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The Role of Monoamines in the Development of Cold-Induced Edema

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Dynamics of Brain Edema

Summary

Our results show that even the experimentally induced high concentrations of exogenous 5-HT in the brain tissue during the early phase of edema formation are not able to increase the amount of fluid accumulation in the normal and injured brain tissue. The changes of the endogenous 5-HT levels in the blood and the brain tissue result in similar hemispheric water and RISA differences between the injured and uninjured half of the brain. Moreover, 5-HT concentrations elevated by 100% failed to produce detectable edema in the normal brain tissue of the rat.

We believe, therefore, that our data are convincing enough to change the focus of future 5-HT studies from the site of the blood-brain barrier and the dynamic process of edema formation to the neuronal cell and its functional disturbances after brain injury.

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Authors and Affiliations

  1. Departments of Neurology, University of Mainz, Mainz, W. Germany

    A. Fenske, K. Sinterhauf & H. J. Reulen

  2. Departments of Internal Medicine, University of Mainz, Mainz, W. Germany

    A. Fenske, K. Sinterhauf & H. J. Reulen

  3. Departments of Neurosurgery, University of Mainz, Mainz, W. Germany

    A. Fenske, K. Sinterhauf & H. J. Reulen

Authors
  1. A. Fenske
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  2. K. Sinterhauf
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  3. H. J. Reulen
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Editor information

Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Fenske, A., Sinterhauf, K., Reulen, H.J. (1976). The Role of Monoamines in the Development of Cold-Induced Edema. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_25

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  • DOI: https://doi.org/10.1007/978-3-642-66524-0_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08009-1

  • Online ISBN: 978-3-642-66524-0

  • eBook Packages: Springer Book Archive

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