Abstract
Predilution hemofiltration (HF) was initiated as a test strategy to evaluate the pathophysiologic significance of “middle molecules” for the uremic patient [1, 2]. As such, the system was devised for use in the patient with stable end stage renal failure (ESRF). As originally applied, it was recognized to be at a disadvantage in the removal of low molecular weight solutes (<350 daltons) when compared with hemodialysis (HD). Since then many changes have occurred in how convective mass transport is applied. Postdilution vs predilution [3] as a means of economizing on diluting fluid, hemodiafiltration (HDF)[4,5,6] which combines the best of both diffusion and convection, and continuous low efficiency HF for the treatment of acute renal failure (ARF)[7] are some of the creative applications to which this ultrafiltration methodology has been put. In placing this spectrum of techniques into the special perspective of “the future of hemofiltration” I wish to take a brief backward look in order to have you join me in extrapolating this line of development into the future.
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References
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Henderson, L.W. (1986). The Future of Hemofiltration. In: Henderson, L.W., Quellhorst, E.A., Baldamus, C.A., Lysaght, M.J. (eds) Hemofiltration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69665-7_18
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DOI: https://doi.org/10.1007/978-3-642-69665-7_18
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