Skip to main content
SpringerLink
Log in

Elektrophysiologie von Tocainid

  • Conference paper
Ventrikuläre Herzrhythmusstörungen

Zusammenfassung

Tocainid (2-amino-2′,6′-propionoxilidid HCl) ist ein neues lidocainähnliches Antiarrhythmikum. Im Gegensatz zum Lidocain besitzt es jedoch aufgrund seiner primären Aminstruktur eine niedrige hepatische Clearance, hohe systemische Bioverfügbarkeit sowie eine lange Halbwertszeit. Diese pharmakokinetischen Charakteristika bestimmen seine orale Wirksamkeit [25].

Mit Unterstützung der Deutschen Forschungsgemeinschaft

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Anderson JL, Mason JW, Winkle RA, Meffin PJ, Fowles RE, Peters F, Harrison DC (1978) Clinical elektrophysiologic effects of tocainide. Circulation 57:685

    PubMed  CAS  Google Scholar 

  2. Arita N, Nagamoto Y, Saikawa T (1976) Automaticity and time-dependent conduction disturbances produced in canine ventricular myocardium. New aspects for initiation of ventricular arrhythmias. Jpn Circ J 40:1409

    Article  PubMed  CAS  Google Scholar 

  3. Arnsdorf MF, Bigger JT (1972) Effect of lidocaine hydrochloride on membrane conductance in mammalian cardiac Purkinje fibers. J Clin Invest 51:2252

    Article  PubMed  CAS  Google Scholar 

  4. Bigger JT, Mandel WJ (1970) Effect of lidocaine on the electrophysiological properties of ventricular muscle and Purkinje fibers. J Clin Invest 49:63

    Article  PubMed  CAS  Google Scholar 

  5. Cardinal R, Janse MJ, Eeden IV, Werner G, Naumann d’Alnoncourt C, Durrer D (to be published) The effects of lidocaine on intracellular and extracellular potentials, activation and ventricular arrhythmias during acute myocardial ischemia in the isolated porcine heart. Circ Res

    Google Scholar 

  6. Chen CM, Gettes LS, Katzung BG (1975) Effects of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium. Circ Res 37:20

    PubMed  CAS  Google Scholar 

  7. Coltart DJ, Berndt TB, Kernoff R, Harrison DC (1974) Antiarrhythmic and circulatory effects of Astra W 36095. A new lidocaine-like agent. Am J Cardiol 34:35

    Article  PubMed  CAS  Google Scholar 

  8. Engler R, Ryan W, LeWinter M, Bluestein H, Karliner JS (1979) Assessment of long-term antiarrhythmic therapy: Studies on the long-term efficacy and toxicity of tocainide. Am J Cardiol 43:612

    Article  PubMed  CAS  Google Scholar 

  9. Harrison DC, Meffin PJ, Winkle RA (1978) Clinical pharmacology and antiarrhythmic actions of tocainide. Br Heart J 40[Suppl]:83

    Google Scholar 

  10. Imanishi S, Surawicz B (1976) Automatic activity in depolarized guinea pig ventricular myocardium. Characteristics and mechanisms. Circ Res 39:751

    PubMed  CAS  Google Scholar 

  11. Janse MJ, Capelle FJL van, Morsink H, Kléber AG, Wilms-Schopman F, Cardinal R, Naumann d’Alnoncourt C, Durrer D (1980) Flow of injury current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Evidence for two different arrhythmogenic mechanisms. Circ Res 47:151

    PubMed  CAS  Google Scholar 

  12. Katzung BG, Morgenstern JA (1977) Effects of extracellular potassium on ventricular automaticity and evidence for a pacemaker current in mammalian ventricular myocardium. Circ Res 40:105

    PubMed  CAS  Google Scholar 

  13. Kléber AG, Janse MJ, Capelle FJL van, Durrer D (1978) Mechanism and time course of S-T and T-Q segment changes during acute regional myocardial ischemia in the pig’s heart determined by extracellular and intracellular recordings. Circ Res 42:603

    PubMed  Google Scholar 

  14. Lüderitz B, Naumann d’Alnoncourt C (1980) Herzrhythmusstörungen bei Myokardinfarkt. Internist 21:652

    PubMed  Google Scholar 

  15. Mandel WJ, Bigger JT (1971) Electrophysiologic effects of lidocaine on isolated canine and rabbit a trial tissue. J Pharmacol Exp Ther 178:81

    PubMed  CAS  Google Scholar 

  16. McDevitt DG, Nies AS, Wilkinson GR, Smith RF, Woosley RL, Oates JA (1976) Antiarrhythmic effects of a lidocaine congener, tocainide, 2-amino-2′, 6′-propionoxylidide, in man. Clin Pharmacol Ther 19:396

    PubMed  CAS  Google Scholar 

  17. Moore EN, Spear JF, Horowitz LN, Feldman HS, Moller RA (1978) Electrophysiologic properties of a new antiarrhythmic drug — tocainide. Am J Cardiol 41:703

    Article  PubMed  CAS  Google Scholar 

  18. Naumann d’Alnoncourt C, Cardinal R, Janse MJ, Lüderitz B, Durrer D (1980) Effects of tocainide on ectopic impulse formation in isolated cardiac tissue. Klin Wochenschr 58:227

    Article  PubMed  Google Scholar 

  19. Naumann d’Alnoncourt C, Cardinal R, Janse MJ (1981) Über die arrhythmogene Wirkung von Potentialdifferenzen im Ventrikelmyokard. Dieses Buch S 70

    Google Scholar 

  20. Ryan WF, Karliner JS (1979) Effects of tocainide on left ventricular performance at rest and during acute alterations in heart rate and systematic arterial pressure. Br Heart J 41:175

    Article  PubMed  CAS  Google Scholar 

  21. Vaughan Williams EM (1973) Development of new antiarrhythmic drugs. Schweiz Med Wochenschr 103:262

    CAS  Google Scholar 

  22. Waleffe A, Bruninx P, Rabine LM, Kulbertus HE (1979) Effects of tocainide studied with programmed electrical stimulation of the heart in patients with reentrant tachyarrhythmias. Am J Cardiol 43:292

    Article  PubMed  CAS  Google Scholar 

  23. Winkle RA, Meffin PJ, Harrison DC (1978) Long-term tocainide therapy for ventricular arrhythmias. Circulation 57:1008

    PubMed  CAS  Google Scholar 

  24. Woosley RL, McDevitt DG, Nies AS, Smith RF, Wilkinson GR, Oates JA (1977) Suppression of ventricular ectopic depolarizations by tocainide. Circulation 56:980

    PubMed  CAS  Google Scholar 

  25. Woosley RL, Shand DG (1978) Pharmacokinetics of antiarrhythmic drugs. Am J Cardiol 41:986

    Article  PubMed  CAS  Google Scholar 

  26. Zipes DP, Troup PJ (1978) New Antiarrhythmic Agents. Amiodarone, aprindine, disopyramide, ethmozin, mexiletine, tocainide, verapamil. Am J Cardiol 41:1005

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Klinik I der Universität, Klinikum Großhadern, Marchioninistraße 15, D-8000, München 70, Deutschland

    Dr. C. Naumann d’Alnoncourt & Prof. Dr. B. Lüderitz

Authors
  1. Dr. C. Naumann d’Alnoncourt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. B. Lüderitz
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik I der Universität München, Klinikum Großhadern, Marchioninistraße 15, D-8000, München 70, Deutschland

    Berndt Lüderitz

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

d’Alnoncourt, C.N., Lüderitz, B. (1981). Elektrophysiologie von Tocainid. In: Lüderitz, B. (eds) Ventrikuläre Herzrhythmusstörungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67951-3_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67951-3_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67952-0

  • Online ISBN: 978-3-642-67951-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation