbury, C., Parker, D. C., Smith, J.B.: Nonspecific and specific immunosuppression in tumour-bearing mice by soluble immune complexes. Nature (Lond.) 254, 141–143 (1975)

    Article  CAS  Google Scholar 

  • Gupta, R. K., Morton, D. L.: Suggestive evidence for in vivo binding of specific antitumor antibodies in human melanomas. Cancer Res. 35, 58–62 (1975)

    PubMed  CAS  Google Scholar 

  • Halliday, W. J.: Macrophage migration inhibition with mouse tumor antigens: properties of serum and peritoneal cells during tumor growth and after tumor loss. Cell. Immunol. 3, 113–122 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Halliday, W. J., Maluish, A., Miller, S.: Blocking and unblocking of cell-mediated anti-tumor immunity in mice as detected by the leucocyte adherence inhibition test. Cell. Immunol. 10, 467–475 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hayami, M., Hellström, I., Hellström, K. E.: Serum effects on cell-mediated destruction of Rous sarcomas. Internat. J. Cancer 12, 667–688 (1973)

    Article  CAS  Google Scholar 

  • Hayami, M., Hellström, I., Hellström, K. E., Lannin, D. R.: Further studies on the ability of regressor sera to block cell-mediated destruction of Rous sarcomas. Int. J. Cancer 13, 43–53 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Hellström, I., Hellström, K. E.: Studies on cellular immunity and its serum mediated inhibition in Moloney-virus-induced mouse sarcomas. Int. J. Cancer 4, 587–600 (1969 a)

    Article  PubMed  Google Scholar 

  • Hellström, I., Hellström, K. E.: Colony inhibition studies on blocking and non-blocking serum effects on cellular immunity to Moloney sarcomas. Int. J. Cancer 5, 195–201 (1970a)

    Article  PubMed  Google Scholar 

  • Hellström, I., Hellström, K. E., Sjögren, H. O.: Serum-mediated inhibition of cellular immunity to methylcholanthrene-induced murine sarcomas. Cell. Immunol. 1, 18–30 (1970b)

    Article  PubMed  Google Scholar 

  • Hellström, I., Hellström, K. E.: Cell-mediated immune reactions to tumor antigens with particular emphasis on immunity to human neoplasms. Cancer (Phila.) 34, 1461–1468 (1974a)

    Article  Google Scholar 

  • Hellström, I., Hellström, K.E.: Cytotoxic effect of lymphocytes from pregnant mice on cultivated tumor cells. I. Specificity, nature of effector cells and blocking by serum. Internat. J. Cancer 15, 1–16 (1975a)

    Article  Google Scholar 

  • Hellström, I., Hellström, K. E.: Cytotoxic effects of lymphocytes from pregnant mice on cultivated tumor cells. II. Blocking and unblocking of cytotoxicity. Internat. J. Cancer 15, 30–38 (1975b)

    Article  Google Scholar 

  • Hellström, I., Hellström, K. E., Pierce, G. E., Fefer, A.: Studies on immunity to autochthonous mouse tumors. Transplant. Proc. 1, 90–94 (1969)

    PubMed  Google Scholar 

  • Hellström, I., Hellström, K. E., Sjögren, H. O., Warner, G. A.: Serum factors in tumor-free patients cancelling the blocking of cell mediated tumor immunity. Int. J. Cancer 8, 185–191 (1971)

    Article  PubMed  Google Scholar 

  • Hellström, I., Warner, G. A., Hellström, K. E., Sjögren, H. O.: Sequential studies on cell-mediated tumor immunity and blocking serum activity in ten patients with malignant melanoma. Int. J. Cancer 11, 280–292 (1973)

    Article  PubMed  Google Scholar 

  • Hellström, K. E.: Discussion. In: Schering Symposium on Immunopathology. Advanc. Biosciences 12, 551 (1974)

    Google Scholar 

  • Hellström, K. E., Hellström, I.: Cellular immunity against tumor antigens. Advanc. Cancer Res. 12, 167–223 (1969b)

    Article  Google Scholar 

  • Hellström, K. E., Hellström, I.: Immunological enhancement as studied by cell culture techniques. Ann. Rev. Microbiol. 24, 373–398 (1970b)

    Article  Google Scholar 

  • Hellström, K. E., Hellström, I.: Lymphocyte-mediated cytotoxicity and serum activity to tumor antigens. Advanc. Immunol. 18, 209–277 (1974b)

    Article  Google Scholar 

  • Henderson, W. R., Fukuyama, K., Epstein, W. L., Spitler, L. E.: Blocking of a cellular immune reaction to malignant melanoma by immunoglobulin from tumor-bearing animals. J. Reticuloend. Soc. 13, 155–160 (1973)

    CAS  Google Scholar 

  • Heppner, G. H.: In vitro studies on cell-mediated immunity following surgery in mice sensitized to syngeneic mammary tumors. Internat. J. Cancer 9, 119–125 (1972)

    Article  CAS  Google Scholar 

  • Howell, S. B., Dean, J. H., Law, L. W.: Defects in cell-mediated immunity during growth of syngeneic simian virus-induced tumor. Internat. J. Cancer 15, 152–169 (1975)

    Article  CAS  Google Scholar 

  • Jose, D. G., Seshadri, R.: Circulating immune complexes in human neuroblastoma. Direct assay and role in blocking specific cellular immunity. Internat. J. Cancer 13, 824–838 (1974)

    Article  CAS  Google Scholar 

  • Kirchner, H., Muchmore, A. V., Chused, T. M., Holden, H. T., Herberman, R. B.: Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice. J. Immunol. 114, 206–210 (1975)

    PubMed  CAS  Google Scholar 

  • Knight, R. A., Gorczynski, R. M.: Cell mediated immunity to Moloney sarcoma virus in mice. I. Analysis of antigens responsible for lymphocyte stimulation in regressor mice. Internat. J. Cancer 15, 48–58 (1975)

    Article  CAS  Google Scholar 

  • Knight, R. A., Mitchison, N. A., Shellam, G. R.: Studies on a Gross-virusinduced lymphoma in the rat. II. The role of cell membrane-associated and serum p30 antigen in the antibody and cell-mediated response. Internat. J. Cancer 15, 417–428 (1975)

    Article  CAS  Google Scholar 

  • Kolb, J. P., Poupon, M. F., Lespinats, G.: Tumor-associated antigen (TAA) and anti-TAA antibodies in the serum of BALB/c mice with plasmacytomas. J. Nat. Cancer Inst. 52, 723–727 (1974)

    PubMed  CAS  Google Scholar 

  • Lane, M. A., Roubinian, J., Slomich, M., Trefts, P., Blair, P. B.: Characterization of cytotoxic effector cells in the mouse mammary tumor system. J. Immunol. 114, 24–29 (1975)

    PubMed  CAS  Google Scholar 

  • Laux, D., Lausch, R. N.: Reversal of tumor-mediated suppression of immune reactivity by in vitro incubation of spleen cells. J. Immunol. 112, 1900–1908 (1974)

    PubMed  CAS  Google Scholar 

  • Le François, D., Youn, J. K., Belehradek, J., Barski, G.: Evolution of cell mediated immunity in mice bearing tumors produced by a mammary carcinoma cell line. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells. J. Nat. Cancer Inst. 46, 981–987 (1971)

    PubMed  Google Scholar 

  • Leonard, E. J.: Cell surface antigen movement: induction in hepatoma cells by antitumor antibody. J. Immunol. 110, 1167–1169 (1973)

    Google Scholar 

  • Martin-Chandon, M. R., Vanky, F., Carnaud, C., Klein, E.: In vitro ‘education’ on autologous human sarcoma generates non-specific killer cells. Internat. J. Cancer 15, 342–350 (1975)

    Article  CAS  Google Scholar 

  • Mikulska, Z. B., Smith, C, Alexander, P.: Evidence for an immunological reaction of the host directed against its own actively growing primary tumor. J. Nat. Cancer Inst. 36, 29–35 (1960)

    Google Scholar 

  • Mukojima, T., Gunvén, P., Klein, G.: Circulating antigen-antibody complex associated with Epstein-Barr virus in recurrent Burkitt’s lymphoma. J. Nat. Cancer Inst. 51, 1319–1322 (1973)

    PubMed  CAS  Google Scholar 

  • Nelson, K., Pollack, S. B., Hellström, K. E.: Specific anti-tumor responses by cultured immune spleen cells. I. In vitro culture method and initial characterization of factors which block immune cell mediated cytotoxicity in vitro. Internat. J. Cancer 15, 806–814 (1975)

    Article  CAS  Google Scholar 

  • Nind, A. P. P., Matthews, N., Pihl, E. A. V., Rolland, J. M., Nairn, R. C.: Analysis of inhibition of lymphocyte cytotoxicity in human colon carcinoma. Brit. J. Cancer 31, 620–629(1975)

    Article  PubMed  CAS  Google Scholar 

  • Noonan, P. F., Gardner, M. A. H., Clunie, G. J. A., Isbister, W. H., Halliday, W. J.: Control of tumor growth in mice by thoracic duct drainage: relationship to blocking factor in lymph. Internat. J. Cancer 13, 640–649 (1974)

    Article  CAS  Google Scholar 

  • Old, L. J., Boyse, E. A.: Immunology of experimental tumors. Ann. Rev. Med. 15, 167–186 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Paranjpe, M. S., Boone, C. W.: Kinetics of the anti-tumor delayed hypersensitivity response in mice with progressively growing tumors: stimulation followed by specific suppression. Internat. J. Cancer 13, 179–186 (1974)

    Article  CAS  Google Scholar 

  • Perlmann, P., Wigzell, H., Golstein, P., Lamon, E. W., Larsson, A., O’Toole, C., Perlmann, H., Svedmyr, E. A. J.: Cell mediated cytolysis in vitro: analysis of active lymphocyte subpopulations in different experimental systems. Ad vane. Biosciences 12, 71–85 (1974)

    Google Scholar 

  • Phillips, T. M., Lewis, M. G.: A method for elution of immunoglobulin from the surface of living cells. Rev. Europ. études Clin. Biol. 16, 1052–1053 (1971)

    CAS  Google Scholar 

  • Plata, F., Levy, J. P.: Blocking of syngeneic effector T cells by soluble tumour antigens. Nature (Lond.) 249, 271–274 (1974)

    Article  CAS  Google Scholar 

  • Pollack, S.: Specific ‘arming’ of normal lymph-node cells by sera from tumor-bearing mice. Internat. J. Cancer 11, 138–142 (1973)

    Article  CAS  Google Scholar 

  • Pollack, S., Heppner, G. H., Brawn, R. J., Nelson, K.: Specific killing of tumor cells in vitro in the presence of normal lymphoid cells and sera from hosts immune to the tumor antigen. Internat. J. Cancer 9, 316–323 (1972)

    Article  CAS  Google Scholar 

  • Poupon, M.-F., Lespinats, G., Kolb, I.P.: Blocking effect of the migration-inhibition reaction by sera from immunized syngeneic mice and by sera from plasmacytoma-bearing BALB/c mice. Detection of free, circulating tumor antigen. J. Nat. Cancer Inst. 52, 1127–114 (1974)

    PubMed  CAS  Google Scholar 

  • Proctor, J. W., Rudenstam, C. M., Alexander, P.: A factor preventing development of lung metastases in rats with sarcomas. Nature (Lond.) 242, 29–31 (1973)

    Article  CAS  Google Scholar 

  • Ran, M., Witz, I. P.: Tumor-associated immunoglobulins. The elution of IgG2 from mouse tumors. Internat. J. Cancer 6, 361–372 (1970)

    Article  CAS  Google Scholar 

  • Ran, M., Witz, I.P.: Tumor-associated immunoglobulins: Enhancement of syngeneic tumors by IgG2-containing tumor eluates. Internat. J. Cancer 9, 242–247 (1972)

    Article  CAS  Google Scholar 

  • Rees, R. C., Price, M. R., Baldwin, R. W., Shah, L. P.: Inhibition of rat lymph node cell cytotoxicity by hepatoma-associated embryonic antigen. Nature (Lond.) 252, 751–753 (1974)

    Article  CAS  Google Scholar 

  • Rees, R. C., Price, M. R., Shah, L. P., Baldwin, R. W.: Detection of hepatoma-associated embryonic antigen in tumour-bearer serum. Transplantation 19, 424–429 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Robins, R. A.: Serum antibody responses to an ascitic variant of rat hepatoma D23. Brit. J. Cancer 32, 21–27 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Robins, R. A., Baldwin, R. W.: Tumour-specific antibody neutralization of factors in rat hepatoma-bearer serum which abrogate lymph node cell cytotoxicity. Internat. J. Cancer 14, 589–597 (1974)

    Article  CAS  Google Scholar 

  • Ruoslahti, E., Pihko, H., Seppälä, M.: Alpha-fetoprotein: immunochemical purification and chemical properties. Expression in normal state and in malignant and non-malignant liver disease. Transplant. Rev. 20, 38–60 (1974)

    PubMed  CAS  Google Scholar 

  • Sharma, B., Terasaki, P. I.: In vitro immunization to cultured human tumor cells. Cancer Res. 34, 115–118 (1974)

    PubMed  CAS  Google Scholar 

  • Shellam, G. R.: Studies on a Gross-virus-induced lymphoma in the rat. I. The cell-mediated immune response. Internat. J. Cancer 14, 65–82 (1974)

    Article  CAS  Google Scholar 

  • Shellam, G. R., Knight, R.A.: Antigenic inhibition of cell-mediated cytotoxicity against tumour cells. Nature (Lond.) 252, 330–332 (1974)

    Article  CAS  Google Scholar 

  • Sjögren, H. O.: Transplantation methods as a tool for detection of tumor-specific antigens. Progr. Exp. Tumor Res. 6, 289–322 (1965)

    PubMed  Google Scholar 

  • Sjögren, H. O., Hellström, I., Bansal, S. C., Hellström, K. E.: Suggestive evidence that the “blocking antibodies” of tumor-bearing individuals may be antigen-antibody complexes. Proc. Nat. Acad. Sci. (Wash.) 68, 1372–1375 (1971)

    Article  Google Scholar 

  • Sjögren, H. O., Hellström, I., Bansal, S. C., Warner, G. A., Hellström, K. E.: Elution of blocking factors from human tumors capable of abrogating tumor-cell destruction by specifically immune lymphocytes. Internat. J. Cancer 9, 274–283 (1972)

    Article  Google Scholar 

  • Smith, H. G., Leonard, E. J.: Humoral immune responses to tumor-specific antigens in strain-2 guinea pigs. J. Nat. Cancer Inst. 53, 187–194 (1974)

    PubMed  CAS  Google Scholar 

  • Sobczak, E., De Vaux St Cyr, Ch. H.: Study of the in vivo fixation of antibodies on tumors provoked in hamsters by injection of SV40-transformed cells (TSV5 C12). Internat. J. Cancer 8, 47–52 (1971)

    Article  CAS  Google Scholar 

  • Terry, W. D., Henkart, P. A., Coligan, J. E., Todd, C. W.: Carcinoembryonic antigen: characterization and clinical applications. Transplant. Rev. 20, 100–129 (1974)

    PubMed  CAS  Google Scholar 

  • Thomson, D. M. P.: Soluble tumor-specific antigen and its relationship to tumor growth. Internat. J. Cancer 15, 1016–1029 (1975)

    Article  CAS  Google Scholar 

  • Thomson, D. M. P., Eccles, S., Alexander, P.: Antibodies and soluble tumour-specific antigens in blood and lymph of rats with chemically induced sarcomata. Brit. J. Cancer 28, 6–15 (1973a)

    Article  PubMed  CAS  Google Scholar 

  • Thomson, D. M. P., Sellens, V., Eccles, S., Alexander, P.: Radioimmunoassy of tumour specific transplantation antigen of a chemically induced rat sarcoma: circulating soluble tumour antigen in tumour bearers. Brit. J. Cancer 28, 377–388 (1973b)

    Article  PubMed  CAS  Google Scholar 

  • Thunold, S., Tönder, O., Larsen, O.: Immunoglobulins in eluates of malignant human tumors. Acta pat. microbiol. Scand. Suppl. 236, 97–100 (1973)

    CAS  Google Scholar 

  • Todd, R. F., Stulting, R. D., Berke, G.: Mechanism of blocking by hyperimmune serum of lymphocyte-mediated cytolysis of allogeneic tumor cells. Cancer Res. 33, 3203–3208 (1973)

    PubMed  Google Scholar 

  • Todd, R. F., Stulting, R. D., Berke, G.: Mechanism of inhibition of lymphocyte-mediated cytolysis by blocking antiserum. In: Proc. 8th Leucocyte Culture Conf. (eds. K. Lindahl-Kiessling, D. Osoba), p. 379–384. New York: Academic Press 1974

    Google Scholar 

  • Vaage, J.: Concomitant immunity and specific depression of immunity by residual or reinjected syngeneic tumor tissue. Cancer Res. 31, 1655–1662 (1971)

    PubMed  CAS  Google Scholar 

  • Vaage, J.: Specific desensitization of resistance against a syngeneic methylcholanthrene-induced sarcoma in C3Hf mice. Cancer Res. 32, 193–199 (1972)

    PubMed  CAS  Google Scholar 

  • Vaage, J.: Influence of tumor antigen on maintenance versus depression of tumor specific immunity. Cancer Res. 33, 493–503 (1973)

    PubMed  CAS  Google Scholar 

  • Vaage, J.: Circulating tumor antigens versus immune serum factors in depressing concomitant immunity. Cancer Res. 34, 2979–2983 (1974)

    PubMed  CAS  Google Scholar 

  • Vanky, F., Stjernswärd, J., Klein, G., Steiner, L., Lindberg, L.: Tumor-associated specificity of serum-mediated inhibition of lymphocyte stimulation by autochthonous human tumors. J. Nat. Cancer Inst. 51, 25–32 (1974)

    Google Scholar 

  • Vasudevan, D. M., Brunner, K. T., Cerottini, J.-C.: Detection of cytotoxic T lymphocytes in the EL4 mouse leukemia system: increased activity of immune spleen and peritoneal cells following preincubation and cell fractionation procedures. Internat. J. Cancer 14, 301–313 (1974)

    Article  CAS  Google Scholar 

  • Whitney, R. B., Levy, J. G., Smith, A. G.: Influence of tumor size and surgical resection on cell-mediated immunity in mice. J. Nat. Cancer Inst. 53, 111–116 (1974)

    PubMed  CAS  Google Scholar 

  • Witz, I. P.: The biological significance of tumor-bound immunoglobulins. Curr. Topics Microbiol. Immunol. 61, 151–171 (1973)

    CAS  Google Scholar 

  • Witz, I. P., Yagi, Y., Pressman, D.: IgG associated with microsomes from autochthonous hepatomas and normal liver of rats. Cancer Res. 27, 2295–2299 (1967)

    PubMed  CAS  Google Scholar 

  • Youn, J. K., Le François, D., Barski, G.: In vitro studies on mechanism of the “eclipse” of cell-mediated immunity in mice bearing advanced tumors. J. Nat. Cancer Inst. 50, 921–926 (1973)

    PubMed  CAS  Google Scholar 

  • Zöller, M., Price, M. R., Baldwin, R. W.: Cell-mediated cytotoxicity to chemically-induced rat tumours. Internat. J. Cancer 16, 593–606 (1975a)

    Article  Google Scholar 

  • Zöller, M., Price, M. R., Baldwin, R. W.: Inhibition of rat tumour-bearer and tumour-immune lymph node cell cytotoxicity by soluble tumour and embryo cell extracts. To be published (1975b)

    Google Scholar 

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Authors and Affiliations

  1. Cancer Research Campaign Laboratories, University of Nottingham, Nottingham, England

    R. W. Baldwin & R. A. Robins

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  1. R. W. Baldwin
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  2. R. A. Robins
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Editors and Affiliations

  1. Basle, Switzerland

    W. Arber  & N. K. Jerne  & 

  2. Philadelphia, USA

    W. Henle , P. Koldovský  & H. Koprowski ,  & 

  3. Martinsried, Germany

    P. H. Hofschneider

  4. London, UK

    J. H. Humphrey

  5. Copenhagen, Denmark

    O. Maaløe

  6. Gießen, Germany

    R. Rott

  7. Wilhelmshaven, Germany

    H. G. Schweiger

  8. Rehovot, Israel

    M. Sela

  9. Prague, Czech Republic

    L. Syruček

  10. Los Angeles, USA

    P. K. Vogt

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© 1975 Springer-Verlag Berlin · Heidelberg

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Baldwin, R.W., Robins, R.A. (1975). Humoral Factors Abrogating Cell-Mediated Immunity in the Tumor-Bearing Host. In: Arber, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 72. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66289-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-66289-8_2

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