Abstract
The role of intestinal metaplasia as a precursor of the intestinal type of gastric cancer has received support from multiple fronts. Bonne and collaborators reported in 1938 that Chinese immigrants to Java had a high frequency of gastric cancer and high prevalence of “goblet-cell metaplasia” while both lesions were rare in the local natives [1]. Jarvi and Lauren in 1951 reported that the majority of gastric cancers originated in islands of intestinal epithelium [10]. Morson in 1955 documented the origin of small gastric carcinomas in areas of metaplasia [12]. Similar findings were reported in Japan by Nagayo [14]. Metaplasia has been induced with carcinogens in experimental animals [5, 11]. Studies of internal migration in Colombia have shown positive correlation between the prevalence of metaplasia in autopsies and the incidence of carcinoma [2]. Metaplasia is more frequent in Japan than in the United States [9]. Patients with metaplasia have about ten times greater risk of carcinoma than people with negative gastric biopsies [13].
Work supported by contracts NO1-CP-53521 and NO1-CP-33286
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References
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Cuello, C., Correa, P. (1979). Dysplastic Changes in Intestinal Metaplasia of the Gastric Mucosa. In: Herfarth, C.H., Schlag, P.M. (eds) Gastric Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67368-9_12
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DOI: https://doi.org/10.1007/978-3-642-67368-9_12
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