Abstract
Dihydroneopterin triphosphate is the first product of pterin synthesis from guanosine triphosphate. It is further metabolized to tetrahydrobiopterin via sepiapterin and dihydrobiopterin (1). The anabolic biopterin derivatives have been found to accumulate in blood cells during hemopoietic cell proliferation in Beagle dogs (2) and especially, to be a marker of increased proliferation during leukemias; in blasts high concentrations of biopterin were found (3) and neopterin has been identified in the medium of alloantigen-induced lymphocytes (4). - Furthermore from blood of patients with malignant diseases a pteridine binding variant of alpha1-acid glycoprotein (AGPM) has been characterized (5). The glycoprotein moiety differs from normal AGP in its secondary structure; the pteridine chromophore is bound by the sialic acid antennae, resulting in a decreased negative charge as compared to normal AGP (6). Blood biopterin and AGPM levels followed during clinical cases (7) also suggest a participation of the pterin system in (hemopoietic) cell proliferation. These observations prompted us to screen the major intermediates of pterin metabolism to determine whether they are not only lymphocyte products but also whether they have an effect on lymphocyte transformation and lymphoblast proliferation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fukushima, K., Eto, I., Mayumi, I., Richter, W., Goodson, S., Shiota, T. in: Pfleiderer, W. (Ed.), Chemistry and Biology of Pteridines. Walter de Gruyter, Berlin 1975
Ziegler, I., Kolb, H.J., Bodenberger, U., Wilmanns, W.: Blut 44 261, (1962)
Ziegler, I., Fink, M., Wilmanns, W.: Blut 44, 231 (1982)
Fuchs, D., Hausen, A., Huber, C., Margreiter, R., Reibnegger, G., Spielberger, M., Wachter, H.: Hoppe Seiler’s Zeitschr. f. Physiol. Chemie 363, 661 (1982)
Ziegler, I., Maier, K., Fink, M.: Cancer Res. 42, 1567 (1982)
Ziegler, I., Armarego, W.L.F., Fink, M. in: Blair J.A. (Ed.). Chemistry and Biology of Pteridines. Walter de Gruyter (in press)
Fink, M., Ziegler, I., Maier, K., Wilmanns, W.: Cancer Res. 42, 1574–1578 (1982)
Gahmberg, C.G., Andersson, L.C.: J.Exp.Med. 148, 507 (1978)
Tietz, A., Linberg, M., Kennedy, E.P.: J.Biol.Chem. 239, 4081 (1964)
Morton, R.A.: Biochemical Spectroscopy. Adam Hilger, London 1975, Vol. 1, pp. 112–115
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ziegler, I., Hamm, U., Berndt, J. (1983). Participation of Pterins and of a Pteridine Binding Variant of Alpha1-Acid Glycoprotein in the Control of Lymphocyte Transformation and of Lymphoblast Proliferation. In: Fischer, G., Wieser, R.J. (eds) Hormonally Defined Media. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69290-1_42
Download citation
DOI: https://doi.org/10.1007/978-3-642-69290-1_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69292-5
Online ISBN: 978-3-642-69290-1
eBook Packages: Springer Book Archive