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Contribution to the Characterization of Rabies Street Virus Strain NYC

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Rabies in the Tropics

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Summary

A sufficient dose of NYC rabies virus obtained from canine salivary glands killed 100% of experimentally infected cats, approximately 70% of which showed the aggressive form of the disease. Virus titre and cat mortality remained unchanged after seven passages in mouse brains, but the aggressive form of rabies disappeared almost completely.

Strain NYC virus is poorly neutralized by serum antibodies in dogs, cats and cattle. These antibodies can be induced by various strains of vaccine virus.

As virus neutralization is essential for protection against infection, high post-vaccination antibody titres are of great importance for effective prophylaxis.

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References

  1. Atanasiu P (1973) Quantitative assay and potency test of antirabies serum and immunoglobulin in Laboratory Techniques in Rabies, pp 314–318. Kaplan MM, Koprowski H (eds) World Health Organization, Geneva

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Author information

Authors and Affiliations

  1. Eidg. Vakzine-Institut, Postfach, 4025, Basel, Switzerland

    R. Zutter

Authors
  1. U. Kihm
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  2. R. Zutter
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Editor information

Editors and Affiliations

  1. Institute of Medical Virology and Immunology, University of Essen, Medical School, Hufelandstraße 55, 4300, Essen 1, Germany

    Ernst Kuwert

  2. Fondation Mérieux, 17 rue Bourgelat, 69002, Lyon, France

    Charles Mérieux

  3. The Wistar Institute, 36th Street at Spruce, Philadelphia, PA, 19140, USA

    Hilary Koprowski

  4. Veterinary Public Health, Division of Communicable Diseases, World Health Organization, 1211, Geneva, Switzerland

    Konrad Bögel (Chief) (Chief)

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© 1985 Springer-Verlag Berlin, Heidelberg

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Kihm, U., Zutter, R. (1985). Contribution to the Characterization of Rabies Street Virus Strain NYC. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_9

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  • DOI: https://doi.org/10.1007/978-3-642-70060-6_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13826-6

  • Online ISBN: 978-3-642-70060-6

  • eBook Packages: Springer Book Archive

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