Abstract
Flexible horny layers have evolved to allow complex muscle movements, increased sensation and intricate manipulations. Flexibility requires horny cells devoid or organelles, but toughened in their plasma membranes and keratinised to fulfil the protective function. Organelles are removed late in epidermal cell (keratinocyte) life at the granular layer stage of differentiation [2]. This process is termed orthokeratosis.
I would like to thank Wolfson College (University of Cambridge) and Brocades (U.K.) Ltd., for their support of this work
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References
Braun-Falco O (1956) Beitrag zum histochemischen Nachweis von Esterasen in normaler und psoriatischer Haut. Arch Klin Exp Derm 202: 153–162
Braun-Falco O (1958) The histochemistry of psoriasis. Ann. NY Acad Sci 73: 936–976
Didierjean L, Wrench R, Saurat J-H (to be published) Expression of cytoplasmic antigens linked to orthokeratosis during the development of parakeratosis in newborn mouse tail epidermis. Differentiation
Jarrett A, Spearman RIC (1964) Histochemistry of the skin-psoriases. Eng University Press, London
LeVine MJ, McGilvray N, Baden HP (1980) Effect of therapy on keratin polypeptide profiles of psoriatic epidermis. Arch Derm 116: 1028–1030
Saurat J-H, Didierjean L, Beucher F, Gluckmann E (1978) Immunofluorescent tracing of cytoplasmic components involved in keratinocyte differentiation. Br J Derm 98: 155–163
Saurat J-H, Didierjean L, Habibi B (1981a) Pr antigens in the skin: distinct localization linked to the stage and the type of keratinocyte differentiation. Br J Derm 105: 25–31
Saurat J-H, Didierjean L, Pavlovitch JH, Laouari D, Balsan S (1981b) Skin calcium binding protein is localized in the cytoplasm of the basal layer of the epidermis. J Invest Derm 76: 221–223
Schweizer J, Marks F (1977) A developmental study of the distribution and frequency of Langerhans cells in relation to formation of patterning in mouse tail epidermis. J Invest Derm 66: 198–204
Spearman RIC (1964) The evolution of mammalian keratinized structures In: Ebling J (ed) The mammalian epidermis and its derivatives. Symposium of the Zoological Society of London 12: 67–81. London: Academic Press, London, pp 67–81
Sporn MB, Newton DL (1979) Chemoprevention of Cancer with Retinoids. Fed Proc 38: 2528–2534
Wilkinson DI (1978) Effect of vitamin A acid on the growth of keratinocytes in culture. Arch Derm Forsch 263: 75–81
Wrench R (1980a) Dendritic cell migrations involving the pilosebaceous unit in the development of murine skin. Zool J Linnean Soc 70: 19–53
Wrench R (1980b) Epidermal thinning: evaluation of commerieal corticosteroids. Arch Dermatol Res 267: 7–24
Wrench R (1981) Scale prophylaxis — A new antiparakeratotic assay. Arch Derm 117: 213–215
Wrench R, Britten AZ (1975a) Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test. Part I: High and low temperature tars and their constituents. Br JDerm 92: 569–574
Wrench R, Britten, AZ (1975b) Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test. Part III: High boiling tar oil acids. Br J Derm 93: 67–74
Wrench R, Didierjean L, Saurat J-H (in preparation (a)). Antibodies to orthokeratotic keratocytes in monitoring the drug — induced inhibition of parakeratotic differentiation in adult and infant mice
Wrench R, Didierjean L, Saurat J-H (in preparation (b)). Redistribution of keratocyte differentiation antigens following retinyl-acetate-induced orthokeratosis
Yaar M, Stanley JR, Katz SI (1981) Retinoic acid delays the terminal differentiation of keratinocytes in suspension culture. J Invest Derm 76: 363–366
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© 1983 Springer-Verlag Berlin Heidelberg
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Wrench, R., Didierjean, L., Saurat, JH. (1983). Drug-Induced Changes in Stratum Corneum Production Traced by Human Antibodies in Murine Tails. In: Marks, R., Plewig, G. (eds) Stratum Corneum. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68682-5_31
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DOI: https://doi.org/10.1007/978-3-642-68682-5_31
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