Abstract
Continuous arteriovenous hemofiltration (CAVH) has become a well-established alternative to dialysis therapy for acute renal failure (ARF) due to the multiple major advantages related to CAVH as discussed elsewhere in this book. The continued poor patient survival despite better alimentation, cardiovascular stability, and other advantages is an unresolved problem with CAVH. Late unexpected fatal complications despite successful maintenance by CAVH occur frequently at a time when the patient appears to recover from multiple organ failure. This puzzling Observation was shared by all members of an international panel at a symposium on CAVH for ARF at the University of Michigan in March 1984. In search for possible explanations for these late complications this chapter will review potential problems related to large-volume i.v. fluid administration.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Henderson LW, Beans E (1978) Successful production of sterile pyrogen free electrolyte Solution by ultrafiltration. Kidney Int 14: 522–525
Shaldon S, Beau MC, Deschodt G, Flavier JL, Nilsson L, Ramperez P, Mion C (1983) Three years of experience with on-line preparation of sterile pyrogen free infusate for hemofiltration. Int J Artif Organs 6: 25–26
Felts SK, Schaffner W, Melly MA, Koenig MG (1972) Sepsis caused by contaminated intravenous fluids. Ann Intern Med 77: 881–890
Maki DG, Rhame FS, Mackel DC, Bennett JV (1976) Nationwide epidemic of septicemia caused by contaminated intravenous products. I. Epidemiologie and clinical features. Am J Med 60: 471–485
Frei U, Koch KM (1983) Fever and shock during haemofiltration. Contrib Nephrol 36: 107–114
Port FK, Bernick JJ (1983) Pyrogen and endotoxin reactions during hemodialysis. Contrib Nephrol 36: 100–106
Duma RJ, Latta T (1976) What have we done - the hazards of intravenous therapy. N Engl J Med 294: 1178–1180
D’Arcy PF, Woodside W (1973) Drug additives: a potential source of bacterial contamination of infusion fluids. Lancet 2: 96
Kantor RJ, Carson LA, Graham DR, Petersen NJ, Favero MS (1983) Outbreak of pyrogenic reactions at a dialysis center. Am J Med 74: 449–456
von Herrath D, Schaefer K, Hufler M, Pauls A, Koch KM, Göhl H, Ljunggren L, Gardiner P (1983) Complications of hemofiltration. Int J Artif Organs 6: 49–52
Kaehny WD, Hegg AP, Alfrey AC (1977) Gastrointestinal absorption of aluminum from aluminum-coating antacids. N Engl J Med 296: 1389–1390
Kevy S, Jacobson M (1983) Hepatic effects of the leaching of phthalate ester plasticizer and Silicon. Contrib Nephrol 36: 82–89
Neergaard J, Nielsen B, Faubry V, Christensen DH, Nielson OF (1971) Plasticizers in PVC and the occurrence of hepatitis in a haemodialysis unit. Scand J Urol Nephrol 5: 141–145
United States Pharmacopeia, 20th revision (1980) p 863
British Pharmacopeia (1980) Cambridge University Press, Cambridge, p 578
Turco SJ (1981) Hazards associated with parenteral therapy. Am J Therap Clin Nutr 8: 9–50
Blanchard J, Thompson CM, Schwartz JA (1976) Comparison of methods for detection of particulate matter in large-volume parenterals. Am J Hosp Pharm 33: 144–150
Bommer J, Waldherr R, Gastner M, Lemmes R, Ritz E (1981) Iatrogenic multiorgan silicone inclusions in dialysis patients. Klin Wochenschr 59: 1149–1157
Leong ASA, Disney APS, Gove DW (1982) Spallation and migration of silicone from blood-pump tubing in patients on hemodialysis. N Engl J Med 306: 135–136
DeLuca PP, Rapp RP, Bivins B, McKean HE, Griffen WO (1975) Filtration and infusion Phlebitis: a double-blind prospective clinical study. Am J Hosp Pharm 32: 1001–1007
Evans WE, Barker LF, Simone JV (1976) Double-blind evaluation of 5 Jim final filtration to reduce postinfusion phlebitis. Am J Hosp Pharm 33: 1160–1163
Dimmick JE, Bove KE, McAdams AJ, Benzing G III (1975) Fiber embolization–a hazard of cardiac surgery and catheterization. N Engl J Med 292: 685–687
Gesler RM, Garvin PJ, Klamer B, Robinson RU, Thompson CR, Gibson WR, Wheeler FC, Carlson RG (1973) The biological effects of polystyrene latex particles administered intravenously to rats, a collaborative study. Bull Parenter Drug Assoc 27: 101–113
Brommer J, Waldherr R, Ritz E (1983) Silicone storage disease in long-term hemodialysis patients. Contrib Nephrol 36: 115–126
Anonymus (1975) I.V. filtere. Medical Letter 17: 35–36
Port FK, Bernstein IA (1981) Hepatitis risk from hemodialysis pressure monitors. An in vitro investigation. Artif Organs 5: 638–641
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Port, F.K. (1985). Potential Risks of Large-Volume Intravenous Fluid Therapy by Bacteria, Endotoxins, Trace Elements, and Particulate Matter. In: Kramer, P. (eds) Arteriovenous Hemofiltration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70370-6_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-70370-6_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-15317-7
Online ISBN: 978-3-642-70370-6
eBook Packages: Springer Book Archive