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Alloantisera Against Human Class II Antigens: Definition and Methodology

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HLA Class II Antigens

Abstract

Alloantisera have been and still are the major source of reagents for the recognition of antigenic determinants on class II molecules. The importance of these determinants in immunological processes is clearly recognized, but still poorly understood. Class II determinants are also extensively studied by cellular techniques using homozygous typing cells (HTCs) and primed lymphocyte typing (PLT) reagents. Careful comparison between serological and cellular studies has led to a better understanding of the relations between the serologically defined HLA-DR and DQ specificities and the cellularly defined HLA-D specificities. Recently the addition of monoclonal antibodies that can be used in serological, cellular, and especially biochemical assays has added much to the unravelling of the relationships between the class II determinants.

This work was in part supported by the Dutch Foundation for Medical Research (FUNGO), which is subsidized by the Dutch Organization for the Advancement of Pure Research (ZWO) and the J. A. Cohen Institute for Radiopathology and Radiation Protection (IRS)

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Authors
  1. G. M. T. Schreuder
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  2. A. van Leeuwen
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Editors and Affiliations

  1. Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Pilestredet 32, N-0027, Oslo 1, Norway

    Bjarte G. Solheim (Director) (Director)

  2. Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, S-14186, Huddinge, Sweden

    Erna Møller

  3. Dept. of Microbiology and Immunology, New York Medical College, Valhalla, NY, 10595, USA

    Soldano Ferrone

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© 1986 Springer-Verlag Berlin Heidelberg

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Schreuder, G.M.T., van Leeuwen, A. (1986). Alloantisera Against Human Class II Antigens: Definition and Methodology. In: Solheim, B.G., Møller, E., Ferrone, S. (eds) HLA Class II Antigens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70367-6_11

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  • DOI: https://doi.org/10.1007/978-3-642-70367-6_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70369-0

  • Online ISBN: 978-3-642-70367-6

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