Abstract
The basic pharmacological property of nitrites is to relax smooth muscle, and the well-documented hemodynamic effects of these drugs have generally been thought to be secondary to their actions on vascular smooth muscle [5, 11]. Direct cardiac effects have remained largely undetermined or controversial. We have studied the actions of nitroglycerin (NTG) on left ventricular (LV) function in man administered by the sublingual (SL) [1] route and by intracoronary (IC) injection [6]. This approach allowed separation of direct (cardiac) and indirect (peripheral) effects of the drug.
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References
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Amende, I., Simon, R., Hood, W.P., Daniel, W., Lichtlen, P. (1981). Direct and Indirect Effects of Nitroglycerin on Systolic and Diastolic Left Ventricular Function. In: Lichtlen, P.R., Engel, HJ., Schrey, A., Swan, H.J.C. (eds) Nitrates III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68085-4_19
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DOI: https://doi.org/10.1007/978-3-642-68085-4_19
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