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Envelope Properties of Human T-Cell Leukemia Viruses

  • Chapter
Human T-Cell Leukemia Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 115))

Abstract

Like other retroviruses, human T-cell leukemia viruses (HTLV) encode envelop-antigens. The major antigen is an external glycoprotein of approximately 45000 daltons (gp45) linked (presumably by disulfide bonds) to a 21 000 dalton transmembrane protein (p21). These two proteins are cleaved from a glycosylated env precursor protein with a molecular weight at the cell surface varying between 61 000 and 69 000 daltons, according to the host cell line. These env gene products have recently been identified by Lee et al. (1984) and Schneider et al. (1984). Antibodies raised to synthetic peptides representing env gene sequences (Hattori et al. 1983) and to env-β-galactosidase hybrid proteins produced in Escherichia coli (Kiyokawa et al. 1984) precipitate env products synthesized in HTLV-infected cells.

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Author information

Authors and Affiliations

  1. Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London, SW3 6JB, Great Britain

    Robin A. Weiss & Paul Clapham

  2. Microbiological Research Group, National Institute of Hygiene, 1529, Budapest, Pihenö u-1, Hungary

    Karoly Nagy

  3. Virology Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, 104, Japan

    Hiroo Hoshino

Authors
  1. Robin A. Weiss
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  2. Paul Clapham
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  3. Karoly Nagy
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  4. Hiroo Hoshino
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Editor information

Editors and Affiliations

  1. Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue HMR 401, 90033, Los Angeles, CA, USA

    Peter K. Vogt

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© 1985 Springer-Verlag Berlin · Heidelberg

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Weiss, R.A., Clapham, P., Nagy, K., Hoshino, H. (1985). Envelope Properties of Human T-Cell Leukemia Viruses. In: Vogt, P.K. (eds) Human T-Cell Leukemia Virus. Current Topics in Microbiology and Immunology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70113-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-70113-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70115-3

  • Online ISBN: 978-3-642-70113-9

  • eBook Packages: Springer Book Archive

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