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Nebenwirkungen und Interaktionen mit anderen Pharmaka

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Therapie mit Herzglykosiden

Zusammenfassung

Bei Verdacht auf eine tödliche Intoxikation gibt die postmortale Analyse von Serum- und Gewebsproben auf Digitalisglykoside Aufschluß über eine Vergiftung. Insbesondere ist bei älteren Patienten eine tödlich verlaufende Digitalisintoxikation ohne den direkten postmortalen Nachweis im Herzmuskel und Serum nur schwer zu eruieren, da ein großer Teil der Vergiftungen unter der Diagnose „Herz-Kreislaufversagen“ unbekannt bleibt.

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Literatur

  1. Alken RG, Schnabel T, Krüger CJ, Baier M (1980) Retinal effects of digoxin in man. Naunyn Schmiedebergs Arch Pharmacol 313: R59

    Google Scholar 

  2. Anschütz F, Demers HG, Pabst J (1981) Cholestyraminbehandlung einer schweren Digitoxin-vergiftung. In: Kochsiek K, Rietbrock N (Hrsg) Digitalistherapie bei Herzinsuffizienz. Urban & Schwarzenberg, München Wien Baltimore S 159–162

    Google Scholar 

  3. Arnim T von, Krawietz W, Vogt W, Erdmann E (1980) Is the determination of serum digoxin concentration useful for the diagnosis of digitalis toxicity? Int J Clin Pharmacol Ther Toxicol 18: 261–268

    Google Scholar 

  4. Baligadoo S, Chiche P (1981) Frequency of toxicity of digitoxin and factors predisposing to to-xicity in ambulatory patients: A multifactorial correspondence analysis of 2120 outpatients. In: Kochsiek K, Rietbrock N (Hrsg) Digitalistherapie bei Herzinsuffizienz. Urban & Schwarzen-berg, München Wien Baltimore, S 118–126

    Google Scholar 

  5. Baum GL, Dick MM, Blum A, Kaupe A, Carballo J (1959) Factors involved in digitalis sensiti-vity in chronic pulmonary insufficiency. Am Heart J 57: 460–462

    Article  PubMed  CAS  Google Scholar 

  6. Becker DJ, Nonkin PM, Bennet LD, Kimball SG, Sternberg MS, Wassermann F (1962) Effect of isoproterenol in digitalis cardiotoxicity. Am J Cardiol 10: 242–247

    Article  PubMed  CAS  Google Scholar 

  7. Beller GA, Smith TW, Abelmann WH, Haber E, Hood WB (1971) Digitalis intoxication. A pro-spective clinical study with serum level correlations. N Engl J Med 284: 989–997

    Article  PubMed  CAS  Google Scholar 

  8. Beller GA, Smith TW (1973) Digitalis intoxication and serum levels: An epidemiologic study. In: Storstein O (ed) Symposium on Digitalis. Gyldendal Norsk Forlag, Oslo, pp 287–300

    Google Scholar 

  9. Belz GG, Aust PE, Munkes R (1981) Digoxin plasma concentrations and nifedipine. Lancet I: 844–845

    Google Scholar 

  10. Bigger JT, Strauss HC (1972) Digitalis toxicity: Drug interactions promoting toxicity and the management of toxicity. Semin Drug Treat 2: 147–177

    PubMed  CAS  Google Scholar 

  11. Brown DD, Juhl RP (1976) Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N Engl J Med 295: 1034–1037

    Article  PubMed  CAS  Google Scholar 

  12. Brown DD, Dormois JC, Abraham GN, Lewis K, Dixon K (1976) Effect of furosemide on the renal excretion of digoxin. Clin Pharmacol Ther 20: 395–400

    PubMed  CAS  Google Scholar 

  13. Brown DD, Juhl RP, Warner SL (1978) Decreased bioavailability of digoxin due to hypocho-lesterolemic interventions. Circulation 58: 164–172

    PubMed  CAS  Google Scholar 

  14. Chen TS, Friedmann HS (1980) Alternation of digoxin pharmacokinetics by a single dose of quinidine. JAMA 244: 669–672

    Article  PubMed  CAS  Google Scholar 

  15. Cockroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16: 31–41

    Article  Google Scholar 

  16. Crawford MH, LeWinter MM, O’Rourke RA, Karlines, Ross J (1975) Combined propranolol and digoxin therapy in angina pectoris. Ann Intern Med 83: 449–455

    PubMed  CAS  Google Scholar 

  17. Croxson MS, Ibbertson HK (1975) Serum digoxin in patients with thyroid disease. Br Med J 3: 566–568

    Article  PubMed  CAS  Google Scholar 

  18. Dick HLH, McCawley EL, Fisher WA (1962) Reserpine-digitalis toxicity. Arch Intern Med 109: 503–506

    PubMed  CAS  Google Scholar 

  19. Doering W (1979) Quinidine - digoxin interaction: Pharmacokinetics, underlying mechanism and clinical implications. N Engl. J Med 301: 400–404

    Article  PubMed  CAS  Google Scholar 

  20. Doherty JE, Perkins WH (1966) Digoxin metabolism in hypo-and hyperthyroidism Ann Intern Med 64: 489–507

    CAS  Google Scholar 

  21. Doherty JE, Perkins WH (1969) Digoxin metabolism in hypo-and hyperthyroidism. Ann Intern Med 64: 489–507

    Google Scholar 

  22. Doherty JE, Straub D, Bisset J, Murphy M (1980) Digoxin-quinidine interaction: Increased di-goxin brain concentration. Am J Cardiol 45: 453

    Article  Google Scholar 

  23. Eickenbusch W, Lahrtz H, Seppelt U, Van Zwieten PA (1970) Serum concentration and urinary excretion of 3H-ouabain and 3H-digitoxin in patients suffering from hyperthyroidism or hypo-thyroidism. Klin Wochenschr 48: 270–275

    Article  PubMed  CAS  Google Scholar 

  24. Ejvinsson G (1978) Effect of quinidine on plasma concentrations of digoxin. Br Med J I: 279–280

    Google Scholar 

  25. Erdmann E (1979) Pharmakodynamische Aspekte medikamentöser Wechselwirkungen-Rezep-torbesetzung and pharmakologische Interaktionen. Internist (Berlin) 20: 229–237

    CAS  Google Scholar 

  26. Erdmann E, Schoner W (1974) Ouabain-receptor interaction in (Nat +K+)-ATPase prepara-tions. IV. The molecular structure of different cardioactive steroids and other substances and their affinity to the glycoside receptor. Naunyn Schmiedebergs Arch Pharmacol 283: 335–356

    Article  PubMed  CAS  Google Scholar 

  27. Evered DC, Chapman C (1971) Plasma digoxin concentrations and digoxin toxicity in hospital patients. Br Heart J 33: 540–545

    Article  PubMed  CAS  Google Scholar 

  28. Fisch C, Knoebel SB (1970) Recognition and therapy of digitalis toxicity. Prog Cardiovasc Dis 13: 71–96

    Article  PubMed  CAS  Google Scholar 

  29. Follath F, Roth M (1980) Bedeutung der Serumkonzentrationsbestimmung bei der Diagnose ei-ner Digitalisintoxikation. Cardiology 65: 9–12

    Article  PubMed  Google Scholar 

  30. Frye RL, Braunwald E (1961) Studies on digitalis III. The influence of triiodothyronine on digi-talis requirements. Circulation 23: 376–382

    PubMed  CAS  Google Scholar 

  31. Gault MH, Charles JD, Sugden DL, Kepkay DC (1977) Hydrolysis of digoxin by acid. J Pharm Pharmacol 29: 27–32

    Article  PubMed  CAS  Google Scholar 

  32. Gaultier M, Fournier E, Efthymiou ML, Frejaville JP, Jouanot P, Deutan M (1968) Intoxication digitalique aigue (70 observ.). Soc Med Hop Paris 119: 247–274

    CAS  Google Scholar 

  33. Gilfrich HJ, Meinertz T (1978) Influence of thyroid function on the pharmacokinetics of cardiac glycosides. In: Bodem G, Dengler HJ (eds) Cardiac Berlin Heidelberg New York, pp 159–166

    Google Scholar 

  34. Gillis RA, Prahle DL, Levitt B (1975) Digitalis: A neuroexcitatory drug. Circulation 52: 739–742

    PubMed  CAS  Google Scholar 

  35. Grosse-Brockhoff F, Hergels KJ, Fritsch WP, Grabensee B, Hausamen TU (1973) Serumdigo-xinspiegel und Nierenfunktion. Dtsch Med Wochenschr 98 : 1547–1551

    Google Scholar 

  36. Hager WD, Fenster P, Mayersohn M, Perrier D, Graves P, Marcus FJ, Goldmann S (1979) Di-goxin-quinidine interaction: pharmacokinetic evaluation. N Engl J Med 300: 1238–1241

    Article  PubMed  CAS  Google Scholar 

  37. Hansten PD (1979) Drug interactions, 4th edn. Lea & Febinger, Philadelphia, p 192

    Google Scholar 

  38. Henderson RR, Bessey PQ, Abelmann WH, Stason WB (1971) Serum digoxin levels in a cardiac outpatient population. A prospective clinical study. Circulation [Suppl II] 44: 177

    Google Scholar 

  39. Howard D, Smith CI, Stewart G, Varias M, Tiller DJ, Hensley DJ, Richards JG (1973) A pro-spective survey of the incidence of cardiac intoxications with digitalis in patients being admitted to the hospital and correlation with serum digoxin levels. NZ Med J 3: 279–284

    Article  CAS  Google Scholar 

  40. Hurwitz N, Wade OL (1969) Intensive hospital monitoring of adverse reactions to drugs. Br Med J I: 531–536

    Google Scholar 

  41. Jellilfe RW, Blankenhorn (1966) Effect of phenobarbital on digitoxin metabolism. Clin Res 14: 160

    Google Scholar 

  42. Jorgensen AW, Sorensen OH (1970) Digitalis intoxication: A comparative study on the inci-dence of digitalis intoxication during the periods 1950–52 and 1964–66. Acta Med Scand 188: 179–183

    Article  PubMed  CAS  Google Scholar 

  43. Juhl RP, Summers, RW, Guillory JK, Blaug SM, Cheng FH, Brown DD (1976) Effect of sulpha-salazine on digoxin bioavailability. Clin Pharmacol Ther 20: 387–394

    PubMed  CAS  Google Scholar 

  44. Klein HO, Lang R, DiSegni E, Kaplinsky E (1980) Verapamil digoxin interaction. N Engl J Med 303: 160

    PubMed  CAS  Google Scholar 

  45. Koch-Weser J, Duhme DW, Greenblatt DJ (1974) Influence of serum digoxin concentration measurements on frequency of digitoxicity. Clin Pharmacol Ther 16: 284

    PubMed  CAS  Google Scholar 

  46. Kuhlmann J (1980) Wechselwirkungen bei der Resorption von Arzneimitteln. Med Klin 75: 802–812

    PubMed  CAS  Google Scholar 

  47. Kuhlmann J (1982) Klinisch relevante Wechselwirkungen von Digitalispräparaten. In: Riet-brock N, Kleinfelder, H (Hrsg) Vieweg, Braunschweig S.32–58

    Google Scholar 

  48. Kuhlmann J, Abshagen U, Rietbrock N (1973) Cleavage of glycoside bonds of digoxin and deri-vatives as a function of pH and time. Naunyn Schmiedebergs Arch Pharmacol 276:149–156

    Article  PubMed  CAS  Google Scholar 

  49. Lahiri K, Ertel W (1974) Mechanism of diphenylhydantoin induced decrease in serum digoxin levels. Clin Res 22: 321 A

    Google Scholar 

  50. Larbig D (1975) Herzinsuffizienz: Digitalistherapie. Therapiewoche 25: 48–61

    CAS  Google Scholar 

  51. Lawrence JR, Summer DJ, Kalk WS, Ratcliffe WA, Whiting B, Gray K, Linsay M (1977) Digo-xin kinetics in patients with thyroid dysfunction. Clin Pharmacol Ther 22: 7–13

    PubMed  CAS  Google Scholar 

  52. Leahey EB, Reiffel J, Drusin RE, Heissenbuttel RH, Lovejoy WP, Bigger JT (1978) Interaction between quinidine and digoxin. JAMA 240: 533–534

    Article  PubMed  Google Scholar 

  53. Lely AH, van Enter CHJ (1972) Non cardiac symptoms of digitalis intoxication. Am Heart J 83: 149–152

    Article  PubMed  CAS  Google Scholar 

  54. Leopold G, Pabst J, Ungethüm W (1981) Pharmakokinetik von Digitoxin. In: Kocksiek K, Riet-brock N (Hrsg) Digitalistherapie bei Herzinsuffizienz Urban & Schwarzenberg, München Wien Baltimore S 4–8

    Google Scholar 

  55. Lichey J, Schröder R, Rietbrock N (1977) Aktuelle Plasmadigoxinkonzentration von Patienten bei Krankenhausaufnahme. Dtsch Med Wochenschr 102: 1056–1060

    Article  PubMed  CAS  Google Scholar 

  56. Lindenbaum J, Maulitz RM, Butler VP (1976) Inhibition of digoxin absorption by neomycin. Gastroenterology 71: 399–404

    PubMed  CAS  Google Scholar 

  57. Lown B, Ehrlich L, Lipschultz B, Blake J (1961) Effect of digitalis in patients receiving reser-pine. Circulation 24: 1185–1191

    PubMed  CAS  Google Scholar 

  58. Lydtin H (1975) Interaktion zwischen Herzglykosiden, β-Rezeptorenblockem und anderen Arz-neimitteln. In: Jahrmärker H (Hrsg) Digitalistherapie. Springer Berlin Heidelberg New York S 96–104

    Chapter  Google Scholar 

  59. Manninen V, Apajalahti A, Melin J, Karesoja M (1973) Altered absorption of digoxin in pa-tients given propantheline and metoclopramide. Lancet I: 398–400

    Article  Google Scholar 

  60. Manninen V, Apajalahti A, Simonen H, Reissell P (1973) Effect of propantheline and metoclo-pramide on absorption of digoxin. Lancet I: 1118–1119

    Article  Google Scholar 

  61. Marcus FJ, Peterson A, Salel A, Scully J, Kapadia GG (1966) The metabolism of tritiated digo-xin in renal insufficiency in dogs and man. J Pharmacol Exp Ther 152: 372–382

    PubMed  CAS  Google Scholar 

  62. McAllister RG, Howell SM, Gomer MS, Selby JB (1976) Effect of intravenous furosemide in the renal excretion of digoxin. J Clin Pharmacol 16: 110–117

    PubMed  CAS  Google Scholar 

  63. Neuvonen PJ, Elfring SM, Eloneu E (1978) Reduction of absorption of digoxin, phenytoin and aspirin by activated charcoal in man. Eur J Clin Pharmacol 13: 213–218

    Article  PubMed  CAS  Google Scholar 

  64. Ogilvie RI, Rhedy J (1972) An educational program in digitalis therapy. JAMA 222: 50–55

    Article  PubMed  CAS  Google Scholar 

  65. Peters U, Risser T, (1981) Therapeutische Aspekte bei einer Kombinationstherapie mit Chinidin und Digitalisglykosiden. Dtsch Med Wochenschr 106: 306–308

    Article  Google Scholar 

  66. Peters U, Hengels KJ, Hausamen, TU, Grosse-Brockhoff F (1975) Einfluß von Rifampicin auf den Metabolismus des Digitoxins. Verh Dtsch Ges Inn Med 81: 1675–1676

    PubMed  CAS  Google Scholar 

  67. Peters U, Hausamen TU, Grosse-Brockhoff F (1978) Digitoxin disposition under rifampicin treatment. In: Bodem G, Dengler HJ (eds) Cardiac glycosides. Springer, Berlin Heidelberg New York, pp 401–411

    Chapter  Google Scholar 

  68. Peters U, Risler T, Grabensee B, Falkenstein U, Kroukou J (1980) Interaktion von Chinidin und Digitoxin beim Menschen. Dtsch Med Wochenschr 105: 438–442

    Article  PubMed  CAS  Google Scholar 

  69. Potter MR, Perrot L, Vechinne J, Restoy R (1964) L’ intoxication digitalique massive. Masson, Paris

    Google Scholar 

  70. Rietbrock N, Alken RG (1980) Color vision deficiencies: A common sign of intoxication in chronically digoxin-treated patients. J Cardiovasc Pharmacol 2: 93–99

    Article  PubMed  CAS  Google Scholar 

  71. Rietbrock N, Kuhlmann J (1977) Pharmakokinetische und klinische Aspekte der Glykosidthe-rapie. Med Klin 72: 435–449

    PubMed  CAS  Google Scholar 

  72. Rietbrock N, Wojahn H, Weinmann J, Hasford J, Kuhlmann J (1978) Tödlich verlaufende ß-Methyldigoxin-Intoxikation in suizidaler Absicht. Dtsch Med Wochenschr 103: 1841–1844

    Article  PubMed  CAS  Google Scholar 

  73. Rietbrock N, Oeff F, Martin K, Kuhlmann J (1978) Glykosidkonzentrationen im Plasma und Intoxikationshäufigkeit nach ß-Methyldigoxin und ß-Acetyldigoxin unter standardisierten Be-dingungen. Herz Kreislauf 10/6: 267–273

    Google Scholar 

  74. Risler T, Grabensee B, Grosse-Brockhoff (1975) EKG-Veränderungen und Digoxin-Serumkon-zentration bei Digitalisintoxikation. Dtsch Med Wochenschr 100: 821–825

    CAS  Google Scholar 

  75. Rodensky PL, Wassermann F (1961) Observations on digitalis intoxications. Arch Intern Med 108: 171–188

    PubMed  CAS  Google Scholar 

  76. Rotmensch HH, Graff E, Terdiman R, Aviram A, Ayzenberg O, Laniado S (1978) Furosemide-induced forced diuresis in digoxin intoxication. Arch Intern Med 138: 1495–1497

    Article  PubMed  CAS  Google Scholar 

  77. Schneider J, Ruiz-Torres A (1977) Bedeutung des Körpergewichtes für die Therapie mit Digo-xin und Digoxinderivaten. Dtsch Med Wochenschr 102: 116–118

    Article  PubMed  CAS  Google Scholar 

  78. Schüren KP, Rietbrock N (1977) Klinische Aspekte der Digitalisintoxikation. Intern Prax 17: 581–601

    Google Scholar 

  79. Schüren KP, Calder D, Hüttemann K (1973) Rhythmusstörungen bei chronischem Cor-pulmo-nale. Dtsch med Wochenschr 98: 2111–2114

    Article  PubMed  Google Scholar 

  80. Seller RH, Cangiano J, Kim KE, Mendelssohn S, Brest AN, Swartz C (1970) Digitalis toxicity and hypomagnesiemia. Am Heart J 79: 57–68

    Article  PubMed  CAS  Google Scholar 

  81. Semple P, Tilstone WJ, Lawson DH (1975) Furosemide and urinary digoxin clearance. N Engl J Med 293: 612–613

    Article  Google Scholar 

  82. Shapiro S, Slone D, Lewis GP, Jick H (1969) The epidemiology of digoxin. J Chronic Dis 22: 361–371

    Article  PubMed  CAS  Google Scholar 

  83. Shenfield GM, Thompson J, Horn DB (1977) Plasma and urinary digoxin in thyroid dysfunc-tion. Eur J Clin Pharmacol 12: 437–443

    Article  PubMed  CAS  Google Scholar 

  84. Sherrod TR (1967) Hosp Pract 2: 56

    Google Scholar 

  85. Smith TW, Willerson JT (1971) Suicidal and accidental digoxin ingestion. Circulation 44: 29–36

    PubMed  CAS  Google Scholar 

  86. Solomon HM, Reich S, Spirt N, Abrams WB (1971) Interactions between digitoxin and other drugs in vitro and in vivo. Ann NY Acad Sci 179: 362–369

    Article  PubMed  CAS  Google Scholar 

  87. Steiness E (1974) Renal tubular secretion of digoxin. Circulation 50: 103–107

    PubMed  CAS  Google Scholar 

  88. Storstein L (1981) Digitoxinintoxikation. In: Kochsiek K, Rietbrock N (Hrsg) Digitalistherapie bei Herzinsuffizienz. Urban & Schwarzenberg, München Wien Baltimore, S 112–117

    Google Scholar 

  89. Storstein L, Janssen H (1976) Studies on digitalis. VI. The effect of heparin on serum protein binding of digitoxin and digoxin. Clin Pharmacol Ther 20: 15–23

    PubMed  CAS  Google Scholar 

  90. Storstein O (1977) Hansteen V, Hatle L, Hillestad L, Storstein L (1977) Studies on digitalis XIII. A prospective study of 649 patients on maintenance treatment with digitoxin. Am Heart J 93: 434–443

    Article  Google Scholar 

  91. Szekely P, Wynne NA (1951) The effects of magnesium on cardiac arrhythmias caused by digi-talis. Clin Sci 10: 241–253

    Google Scholar 

  92. Tsutsumi E, Fujiki H, Takeda H, Fukushima H (1979) Effect of furosemide on serum clearance and renal excretion of digoxin. J Clin Pharmacol 19: 200–204

    PubMed  CAS  Google Scholar 

  93. Vöhringer HF, Kuhlmann J, Rietbrock N (1976) Der Einfluß von Antacida auf die Plasmakon-zentration von Digoxin beim Menschen. Dtsch Med Wochenschr 101: 106–108

    Article  PubMed  Google Scholar 

  94. Waldorf S, Andersen JD, Heebell-Nielsen N, Nielsen OG, Moltke E, Sorensen U, Steiness E (1978) Spironolactone induced changes in digoxin kinetics. Clin Pharmacol Ther 24: 162–167

    Google Scholar 

  95. Willerson JT, Thomas W (1974) Massive digoxin ingestion. Clinical experience and principles of management. Clin Med 29–31

    Google Scholar 

  96. Wirth KE (1981) Arzneimittelinteraktionen bei der Anwendung herzwirksamer Glykoside. Med Welt 32: 234–238

    PubMed  CAS  Google Scholar 

  97. Wirth KE, Fröhlich JC, Hollifield JW, Falkner FC, Sweetman BS, Oates JA (1976) Metabolism of digitoxin in man and its modification by spironolactone. EurJ Clin Pharmacol 9: 345–354

    Article  CAS  Google Scholar 

  98. Zilly W, Breimer DD, Richter E (1977) Pharmacokinetic interaction with rifampicin. Clin Phar-macokinet 2: 61–70

    Article  CAS  Google Scholar 

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Rietbrock, N., Woodcock, B.G., Kuhlmann, J. (1983). Nebenwirkungen und Interaktionen mit anderen Pharmaka. In: Erdmann, E. (eds) Therapie mit Herzglykosiden. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69046-4_8

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