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Effects of Cadmium Exposure in Humans

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Cadmium

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 80))

Abstract

Cadmium is an occupational and environmental contaminant which has received a great deal of attention in the last few years. This concern about the potential hazards of cadmium for human health appears justified in view of the biologic properties of this element. An important toxicologic feature of cadmium is its exceptionally long biologic half-life in the human organism (10–30 years). Evolution has not provided humans with a metabolic pathway for the elimination of this metal. Once absorbed, cadmium is efficiently retained in the organism in which it accumulates throughout life. In the newborn, cadmium is nearly absent, but at the age of 50 years, the cadmium body burden may increase up to 20–30 mg and in people occupationally exposed, it may reach values as high as 200–300 mg. Furthermore, cadmium concentrates in vital organs, particularly in the kidneys. Under low levels of exposure, such as occur in the general environment, 30%-50% of the cadmium body burden is found in the kidneys alone.

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Authors
  1. A. Bernard
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  2. R. Lauwerys
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Editors and Affiliations

  1. Department of Environment Health(56), University of Cincinnati, College of Medicine, 3223 Eden Avenue, 45267, Cincinnati, OH, USA

    Ernest C. Foulkes Ph.D.

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Bernard, A., Lauwerys, R. (1986). Effects of Cadmium Exposure in Humans. In: Foulkes, E.C. (eds) Cadmium. Handbook of Experimental Pharmacology, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70856-5_5

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