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Evalution of Adrenergic Alpha- and Beta-Receptor Activators and Adrenergic Alpha- and Beta-Receptor Blocking Agents

  • Chapter
Adrenergic Activators and Inhibitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 54 / 1))

Abstract

The proper evaluation of adrenergic drugs is important not only in understanding the theoretical aspects of adrenoceptors, but also in the utilization of these substances in therapeutics. Currently, chemicals are being synthesized for organ receptor specificity. Since absolute specificity is practically impossible, investigators look for relative selectivity. Occasionally, judgment regarding organ specificity may be based on few- fold differences between the activity of a drug in different tissues. To arrive at such a conclusion, a critical evaluation of drugs is important. Hence, evaluation from the point of view of quantitation and the factors which affect quanitation is emphasized.

Studies of the authors discussed in this chapter were supported by grants from the United States Public Health Service, The National Institute of Health, grant numbers GM-17859, NS- 10896, NS-09350 and HL-12215.

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  1. R. R. Ruffolo Jr.

    Present address: Eli Lilly and Co., Indianapolis, Indiana, USA

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    1. P. N. Patil
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    2. R. R. Ruffolo Jr.
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    1. Institute of Pharmacology, University Medical School of Szeged, Dóm tér 12, H-6701, Szeged, Hungary

      Lászlo Szekeres

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    Patil, P.N., Ruffolo, R.R. (1980). Evalution of Adrenergic Alpha- and Beta-Receptor Activators and Adrenergic Alpha- and Beta-Receptor Blocking Agents. In: Szekeres, L. (eds) Adrenergic Activators and Inhibitors. Handbook of Experimental Pharmacology, vol 54 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67505-8_3

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