Abstract
Hepatic release of inorganic fluoride during halothane anaesthesia has been shown to indicate a reductive metabolic pathway resulting in the formation of other, potentially hepatotoxic halothane metabolites [Widger et al. 1976]. This knowledge is mainly based on experimental studies and obviously raises the question: “Does hepatic reductive halothane metabolism occur during clinical halothane anaesthesia in man”?
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Gelman SJ (1976) Disturbances in hepatic blood flow during anesthesia and surgery. Arch Surg 111: 881
Görnandt L, Kessler M (1973) P02 histograms in regenerating liver tissue. In: Kessler M, Bruley DF, Clark LC, Lübbers DW, Silver JA, Strauss J (eds) Oxygen in tissue. Urban amp; Schwarzenberg, Munchen Berlin Wien, p 288
Hughes RL, Cambell D, Fitch W (1980) Effects of enflurane and halothane on liver blood flow and oxygen consumption in the greyhound. Br J Anaesth 52: 1079
Irestedt L (1978) Haemodynamics and oxygen consumption during halothane, enflurane and neurolept anaesthesia. An experimental study in the dog with special reference to the liver and preportal tissues. Thesis, Karolinska institute, Stockholm
Irestedt L, Andreen M (1978) The effect of enzyme induction on hepatic oxygenation during enflurane anesthesia in the dog (Abstract). In: V European congress of anaesthesiology. Excerpta Medica, Amsterdam Princeton London Geneva New York (International congress series No. 452 )
Widger LA, Gandolfi AJ, Van Dyke RA (1976) Hypoxia and halothane metabolism in vivo: Release of inorganic fluoride and halothane metabolite binding to cellular constituents. Anaesthesiology 44: 197
Young SR, Stoelting RK, Peterson C, Madura JA (1975) Anesthetic biotransformation and renal function in obese patients during and after methoxyflurane or halothane anesthesia. Anesthesiology 42: 451
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Irestedt, L. (1982). Hepatic Oxygenation and Fluoride Release During Halothane Anesthesia. In: Peter, K., Jesch, F. (eds) Inhalation Anaesthesia Today and Tomorrow. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 150. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68713-6_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-68713-6_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11757-5
Online ISBN: 978-3-642-68713-6
eBook Packages: Springer Book Archive