Abstract
The observation that calcium stones of renal origin may be associated with uric acid disorders has been made on many occasions. Prien and Prien (1968) noted that patients with gout, who also suffered from stones, frequently passed stones which contained, or were composed of, calcium oxalate. Gutman (1968) also mentioned the surprisingly high frequency of calcium oxalate stones in gout patients and called attention to crystallographic studies of Lonsdale (1968 a, b) showing a significant enough structural correspondence between crystals of uric acid, sodium hydrogen urate, and calcium oxalate to allow one to grow upon the surface of another or to act for one another as heterogeneous seed nuclei. Dent and Sutor (1971), in a study examining inhibitors of calcium oxalate crystal growth in urine from normal people and patients with recurrent calcium oxalate renal stones, found that stone formers were more often hyperuricemic than normals, even though none of the patients had clinical gout. Smith and his colleagues (1969) have made similar observations and have suggested that calcium stone formers with uric acid disorders represent a significant metabolic subgroup of calcium stone disease.
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References
Bridges, M.A., Mattice, M.R.: Food and Beverage Analyses. Philadelphia: Lea and Febiger 1942
Coe, F. L., Kavalich, A.G.: Hypercalciuria and hyperuricosuria in patients with calcium nephrolithiasis. New Engl. J. Med. 291, 1344–1350 (1974)
Coe, F.L., Lawton, R.L., Goldstein, R.B., Tembe, V.: Sodium urate accelerates precipitation of calcium oxalate in vitro. Proc. Soc. exp. Biol. (N.Y.) 149, 926–929 (1975)
Coe, F.L., Raisen, L.: Allopurinol treatment of uric-acid disorders in calcium-stone formers. Lancet 1973 I, 129–131
Dent, E.D., Sutor, D.J.: Presence or absence of inhibitor of Calciumoxalate crystal growth in urine of normals and of stone formers. Lancet 1971 I, 776–778
Edwards, B.R., Baer, P.G., Sutton, R.A.L., Dirks, J.H.: Micropuncture study of diuretic effects on sodium and calcium reabsorption in the dog nephron. J. clin. Invest. 52, 2418–2427 (1973)
Emerson, B.T., Graham-Row, P.: Pathogenesis of the gouty kidney. Kidney Int. 8, 65–71 (1975)
Fleisch, H., Bisaz, S.: Isolation from urine of pyrophosphate, a calcification inhibitor. Amer. J. Physiol. 203, 671–675 (1962)
Gutman, A.B.: Uric acid nephrolithiasis. Amer. J. Med. 45, 756–779 (1968)
Gutman, A.B., Yü, T.F.: Renal function in gout, with a commentary on the renal regulation of urate excretion, and the role of the kidneys in the pathogenesis of gout. Amer. J. Med. 23, 600–625 (1957)
Kavalich, A. G., Moran, E., Coe, F.L.: Dietary purine consumption by hyperuricosuric calcium oxalate kidney stone formers and normal subjects. J. chron. Dis. 29, 745–760 (1976)
Lonsdale, K.: Human stones. Science 159, 1159–1207 (1968 a)
Lonsdale, K.: Epitaxy as a growth factor in urinary calculi and gallstones. Nature (Lond.) 217, 56–58 (1968 b)
Meyer, J.L., Smith, L.H.: Growth of calcium oxalate crystals. Inhibition by natural crystal growth inhibitors. Invest. Urol. 13, 36–39 (1975)
Pak, C.Y.C.: Personal communication 1976
Pak, C.Y.C., Arnold, L.H.: Heterogeneous nucleation of calcium oxalate by seeds of monosodium urate. Proc. Soc. exp. Biol. (N.Y.) 149, 930–932 (1975)
Pak, C.Y.C., Holt, K.: Nucleation and growth of brushite and calcium oxalate in urine of stone formers. Metabolism 25, 665–673 (1976)
Pak, C.Y.C., Waters, O., Ornold, L., Holt, K., Cox, C., Barilla, D.: Mechanism for calcium urolithiasis among patients with hyperuricosuria: supersaturation of urine with respect to mono-sodium urate. J. clin. Invest. (1977) (in press)
Prien, E.L., Prien, E. L., Jr.: Composition and structure of urinary stone. Amer. J. Med. 45, 654–672 (1968)
Robertson, W.G.: Physical chemical aspects of calcium stone formation in the urinary tract. In: Fleisch, H., Robertson, W.G., Smith, L.H., Vahlensieck, W. (Eds.): Urolithiasis Research, pp. 25–40. London: Plenum Press 1976
Robertson, W.G., Knowles, F., Peacock, M.: Urinary acid mucopolysaccharide inhibitors of calcium oxalate crystallization. In: Fleisch, H., Robertson, W.G., Smith, L.H., Vahlensieck, W. (Eds.): Urolithiasis Research, pp. 331–334. London: Plenum Press 1976
Robertson, W.G., Marshall, R. W., Peacock, M., Knowles, F.: The saturation of urine in recurrent, idiopathic calcium stone formers. In: Fleisch, H., Robertson, W.G., Smith, L.H., Vahlensieck, W. (Eds.): Urolithiasis Research, pp. 335–338. London: Plenum Press 1976
Smith, M.J.V.: Placebo vs. Allopurinol for renal calculi. J. Urol. (1977) (in press)
Smith, M.J.V., Hunt, L.D., King, J.S., Jr., Boyce, W.H.: Uricemia and urolithiasis. J. Urol. 101, 637–642 (1969)
Steele, T. H., Rieselbach, R. E.: The renal mechanism for urate homeostasis in normal man. Amer. J. Med. 43, 868–875 (1967)
Uhlman, D.R.: Crystal growth from solutions. Interface structure and interface kinetics. In: Finlayson, B. et al. (Ed.): Urolithiasis-Physical Aspects, pp. 169–176. Washington, D.C.: Nat. Acad. Sci. 1972
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Coe, F.L. (1987). Association of Calcium Nephrolithiasis with Disorders of Uric Acid Metabolism. In: Kelley, W.N., Weiner, I.M. (eds) Uric Acid. Handbook of Experimental Pharmacology, vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66867-8_18
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DOI: https://doi.org/10.1007/978-3-642-66867-8_18
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