Zusammenfassung
Beim Mammakarzinom gilt heute von den Steroid-Hormonrezeptoren vor allem die Bestimmung der Östrogen-Rezeptoren als klinisch etablierte Methode [5, 6, 10, 15, 16]. Grundsätzlich dient der Hormonrezeptor-Nachweis zur Unterscheidung von hormonabhängigen und hormonunabhängigen Geweben. Die Bedeutung der Hormonrezeptoren zeigt sich durch folgende Beziehungen und prognostische Aussagemöglichkeiten (Rezeptor-Bestimmung als biochemischer „Prediction-Test“):
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1.
Hormonrezeptoren dienen zur Entscheidung des Einsatzes einer Hormontherapie beim fernmetastasierenden Mammakarzinom.
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2.
Hormonrezeptoren sind prognostische Faktoren beim primären Mammakarzinom.
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3.
Es besteht eine Korrelation von Hormonrezeptoren und histopathologischen Befunden und es
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4.
besteht beim Mammakarzinom eine Korrelation zur Proliferationsrate in vitro (Thymidin-Labeling-Index, Chemosensibilitäts-Kurzzeittest).
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Kaufmann, M., Klinga, K., Runnebaum, B., Kubli, F. (1984). Die klinische Bedeutung von Steroid-Hormonrezeptoren beim Mammakarzinom. In: Kubli, F., von Fournier, F. (eds) Neue Konzepte der Diagnostik und Therapie des Mammakarzinoms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68088-5_34
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