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Intestinal Permeability Studies in Humans

  • Chapter
Pharmacology of Intestinal Permeation II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 70 / 2))

Abstract

The intestinal mucosa separates the intestinal lumen from the interior milieu of the body. Substrate which enters the body has to pass this barrier. Anatomical and functional factors determine the permeability of the mucosa for the various substrates which may be different in site, extent or species. The permeation through the mucosa is achieved by several mechanisms such as active, facilitated or passive transport, persorption or pinocytosis; substances may also move from the blood to the intestinal lumen following physicochemical laws. Details of the processes pertaining to intestinal permeability are mainly derived from animal experiments and can only partially be applied to humans. However, there are several techniques which permit study of human intestinal permeability. These methods and their results will be discussed in this chapter.

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Authors
  1. K. Ewe
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  2. R. Wanitschke
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  3. M. Staritz
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Editors and Affiliations

  1. Department of Pharmacology, University of Missouri-Columbia School of Medicine, Columbia, MO, 65212, USA

    Tihamér Z. Csáky M.D. (Professor of Pharmacology) (Professor of Pharmacology)

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Ewe, K., Wanitschke, R., Staritz, M. (1984). Intestinal Permeability Studies in Humans. In: Csáky, T.Z. (eds) Pharmacology of Intestinal Permeation II. Handbook of Experimental Pharmacology, vol 70 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69508-7_14

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  • DOI: https://doi.org/10.1007/978-3-642-69508-7_14

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