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Biochemical Pharmacology of Psychotomimetics

  • Chapter
Psychotropic Agents

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 55 / 3))

Abstract

The long and recently accelerated search for mechanisms of actions of drugs with psychotomimetic effects has utilized a broad array of classic pharmacologic and structure activity approaches (Cerletti and Doepfner, 1958; Hofmann, 1968), as well as quantitative structure activity relationships linked to molecular and submolecular properties (Barnett, et al., 1978). Behavioral and psychopharmacologic studies in man (Hollister, 1968; Freedman, 1968) and animal (Appel, 1968; Cameron and Appel, 1973; Jacobs et al., 1977) have appeared. Also utilized have been the techniques of neurophysiology (Brawley and Duffield, 1972; Aghajanian and Wang, 1978; Jacobs and Trulson, 1979); and biochemical pharmacology (Giarman and Freedman, 1965; Brimblecombe, 1973; Freedman and Halaris, 1978) as applied to CNS neurons. Central to this research has been a focus on d-lysergic acid diethylamide (LSD) because of the specificity, high potency, and reliability with which the drug produces a time-limited period of altered mental functioning. Approximately a billionth of a gram of LSD per gram of brain produces a 10-h state in which there is a compelled enhanced attention to subjective experience, a vividness of perception and affectivity (which is labile), and a diminished control over attention to environmental input (to which there is an enhanced but variably sustained reactivity).

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Authors
  1. D. X. Freedman
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  2. W. O. Boggan
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Editors and Affiliations

  1. Institut für Pharmakologie, Bayer AG, Aprather Weg 18a, D-5600, Wuppertal 1, Germany

    F. Hoffmeister

  2. Institut für Arzneimittel des Bundesgesundheitsamtes, Stauffenbergstraße 13, D-1000, Berlin 30, Germany

    G. Stille

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© 1982 Springer-Verlag Berlin Heidelberg

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Freedman, D.X., Boggan, W.O. (1982). Biochemical Pharmacology of Psychotomimetics. In: Hoffmeister, F., Stille, G. (eds) Psychotropic Agents. Handbook of Experimental Pharmacology, vol 55 / 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67770-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-67770-0_4

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