Abstract
T cells recognize antigen and self MHC products simultaneously. This phenomenon of H-2 restriction was discovered some eight years ago, but it is still not understood sufficiently (1,2). The outstanding problems appear to be the following: Do T cells have one or two receptors? Is their ligand a complex or two unconnected determinants on separate molecules? Studies with T cell hybrid clones allow one to investigate the first question by means of somatic genetics: Gene complementation between the fusion partners can reveal whether dual specificity is controlled by one or by more loci.
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Lonai, P., Arman, E., Bitton-Grossfeld, S., Grooten, J., Hämmerling, G. (1982). H-2-Restricted Helper Hybridomas: One Locus or Two Control Dual Specificity?. In: Boehmer, H.V., Haas, W., Köhler, G., Melchers, F., Zeuthen, J. (eds) T Cell Hybridomas. Current Topics in Microbiology and Immunology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68586-6_11
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DOI: https://doi.org/10.1007/978-3-642-68586-6_11
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